A Strategic Plan for Diabetes Canada

Syron, Laura; Cheng, Alice; Senior, Peter

doi:10.1016/j.jcjd.2021.10.009

Cited by 4 publications

(3 citation statements)

References 1 publication

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“…For instance, Diabetes Canada and the American Diabetes Association, founded in 1953 and 1939, respectively, were both established to relieve the burden of national and global diabetes and, most importantly, regularly update guidelines for the prevention, diagnosis and treatment of diabetes. 30 Countries that possess higher income and more resources within their health systems are more inclined to exhibit notable advancements in the management of diabetes, hence providing greater benefits to individuals affected by this condition. 31 However, owing to the epidemic of diabetes in regions with a high SDI, few favourable cohort or period effects are observed, indicating that additional initiatives are still required.…”

Section: Discussionmentioning

confidence: 99%

“…In the high SDI region, diabetes management started early and there were more diabetes management initiatives developed and implemented focusing on people with diabetes. For instance, Diabetes Canada and the American Diabetes Association, founded in 1953 and 1939, respectively, were both established to relieve the burden of national and global diabetes and, most importantly, regularly update guidelines for the prevention, diagnosis and treatment of diabetes 30 . Countries that possess higher income and more resources within their health systems are more inclined to exhibit notable advancements in the management of diabetes, hence providing greater benefits to individuals affected by this condition 31 .…”

Section: Discussionmentioning

confidence: 99%

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Global trends in the burden of chronic kidney disease attributable to type 2 diabetes: An age‐period‐cohort analysis

Liu,

Zhang,

Wang

et al. 2023

Diabetes Obesity Metabolism

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AimTo assess temporal trends of chronic kidney disease (CKD) attributable to type 2 diabetes (T2D) globally and in five sociodemographic index (SDI) regions.Materials and MethodsWe extracted the population data and CKD burden attributable to T2D from the Global Burden of Disease Study 2019. We evaluated the trends of disability‐adjusted life years (DALYs), mortality, prevalence and incidence through age‐period‐cohort modelling, and calculated net drifts (overall annual percentage changes), local drifts (annual percentage changes in each age group), longitudinal age curves (fitted longitudinal age‐specific rates), period relative risks (RRs) and cohort RRs.ResultsFrom 1990 to 2019, the global burden of CKD attributable to T2D showed increasing trends in general. The burden of CKD attributable to T2D was highest in the middle SDI region and lowest in the low SDI region. Age effects increased with age, and peaked at the ages of 75‐79 and 80‐84 years for incidence and prevalence, respectively. Period RRs in the burden of CKD attributable to T2D increased, with the high SDI being the most remarkable in DALYs and mortality, and the middle SDI being the most notable in incidence. Cohort RRs showed unfavourable trends in incidence and prevalence among recent cohorts.ConclusionsAfter a lengthy period of multi‐initiative diabetes management, the high‐middle SDI region exhibited improvement. However, unresolved issues and improvement gaps were still remarkable. Future efforts to reduce the burden of CKD attributable to T2D in the population should prioritize addressing the unfavourable patterns identified.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Global trends in the burden of chronic kidney disease attributable to type 2 diabetes: An age‐period‐cohort analysis

Liu,

Zhang,

Wang

et al. 2023

Diabetes Obesity Metabolism

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“…Many agencies (e.g., U.S. National Institutes of Health ( 25 ), the Canadian Diabetes Association ( 26 )) underline the need to understand the links among risk factors before the formation of metabolic diseases with the aim of informing future prevention and research strategies. Whereas the TyG index is a simple new synthetic and feasible biomarker that has been proven to be of better value than previous indexes in reflecting IR and predicting metabolic diseases.…”

Section: Introductionmentioning

confidence: 99%

Triglyceride-Glucose Index Correlate With Telomere Length in Healthy Adults From the National Health and Nutrition Examination Survey

Zhang

Bai

et al. 2022

Front. Endocrinol.

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AimThe present investigation was designed to test the association between leukocyte telomere length (LTL) and two simple markers of insulin resistance, that is, homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride-glucose (TyG) index in U.S. adults without metabolic diseases.MethodsA total of 6489 U.S. adults without diabetes from NHANES 1999–2002 were analyzed. TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. HOMA-Index was calculated as fasting plasma glucose (mmol/L) × fasting serum insulin (mU/mL)/22.5. LTL was obtained using the quantitative polymerase chain reaction method. Multivariate linear regression analysis was assessed to evaluate the association of TyG index HOMA-IR with LTL. We further conducted a generalized additive model (GAM) and a fitted smoothing curve with penalized spline method.ResultsIt was found that the mean LTL was 5796.1 bp in the measured healthy adults. Overall, TyG index was significantly associated with LTL, while HOMA-IR was not. Compared with participants in tertile 1 of the TyG index, the β (95% CI) for those in the second (8.27 to 8.77) and third (≥ 8.77) were -4.31 (95% CI: -48.12~39.49) and -95.98 (95% CI: -145.08~-46.89), respectively. Subjects with TyG index ≥ 8.77 had statistically significant shorter LTL (β = -93.33, 95%CI: -134.33~-52.32), compared with TyG index < 8.77. We further explored a dose-response relation between TyG index by a decile approach [≤ 7.81 (reference), 7.81-8.04, 8.04-8.21, 8.21-8.37, 8.37-8.52, 8.52-8.68, 8.68-8.83, 8.83-9.03, 9.03-9.33, and >9.33] and LTL. Five subgroups (TyG index 7.81-8.04, 8.04-8.21, 8.21-8.37, 8.37-8.52, and 8.52-8.68) did not show significant effect on LTL; while there was a significantly shorter LTL for participants with the TyG index > 8.68, supporting a threshold effect of TyG index on LTL.ConclusionsThe results suggested that higher TyG index (> 8.68) was closely related to shorter LTL and the TyG index was better associated with LTL than HOMA-IR.

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Challenging diabetes stigma starts and ends with all of us

Speight¹,

Holmes‐Truscott²

2023

The Lancet Diabetes & Endocrinology

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A Strategic Plan for Diabetes Canada

Cited by 4 publications

References 1 publication

Global trends in the burden of chronic kidney disease attributable to type 2 diabetes: An age‐period‐cohort analysis

Global trends in the burden of chronic kidney disease attributable to type 2 diabetes: An age‐period‐cohort analysis

Triglyceride-Glucose Index Correlate With Telomere Length in Healthy Adults From the National Health and Nutrition Examination Survey

Challenging diabetes stigma starts and ends with all of us

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