A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds

Abstract

Uncontrollable bleeding is a major problem in surgical procedures and after major trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues. Here we design a photo-reactive adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based matrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV light irradiation. These repairs can withstand up to 290 mm Hg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60–160 mm Hg). Most importantly, the hydrogel can stop high-pressure bleeding from pig carotid arteries with 4~ 5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes. Treated pigs survived after hemostatic treatments with this hydrogel, which is well-tolerated and appears to offer significant clinical advantage as a traumatic wound sealant.

Biomass‐Derived Multilayer‐Structured Microparticles for Accelerated Hemostasis and Bone Repair

“…More and more biomedical materials have been explored as major supplements to surgical techniques for intractable bleeding conditions. [1][2][3][4] For instance, bone wax, consisting of paraffin and DOI: 10.1002/advs.202002243 esterified fatty acids, is widely used in almost all fields of surgery due to its low cost and ease of use. [5] However, bone wax has been associated with inflammation, granuloma formation, hindered osteogenesis and even bone wax migration.…”

Green preparation of anti-inflammation an injectable 3D porous hydrogel for speeding up deep second-degree scald wound healing

“…Maintaining 3D porous structures in hydrogels is important in wound healing, as dense, the porous material can absorb wound exudates and largely block the escape of red blood cells and platelets, while maintaining a suitably moist environment for effective wound healing. 38,39 Furthermore, the 3D porous network structure facilitates cell adhesion, growth, and proliferation, which is good at accelerated wound healing. The SEM-observed pore size of GSC222 gelatin-alginate hydrogel was microscale, and denser than GSC213 and GSC231 injectable 3D-PH.…”

Tailoring Gelation Mechanisms for Advanced Hydrogel Applications

“…© 2020 Wiley-VCH GmbH Meanwhile, UV light (λ = 360-480 nm) has been used for the in vivo crosslinking of hydrogel sealants, including GelMA composites [193] and methacryloyl-tropoelastin [194] in various animal models.…”