A study of a biodegradable Mg–3Sc–3Y alloy and the effect of self-passivation on the in vitro degradation

Brar, Harpreet S.; Ball, J.; Berglund, Ida S.; Allen, Josephine B.; Manuel, Michele V.

doi:10.1016/j.actbio.2012.08.004

Cited by 63 publications

(25 citation statements)

References 47 publications

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“…8 Therefore, the activity of LDH in the culture medium could reflect the cytotoxicity of materials 35 and LDH test has been widely used in biocompatibility evaluation for magnesium-based biomaterials. 36–40 In this study, at low Mg 2+ concentrations, significantly higher LDH cytotoxicity than that of control was also observed. It was probably because at low Mg 2+ concentrations, SMC proliferation rate was enhanced and there were more cells in the low Mg 2+ concentration-treated group, leading to an increase in spontaneous LDH release.…”

Section: Discussionsupporting

confidence: 61%

Biphasic responses of human vascular smooth muscle cells to magnesium ion

Zhao

Zhu

2015

J Biomedical Materials Res

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Magnesium-based alloys are promising in biodegradable cardiovascular stent applications. The degradation products of magnesium stents may have significant impacts on the surrounding vascular cells. However, knowledge on the interactions between magnesium ion and vascular cells at the molecular and cellular levels is still largely missing. Vascular smooth muscle cell (SMC) plays an important role in the pathogenesis of restenosis and wound healing after stent implantation. This study evaluated the short-term effects of extracellular magnesium ion (Mg2+) on the cellular behaviors of SMCs. Cellular responses to Mg2+ were biphasic and in a concentration-dependent manner. Low concentrations (10 mM) of Mg2+ increased cell viability, cell proliferation rate, cell adhesion, cell spreading, cell migration rate, and actin expression. In contrast, higher concentrations (40–60 mM) of Mg2+ had deleterious effects on cells. Gene expression analysis revealed that Mg2+ altered the expressions of genes mostly related to cell adhesion, cell injury, angiogenesis, inflammation, coagulation, and cell growth. Finding from this study provides some valuable information on SMC responses toward magnesium ions at the cellular and molecular levels, and guidance for future controlled release of magnesium from the stent material.

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Section: Discussionsupporting

confidence: 61%

Biphasic responses of human vascular smooth muscle cells to magnesium ion

Zhao

Zhu

2015

J Biomedical Materials Res

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“…Page 11 attachment and proliferation [69,70]. The co-implanting of Cr and O in Mg has been studied [71].…”

Section: Resorbable Mg-based Alloysmentioning

confidence: 99%

Metals for bone implants. Part 1. Powder metallurgy and implant rendering

et al. 2014

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“…Because of the low PB ratio, magnesium oxide (MgO), which is the oxide layer that naturally forms on Mg, is not protective and has a low stability in aqueous solutions. The findings of Brar et al (2013) confirmed that selective oxidation through alloying Mg with scandium and yttrium is indeed an effective method to control the rate of degradation of Mg alloys. This concept forms the basis of imparting self-passivation to Mg alloys.…”

Section: Introductionmentioning

confidence: 58%

“…Brar, Ball, Berglund, Allen, and Manuel (2013) studied the protective ability of the oxide film formed on an Mg-3Sc-3Y alloy after thermal oxidation at 500 C for various durations, from 0.5 to 25 h. The oxide layer formed on this alloy was mainly composed of scandium oxide than yttrium oxide, with a higher volume fraction of scandium oxide. Because of the low PB ratio, magnesium oxide (MgO), which is the oxide layer that naturally forms on Mg, is not protective and has a low stability in aqueous solutions.…”

Section: Introductionmentioning

confidence: 99%