A Study of Asterococcus Muris (Streptobacillus Moniliformis): I. Morphologic Aspects and Nomenclature

Heilman, Fordyce R.

doi:10.1093/infdis/69.1.32

Cited by 32 publications

(9 citation statements)

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“…The number of organisms necessary to establish this arthritis depends on the manner in which the organisms are grown and consequently, the cellular morphology, as well as the age of the mouse when inoculated. Growth of the organism on dry horse serum-agar results in a morphology characterized by long streptobacillary cells typical of published descriptions, whereas growth in horse serumbroth results in minute coccoidal cells (9,12,20). Apparently, the longer bacillary forms might be more virulent, as reported (20), due to their possible resistance to phagocytosis, thus allowing more opportunity for enlodgement in the endcirculation system associated with the lesion sites.…”

Section: Resultssupporting

confidence: 56%

Host-Parasite Relationships in Experimental Streptobacillus moniliformis Arthritis in Mice

Savage

1972

Infect Immun

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Several variables of host and parasite, relating to the establishment of the chronic Streptobacillus moniliformis -induced arthritis, were studied. Results from these studies indicated (i) that intravenous inoculation of the organism produced a progressive bacteremia and a polyarthritis, whereas subcutaneous inoculation into the top of the back foot produced an intermittent bacteremia and arthritis only in that foot, (ii) that serum-broth-grown cells were more virulent than serum-agar-grown cells, (iii) that young animals were more susceptible to infection than old, and (iv) that the organism apparently had a predilection for joints. It was also determined that the leukocyte and antibody responses of mice to infection were minimal with a slight neutrophilia and a maximum antibody titer of 1:640 detected after infection. Measurements of the effectiveness of antibody and leukocytes in prevention or resolution of infection indicated (i) that the presence of homologous antibody prior to infection prolonged the incubation period for development of the lesion, (ii) that the opsonic index was 1.2 to 1.4, and (iii) that the organism was apparently resistant to destruction by in vitro phagocytosis and actually increased in number in the presence of phagocytes. It was concluded that these represented some of the prime factors contributing to the establishment of the infection and its chronicity.

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Section: Resultssupporting

confidence: 56%

Host-Parasite Relationships in Experimental Streptobacillus moniliformis Arthritis in Mice

Savage

1972

Infect Immun

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“…Among these are direct slide agglutination and complement fixation techniques with human or naturally or experimentally infected animal sera. 15,40,74,[121][122][123][124][125][126][127][128] Compared to modern methods, these tests show a flaw in sensitivity and specificity. Nevertheless, agglutinating antibodies were also used early in taxonomic studies to type S. moniliformis strains.…”

Section: Indirect Techniques For Detection Of Infectionmentioning

confidence: 99%

Approved and novel strategies in diagnostics of rat bite fever and otherStreptobacillusinfections in humans and animals

Eisenberg¹,

Ewers

Rau

et al. 2016

Virulence

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Rat bite fever (RBF), a worldwide occurring and most likely under-diagnosed zoonosis caused by Streptobacillus moniliformis, represents the most prominent disease of Streptobacillus infections. Recently, novel members have been described, from which a reservoir in rats and other animal species and a zoonotic potential can be assumed. Despite regularly published case reports, diagnostics of RBF continues to represent a 'diagnostic dilemma', because the mostly applied 16S rRNA sequence analysis may be uncertain for proper pathogen identification. Virtually nothing is known regarding prevalence in humans and animal reservoirs. For a realistic assessment of the pathogen's spread, epidemiology and virulence traits, future studies should focus on the genomic background of Streptobacillus. Full genome sequence analyses of a representative collection of strains might facilitate to unequivocally identify and type isolates. Prevalence studies using selective enrichment mechanisms may also enable the isolation of novel strains and candidate species of this neglected group of microorganisms.

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“…Agglutinating and complement fixing antibodies have been demonstrated in the sera of naturally and experimentally infected rats (Heilman, 1941(Heilman, & 1951 and mice (Nelson, 1933;van Rooyen, 1936;Savage, 1972Savage, & 1981. We report the development and use of an enzyme-linked immunosorbent assay (ELISA) for the detection of S. monilijormis antibodies in the sera of mice and rats.…”

Section: Streptobacillus Moniliformis;mentioning

confidence: 99%

“…Serological studies in naturally infected rats, measuring agglutinating antibodies, have been performed several decades ago (Heilman, 1941(Heilman, & 1951Nelson, 1933;van Rooyen, 1936), but apparently have never been introduced into the screening of laboratory animal colonies. The suitability of other serological methods which were used in mice, for the monitoring of rodent colonies, remains to be studied.…”

Section: Observations In Naturally Infected Ratsmentioning

confidence: 99%

An enzyme-linked immunosorbent assay (ELISA) for monitoring rodent colonies for Streptobacillus moniliformis antibodies

et al. 1993

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SummaryAn enzyme-linked immunosorbent assay (ELISA) to measure Streptobacillus moniliformis antibodies in mice and rats was developed. Twelve S. moniliformis strains originating from cases of rat-bite fever and Haverhill fever in man and from various rodent species, showed considerable serological relationship.The ELISA appeared specific since antibodies to S. moniliformis were absorbed by autologous and homologous antigen, but not by heterologous bacterial antigens.Acholeplasma laidlaw;; showed partial serological relationship with S. moniliformis.The ELISA was validated using experimental infections in mice and rats. These studies and observations in naturally infected feral rats, confirmed that S. moniliformis is difficult to grow on primary isolation, and that the ELISA for S. moniliformis antibodies revealed more contaminated animals than culture. Keywords: Streptobacillus moniliformis;Serology; ELISA; Mouse; Rat Streptobacillus monilijormis has been associated with rat-bite fever and Haverhill fever in humans, following a bite and contamination of food by rat urine respectively. The rat has been identified as the main reservoir of S. monilijormis and the bacterium is considered a commensal inhabitant of the nasopharynx in this species of animal. S. moni/iformis has been reported to

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A Study of Asterococcus Muris (Streptobacillus Moniliformis): I. Morphologic Aspects and Nomenclature

Cited by 32 publications

References 0 publications

Host-Parasite Relationships in Experimental Streptobacillus moniliformis Arthritis in Mice

Host-Parasite Relationships in Experimental Streptobacillus moniliformis Arthritis in Mice

Approved and novel strategies in diagnostics of rat bite fever and otherStreptobacillusinfections in humans and animals

An enzyme-linked immunosorbent assay (ELISA) for monitoring rodent colonies for Streptobacillus moniliformis antibodies

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