A STIGMASTEROL GLYCOSIDE FROM THE ROOT WOOD OF &lt;i&gt;Melochia Umbellata&lt;/i&gt; (Houtt) Stapf &lt;i&gt;var.&lt;/i&gt; degrabrata K.

Ridhay, Ahmad; Noor, Alfian; Soekamto, Nunuk Hariani; Harlim, Tjodi; Altena, Ian van

doi:10.22146/ijc.21379

Cited by 30 publications

(21 citation statements)

References 9 publications

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“…31 Stigmasterol (3β-hydroxy-24-ethyl-5,22-cholestadiene) (30) is found in numerous roots from trees and grass plants, as well as algae and fungi. 22,77,78 This steroid was firstly reported in 1907 by Windhaus and Hauth, 79 isolated from Calabar beans (Physostigma venenosum) and its absolute configuration was determined in 1963 by Fitches. 80 Stigmasterol's anti-inflammatory potential has been extensively studied, showing significant results in several animal models.…”

Section: Steroidsmentioning

confidence: 96%

Update: Biological and Chemical Aspects of Senna spectabilis

Selegato¹,

Monteiro²,

Vieira³

et al. 2016

J. Braz. Chem. Soc.

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Senna spectabilis (syn Cassia spectabilis) is one of the most important species within the Fabaceae family, natively found in Central and South America, as well as parts of Asia and Africa. Due to the extensive geographical distribution, this fast-growing tree produces a wide variety of bioactive secondary metabolites, being of special interest for chemical and pharmacological studies. Phytochemical investigations have shown that S. spectabilis produces over 40 constituents from different biosynthetic pathways, including piperidine alkaloids, pentacyclic terpenoids and anthraquinones, displaying antiproliferative, antitumoral and antifungal activities. Moreover, studies have also been conducted to identify endophytic and rizhospheric microorganisms associated to S. spectabilis and their chemical composition, enabling further elucidation of cadinane sesquiterpenoids, cytochalasins, depsipeptides and dibenzopirones. This review aims to provide an updated summary of the main features of S. spectabilis, compiling all currently available information on the chemical and pharmacological composition of its parts and its associated microorganisms.

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Section: Steroidsmentioning

confidence: 96%

Update: Biological and Chemical Aspects of Senna spectabilis

Selegato¹,

Monteiro²,

Vieira³

et al. 2016

J. Braz. Chem. Soc.

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“…The known compounds were identified as echinulin (3), [24,25] tardioxopiperazine B (4), [26] arestrictin A (5), [27] neochinulin D (6), [5,8] variecolorin O (7), [24] claudine A (8), [28] uracil (9), [29] thymine (10), [30] adenine (11), [31] blumenol A (12), [32] stigmasterol-3-O-β-D-glucoside (13), [33] mequinol (14), [34] and ferulic acid (15). [35] Apart from echinulin [25] and neochinulin D, [5] these com- pounds are reported for the first time from A. amstelodami.…”

Section: Isolation and Identification Of Compoundsmentioning

confidence: 99%

Melanogenesis Inhibitors from the Endophytic Fungus Aspergillus amstelodami

Elsbaey

Sallam

El-Metwally

et al. 2019

Chemistry & Biodiversity

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Two new compounds, named 3,4‐dimethoxyphenyl α‐d‐ribofuranoside (1) and 3β‐(β‐d‐glucopyranosyloxy)olean‐12‐ene‐23,28,30‐trioic acid (2), together with thirteen known compounds, were isolated from the white beans culture of the marine derived endophytic fungus Aspergillus amstelodami. Structure elucidation of the new compounds was carried out by one‐, two‐dimensional spectroscopy, and high resolution electrospray ionization mass. The antimelanogenic and anti‐allergic activity of the isolated compounds were investigated. Compounds 4, 7, 1, 3, 11, 6 and 9 selectively suppressed melanin production in B16 melanoma cells, using arbutin as a positive control. Their IC50 values were 30.8±5.57, 38.5±6.08, 52.6±6.64, 98.0±1.16, 100.4±3.05, 112.0±0.22 and 144.7±2.35 μm, respectively, while that of arbutin was 151.7±1.27 μm. The tested compounds did not show any significant anti‐allergic activity in RBL‐2H3 cells, as compared to quercetin.

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“…Visenia. These three types of plants (Paliasa) have long been used by communities in South Sulawesi as traditional medicine to treat hepatitis, liver, cholesterol, diabetes, dysentery and hypertension [2]. While the people of Southeast Sulawesi region familiar with this plant with the name Wonolita and used as a drug itching / scabies [3].…”

Section: Introductionmentioning

confidence: 99%

“…Several secondary metabolite compounds which have been isolated from the M. umbellate plant and have useful biological activities such as; The 3-acetyl-12-oleanen-28-oat (1) compound has the highest inhibitory activity against the growth of bacteria B. subtilis and fungal C. Albicans [10]. Stigmasterol compounds (2) are potentially antibacterial, compounds of 9.10-epoxy melochinone which are toxic to Artemia salina, and murine leukemia P-388 cells, and flavonoid compounds group are 6,6'-dimethoxy-4,4'-dihydroxy-3',2'-furano-isoflavan [2]. Furthermore, two new compounds were found on the tissue stem wood of M. umbellate is Walterion C (3) which is highly toxic to A. salina and murine leukemia cells P-388 and Cleomiscosin (4) [11].…”

Section: Introductionmentioning

confidence: 99%

Isolation of Secondary Metabolite Compounds and Antibacterial Activities Tests From Hexane Extract of Stem Bark Melochia umbellate (Houtt) Stapf var. degrabrata K

Usman¹,

Amir²

2018

Proceedings of the 2017 International Conference on Education and Technology (2017 ICEduTech)

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This research aims to determine the content of secondary metabolite compounds and antibacterial activity of stem bark extract Melochia umbellate (Houtt) Stapf var. degrabrata. Samples of M. umbellate stem bark were extracted by meseration using methanol solvent. Separation and purification is done by partitioning, fractionation with chromatography, and recrystallization. Antibacterial activity test of hexane extract and third isolate from bark of M. umbellate was done by agar diffusion method against bacterium Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Phytochemical test results showed that the hexane extract of bark M. umbellate compounds containing alkaloids and triterpenoids. Isolates of compound D is a triterpenoid group compound, while FKa and FKb compounds are steroid group compounds. The hexane extract had the highest antibacterial activity against B. subtilis bacteria with inhibitory zone diameter 12,0 mm. Isolates of compound D have a weak inhibitory effect on all test bacteria. FKa compound isolates had the highest inhibition against B. subtilis and S. aureus bacteria with inhibitory zone diameters of 18,0 mm and 13,0 mm respectively. Whereas FKb compound isolates have the highest inhibitory effect against B. subtilis bacteria with inhibitory zone diameter 12,0 mm. The results of the test show that FKa compound from bark of M. umbellate has the potential to be antibacterial because the compound is able to inhibit bacterial growth with ˃ 14 mm obstacle zone, especially against B. subtilis bacteria.

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A STIGMASTEROL GLYCOSIDE FROM THE ROOT WOOD OF <i>Melochia Umbellata</i> (Houtt) Stapf <i>var.</i> degrabrata K.

Cited by 30 publications

References 9 publications

Update: Biological and Chemical Aspects of Senna spectabilis

Update: Biological and Chemical Aspects of Senna spectabilis

Melanogenesis Inhibitors from the Endophytic Fungus Aspergillus amstelodami

Isolation of Secondary Metabolite Compounds and Antibacterial Activities Tests From Hexane Extract of Stem Bark Melochia umbellate (Houtt) Stapf var. degrabrata K

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