Biomass‐Derived Multilayer‐Structured Microparticles for Accelerated Hemostasis and Bone Repair

Liu, Jiaying; Hu, Yang; Li, Long; Wang, Chao; Wang, Jia; Li, Yang; Chen, Dafu; Ding, Xiaokang; Shen, Chuanan

doi:10.1002/advs.202002243

Cited by 60 publications

(43 citation statements)

References 38 publications

(55 reference statements)

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“…In addition, many studies have demonstrated that multilayer structures can improve the biostability of lipo some formulations and protect the incorporated compounds in their aqueous interior core or within their multilayer mem brane from external destructive conditions such as light, pH, or enzymes, allowing them to be released at designated tar gets. [29][30][31] Therefore, multilayer liposome is an ideal drug delivery carrier for temoporfin. According to previous reports, HSAencapsulated perfluorocarbon (PFC) (HP) not only has a high oxygencarrying capacity but also prevents oxygen leakage.…”

Section: Preparation and Characterization Of C-ml/hpt/omentioning

confidence: 99%

Nanoengineered Neutrophils as a Cellular Sonosensitizer for Visual Sonodynamic Therapy of Malignant Tumors

et al. 2022

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The rapid evolution of cell‐based theranostics has attracted extensive attention due to their unique advantages in biomedical applications. However, the inherent functions of cells alone cannot meet the needs of malignant tumor treatment. Thus endowing original cells with new characteristics to generate multifunctional living cells may hold a tremendous promise. Here, the nanoengineering method is used to combine customized liposomes with neutrophils, generating oxygen‐carrying sonosensitizer cells with acoustic functions, which are called Acouscyte/O2, for the visual diagnosis and treatment of cancer. Specifically, oxygen‐carried perfluorocarbon and temoporfin are encapsulated into cRGD peptide modified multilayer liposomes (C‐ML/HPT/O2), which are then loaded into live neutrophils to obtain Acouscyte/O2. Acouscyte/O2 can not only carry a large amount of oxygen but also exhibits the ability of long circulation, inflammation‐triggered recruitment, and decomposition. Importantly, Acouscyte/O2 can be selectively accumulated in tumors, effectively enhancing tumor oxygen levels, and triggering anticancer sonodynamics in response to ultrasound stimulation, leading to complete obliteration of tumors and efficient extension of the survival time of tumor‐bearing mice with minimal systemic adverse effects. Meanwhile, the tumors can be monitored in real time by temoporfin‐mediated fluorescence imaging and perfluorocarbon (PFC)‐microbubble‐enhanced ultrasound imaging. Therefore, the nanoengineered neutrophils, i.e., Acouscyte/O2, are a new type of multifunctional cellular drug, which provides a new platform for the diagnosis and sonodynamic therapy of solid malignant tumors.

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Section: Preparation and Characterization Of C-ml/hpt/omentioning

confidence: 99%

Nanoengineered Neutrophils as a Cellular Sonosensitizer for Visual Sonodynamic Therapy of Malignant Tumors

et al. 2022

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“…Characterizations. The chemical structure of CMCh was explored using 1 H and 13 C NMR (INOVA-600, Varian). The chemical shift was reported according to the internal reference of tetramethylsilane (TMS).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…Recently, new types of wound dressings including hydrocolloids, sponges, and hydrogels have been developed. − Among these materials, hydrogel wound dressings were capable of forming physical barriers and provided a moist environment at wound sites to promote cell proliferation and skin regeneration . The hydrogels were normally prepared by one or several types of gelation mechanisms including covalent bonds and noncovalent bonds like coordination bonds, hydrogen bonds, ionic bonds, and Schiff bases. − By replacing steady networks with noncovalent dynamic linkages, the hydrogels could repair the broken network and maintain the mechanical properties without any external stimuli when the structure was destroyed, showing an excellent self-healing property .…”

Section: Introductionmentioning

confidence: 99%

Ultrafast Fabrication of Self-Healing and Injectable Carboxymethyl Chitosan Hydrogel Dressing for Wound Healing

Cao

Cheng

et al. 2021

ACS Appl. Mater. Interfaces

152

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Herein, a new type of injectable carboxymethyl chitosan (CMCh) hydrogel wound dressing with self-healing properties is constructed. First, CMCh samples are homogeneously synthesized in alkali/urea aqueous solutions. Subsequently, trivalent metal ions of Fe3+ and Al3+ are introduced to form coordination bonds with CMCh, leading to an ultrafast gelation process. A series of hydrogels can be obtained by altering the concentration of CMCh and the relative content of metal ions. Owing to the dynamic and reversible characteristics of the coordination bonds, the hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability. Moreover, due to the interaction between the amino groups on CMCh and SO4 2–, the hydrogel undergoes phase separation and can be painlessly detached from the skin with little residue. Taking advantage of all these characteristics, the hydrogel is used as a wound dressing and can significantly accelerate skin tissue regeneration and wound closure. This hydrogel has great potential in the application of tissue engineering.

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“…The in vivo liver bleeding rat model was employed for hemostasis assay on the basis of previously published research. 71 Details are listed in Supporting Information.…”

Section: ■ Conclusionmentioning

confidence: 99%

Highly Stretchable Nanocomposite Hydrogels with Outstanding Antifatigue Fracture Based on Robust Noncovalent Interactions for Wound Healing

Zhang

Shen

et al. 2021

Chem. Mater.

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Stable mechanical properties under cyclic mechanical loads are critical for the applications of hydrogels in flexible electronics and tissue engineering. However, most existing tough hydrogels still face obvious notch sensitivity and suffer from fatigue fracture under continuous load. Designing hydrogels with multifunctional properties, such as high stretchability, toughness, and excellent antifatigue fracture, through a facile strategy is on demand. In this work, the nanocomposite hydrogels with comprehensive mechanical properties were prepared by one-pot polymerization of acrylamide (AM), isocyanoethyl methacrylate-glutamine (IEM-Gln), and Laponite XLG nanosheets. Owing to the potent hydrogen bonds formed by urea groups in IEM-Gln and hydrogen-bonding interaction between the polymer chain and nanoclays, the presented nanocomposite hydrogels displayed excellent mechanical properties (tensile strength of 160 kPa, stretchability of 2600%, compressive strength of 2.3 MPa, and toughness of 3300 J/m2). It was noteworthy that the hydrogels exhibited excellent notch insensitivity and fatigue fracture resistance, and even after 50 cycles, there was no measurable crack propagation observed. In addition, the introduction of clay nanosheets into the gelation system endowed the composite hydrogels with outstanding hemostatic activity and tissue adhesiveness. The nanocomposite hydrogels could not only reduce the skin tension of the wound tissue by their high tensile properties but also accelerate hemostasis in the first stage of wound healing, both of which led to the fast healing of skin wound in mice.

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Biomass‐Derived Multilayer‐Structured Microparticles for Accelerated Hemostasis and Bone Repair

Cited by 60 publications

References 38 publications

Nanoengineered Neutrophils as a Cellular Sonosensitizer for Visual Sonodynamic Therapy of Malignant Tumors

Nanoengineered Neutrophils as a Cellular Sonosensitizer for Visual Sonodynamic Therapy of Malignant Tumors

Ultrafast Fabrication of Self-Healing and Injectable Carboxymethyl Chitosan Hydrogel Dressing for Wound Healing

Highly Stretchable Nanocomposite Hydrogels with Outstanding Antifatigue Fracture Based on Robust Noncovalent Interactions for Wound Healing

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