Green preparation of anti-inflammation an injectable 3D porous hydrogel for speeding up deep second-degree scald wound healing

Abstract

The injectable 3D porous hydrogel with a double crosslinked network could be applied as a multifunctional injectable scald wound dressing material for anti-inflammation, necrotic tissue-removal, and wound closure.

Integrated Optical Coherence Tomography and Deep Learning for Evaluating of the Injectable Hydrogel on Skin Wound Healing

“…The double-crosslinked network structure triggered by EB and Schiff base can significantly strengthen the hydrogel. These results demonstrate that EB irradiation cross-linking injectable 3D-PH can form a stable double-cross-linked network structure [31].…”

“…This biomineralization-enhancing strategy provides a new strategy for developing organic and inorganic hybrid multifunctional (c) the crosslinking mechanism of alginate and CMC under EB irradiation. Reprinted with permission from reference [31].…”

“…Specifically, the level of Ki-67 was increased, while the expression of inflammatory factors was decreased. All of these are beneficial to accelerate the healing process of deep second-degree burn wounds in vivo [31].…”

“…Therefore, scar management is also an important part of wound management, and the ideal result is a dressing that minimizes scarring while allowing the wound to heal quickly. Injectable 3D-PH has the ability to accelerate necrotic tissue removal and wound healing [31]. As shown in Figure 5a, the injectable 3D-PH, coloplast wound dressing and blank control were injected into the wounds of second-degree scald.…”

“…The limitations of the histological analysis method are mainly invasive and destructive, the method generates new wounds during the examination, which delays the time of wound healing and is not suitable for patients at high risk of wound infection, thus reducing the accuracy of wound assessment. Therefore, non-invasive monitoring techniques are a safer way to assess and monitor wound healing, which can help clinicians and researchers more objectively determine and assess whether healing is [31,33,37].…”