An enzyme-linked immunosorbent assay (ELISA) for monitoring rodent colonies for <i>Streptobacillus moniliformis</i> antibodies

Boot, R.; Bakker, Richard G.; Thuis, H. C. W.; Veenema, J. L.; Hoog, H. De

doi:10.1258/002367793780745516

Cited by 34 publications

(26 citation statements)

References 15 publications

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“…Serologic assays and slide hemagglutination tests, although used historically (12,55,70) and in some animal research (10,91), are currently not available for use with humans. Although these assays are sufficiently sensitive, the increasing demand for rapid, more-sensitive tests likely has detracted from their utility.…”

Section: Other Methodsmentioning

confidence: 99%

“…The first reports were from a 1926 outbreak in Haverhill, MA, and described an illness termed erythema arthriticum epidemicum caused by an organism named Haverhillia multiformis (55,60). This organism was later shown to be identical to S. moniliformis (10). Patients with Haverhill fever develop signs and symptoms identical to those of rat bite fever.…”

Section: Haverhill Fevermentioning

confidence: 99%

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Rat Bite Fever andStreptobacillus moniliformis

2007

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SUMMARY Rat bite fever, caused by Streptobacillus moniliformis, is a systemic illness classically characterized by fever, rigors, and polyarthralgias. If left untreated, it carries a mortality rate of 10%. Unfortunately, its nonspecific initial presentation combined with difficulties in culturing its causative organism produces a significant risk of delay or failure in diagnosis. The increasing popularity of rats and other rodents as pets, together with the risk of invasive or fatal disease, demands increased attention to rat bite fever as a potential diagnosis. The clinical and biological features of rat bite fever and Streptobacillus moniliformis are reviewed, providing some distinguishing features to assist the clinician and microbiologist in diagnosis.

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Section: Other Methodsmentioning

confidence: 99%

Section: Haverhill Fevermentioning

confidence: 99%

Rat Bite Fever andStreptobacillus moniliformis

2007

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“…87 Earlier assumptions of protein-based strain differences between human and murine isolates as well as between Haverhill and rat bite fever strains 87 were not confirmed by other authors. 80,88 On the other hand, especially differences of HF-versus RBF-strains are unlikely because rats represent the source of infection in both cases and disparities could better be explained by different gene expression following oral or parenteral infection 4 or simply by too few HF-strains under study. Additionally, the time between infection and strain isolation from the host following rat exposure is usually too short to facilitate adaptation of strains and expression of a different phenotype.…”

Section: Chemotaxonomic Patternmentioning

confidence: 99%

“…Deep freezing in brain heart infusion (BHI) broth supplemented with 10-20% (w/v) of glycerol can also be advised (own observations). 88 Lyophilization in fetal calf serum with 6% glucose is also a good option for long-term storage in our laboratory. Resuscitation of sub-lethally damaged strains was successfully achieved by centrifuging the previously frozen organism onto a human endothelial cell culture where regular growth could be initiated.…”

Section: Storage Of Bacteriamentioning

confidence: 99%

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Approved and novel strategies in diagnostics of rat bite fever and otherStreptobacillusinfections in humans and animals

Eisenberg¹,

Ewers

Rau

et al. 2016

Virulence

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Rat bite fever (RBF), a worldwide occurring and most likely under-diagnosed zoonosis caused by Streptobacillus moniliformis, represents the most prominent disease of Streptobacillus infections. Recently, novel members have been described, from which a reservoir in rats and other animal species and a zoonotic potential can be assumed. Despite regularly published case reports, diagnostics of RBF continues to represent a 'diagnostic dilemma', because the mostly applied 16S rRNA sequence analysis may be uncertain for proper pathogen identification. Virtually nothing is known regarding prevalence in humans and animal reservoirs. For a realistic assessment of the pathogen's spread, epidemiology and virulence traits, future studies should focus on the genomic background of Streptobacillus. Full genome sequence analyses of a representative collection of strains might facilitate to unequivocally identify and type isolates. Prevalence studies using selective enrichment mechanisms may also enable the isolation of novel strains and candidate species of this neglected group of microorganisms.

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Mouse

Percy¹,

Barthold

2007

Pathology of Laboratory Rodents and Rabbits

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The laboratory mouse is an artificial creation, and there is no true "wildtype" laboratory mouse. Furthermore, there is no such thing as "normal" microflora, since laboratory mice are maintained in microbially pristine environments devoid of pathogens and opportunistic pathogens, as well as other commensal flora/fauna. House mice, from which laboratory mice originated, are represented by several species and subspecies native to the Old World. Laboratory mice are largely derived from domesticated "fancy mice" that arose from many years of trading of mouse variants among fanciers in Europe, Asia, North America, and Australia. The laboratory mouse genome, including its retroelements, is a mosaic derived from different subspecies of the Mus musculus complex, including M.m. domesticus, M.m. musculus, M.m. castaneus, M.m. molossinus (a natural hybrid of M.m. musculus and M.m. castaneus), and M. bactrianus.The genome of M.m. domesticus is the predominant contributor to most strains of mice, but many inbred strains share a common "Eve" with a mitochondrial genome of M.m. musculus origin, and a common "Adam" that contributed their Y chromosome from Asian mice. In addition, there is evidence that other Mus species, outside of the M. musculus complex, may have contributed to the genome of some laboratory mouse strains. The C57BL mouse genome contains a contribution from M. spretus. The 1st inbred mouse (DBA), and other strains with DBA genetic contributions, was partially derived from Japanese waltzing mice with M. bactrianus parentage. Perhaps the only laboratory mouse that is derived from a single species (subspecies), M.m. domesticus, is the "Swiss" mouse, but there is a high likelihood that several Swiss stocks and strains have been genetically corrupted.There are over 450 inbred strains of laboratory mice that have arisen during the last century, and these strains, which were selectively inbred to pan-genomic homozygosity for purposes entirely unrelated to modern research, are the foundation upon which literally thousands of spontaneous mutants and GEMs have been built. Additional inbred strains have been developed from wild mice (M.m. castaneus, M. spretus, etc.). Furthermore, "outbred" mice (mostly Swiss mice) are highly homozygous and nearly inbred. There is no such thing as an outbred laboratory mouse with a fully heterozygous genome representative of wildtype M. musculus, and there is no wild mouse genetic counterpart of the laboratory mouse. When working with mice, the pathologist must also become facile with hybrids,

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An enzyme-linked immunosorbent assay (ELISA) for monitoring rodent colonies for Streptobacillus moniliformis antibodies

Cited by 34 publications

References 15 publications

Rat Bite Fever andStreptobacillus moniliformis

Rat Bite Fever andStreptobacillus moniliformis

Approved and novel strategies in diagnostics of rat bite fever and otherStreptobacillusinfections in humans and animals

Mouse

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