Antihyperlipidemic activity of chickpea sprouts supplementation in ovariectomy-induced dyslipidemia in rats

Harini, Sagili; Adilaxmamma, K.; Mohan, Emani Madan; Srilatha, Ch.; Raj, Mekapogu Alpha

doi:10.4103/0975-9476.146546

Cited by 17 publications

(8 citation statements)

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“…The dyslipidaemia after menopause is characterized by high levels of TC and LDL-cholesterol, followed by decreased HDL-cholesterol levels, what may accelerate atherosclerotic processes 39 . In the present study, high levels of TC and LDL-cholesterol were observed in the ovariectomized rats, in agreement with a previous report 44 . However, TAG levels were decreased in both OVX and OVX + GbE rats, probably due to estrogen deficiency.…”

Section: Discussionsupporting

confidence: 94%

Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy

Banin

Machado

Andrade

et al. 2021

Sci Rep

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While several pieces of evidence link obesity and mood disorders in menopause, the mechanisms involved are not yet fully understood. We have previously demonstrated that Ginkgo biloba extract (GbE) both attenuated diet-induced obesity of male rats and restored serotonin-induced hypophagia in ovariectomized female rats. The present study aimed at exploring whether GbE treatment ameliorates ovariectomy-related obesity and anxious/depressive-like behaviours. Wistar female rats were either ovariectomized (OVX) or sham-operated (Sham). After 2 months, either 500 mg/kg of GbE or vehicle were administered daily by gavage for 14 days. Anxious/depressive-like behaviours were assessed by the Elevated Plus Maze and the Forced Swim Tests, respectively. Ovariectomy caused high visceral adiposity, hyperleptinemia, and hypercholesterolemia, and increased the anxiety index (p = 0.048 vs. Sham + GbE) while it decreased the latency to immobility (p = 0.004 vs. Sham). GbE treatment in OVX rats improved body composition, adiponectin levels and blood lipid profile. It also reduced the anxiety index (p = 0.004) and increased the latency to immobility (p = 0.003) of OVX rats. Linear regression analysis demonstrated that leptin (p = 0.047) and total cholesterol levels (p = 0.022) were associated with anxious-like behaviours while body adiposity (p = 0.00005) was strongly associated with depressive-like behaviours. The results showed that GbE therapy was effective in attenuating the deleterious effects of ovariectomy on body composition, lipid profile, and anxious/depressive-like behaviours. Further studies are warranted to better understand the therapeutic potential of GbE in menopause.

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Section: Discussionsupporting

confidence: 94%

Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy

Banin

Machado

Andrade

et al. 2021

Sci Rep

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“…Remarkably, the oral administration of the higher dose of chickpea ‘Giza 1’ extract (CA500) significantly restored the levels of serum total cholesterol, LDL, HDL, and triglycerides to the standard group indicating hepatoprotective activity with preservation of cellular integrity and antilipidemic effect. These results complying with previous reports on chickpeas sprout ( Sharma, 1987 ; Harini et al, 2015 ) ( Table 2 ).…”

Section: Resultssupporting

confidence: 94%

Hepatoprotective Effect and Chemical Assessment of a Selected Egyptian Chickpea Cultivar

et al. 2016

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Chickpea (Cicer arietinum) is a legume of the family Fabaceae, subfamily Faboideae. In Egypt, chickpea seeds are usually consumed at raw green and tender stage, or in the form of mature dry seeds. In our previous study, ‘Giza 1’ seeds exhibited stronger antioxidant activity and higher total phenol content than those from other Egyptian cultivars. In order to assess the biological potential of ‘Giza 1’ seeds in vivo, the extraction procedure was reproduced here. The extract was standardized using liquid chromatography coupled to diode array detector and tandem mass spectrometry (MS/MS) to evaluate their hepatoprotective effect on carbon tetrachloride (CCl4)-induced hepatotoxicity in rats and acute toxicity. Administration of the extract to rats in doses up to 2 g/Kg) did not cause any mortalities or observable signs of toxicity. Further, the plant extract showed a strong hepatoprotective activity based on assessing serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase and levels of albumen, globulin, total protein, total cholesterol, high density lipoprotein, triglycerides, and low density lipoprotein. The antioxidative activity was evaluated by assessing hepatic catalase and superoxide dismutase activity as well as reduced glutathione, and malondialdehyde levels. Additionally, anti-inflammatory activity was observed as the extract significantly lowered the hepatic tumor necrosis factor α content. Histopathological examination of liver tissues indicated that the extract-treated animals showed almost normal hepatic architecture with fewer pathological changes. In conclusion, the current results suggest that the chickpea extract possesses an excellent safety profile with very low acute toxicity. Also, it exhibits a significant hepatoprotective effect against CCl4-induced liver injury in rats. This can be attributed, at least partly, to the antioxidant and anti-inflammatory activity of the isoflavones and phenolic acids content of the extract.

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“…Germinated chickpeas have antioxidant, antihypertensive, antihyperlipidemic, antiadipogenic, and antidiabetic properties. 4–6…”

Section: Introductionmentioning

confidence: 99%

Germinated chickpea protein ficin hydrolysate and its peptides inhibited glucose uptake and affected the bitter receptor signaling pathway in vitro

Chandrasekaran,

Gonzalez de Mejia

2023

Food Funct.

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Antihyperlipidemic activity of chickpea sprouts supplementation in ovariectomy-induced dyslipidemia in rats

Cited by 17 publications

References 50 publications

Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy

Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy

Hepatoprotective Effect and Chemical Assessment of a Selected Egyptian Chickpea Cultivar

Germinated chickpea protein ficin hydrolysate and its peptides inhibited glucose uptake and affected the bitter receptor signaling pathway in vitro

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