A standardized method of evaluating exercise-induced asthma

Eggleston, Peyton A.; Guerrant, John L.

doi:10.1016/0091-6749(76)90122-6

Cited by 111 publications

(34 citation statements)

References 12 publications

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“…The incline of the treadmill was set at 5-10%, depending on the physical condition of the child. After a 1-min walk at slow pace, the children started running, and the speed of the treadmill was subsequently adjusted to induce a heart rate >90% of the predicted maximum (approximately 210-age 26 ) by the third minute of the test. Having reached the target heart rate, the children were coached to run for another 3 min, unless discomfort due to dyspnea made further running impossible.…”

Section: Exercise Challengementioning

confidence: 99%

Dose-responses over time to inhaled fluticasone propionate treatment of exercise- and methacholine-induced bronchoconstriction in children with asthma

et al. 2000

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Section: Exercise Challengementioning

confidence: 99%

Dose-responses over time to inhaled fluticasone propionate treatment of exercise- and methacholine-induced bronchoconstriction in children with asthma

et al. 2000

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“…Three days after the test, the exercise test was performed at approximately 13:00 h to eliminate the effects of diurnal variation. Exercise challenge testing was performed on an electrically driven treadmill (Q55xt, Series 90; Quinton Instrument Co., Seattle, WA, USA) for 6 min with a fixed workload adjusted to increase the cardiac frequency to 90% of the maximum predicted for the age of the patient [8]. All subjects breathed unconditioned room air (temperature 22-25°C) and were coached to overcome hyperventilation during testing.…”

Section: Protocolmentioning

confidence: 99%

Severity of exercise-induced bronchoconstriction is related to airway eosinophilic inflammation in patients with asthma

Yoshikawa

Shoji²,

Fujii³

et al. 1998

Eur Respir J

124

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Exercise-induced bronchoconstriction (EIB) is widely prevalent in asthmatic patients. Eosinophilic airway inflammation is considered to be a major factor in the pathogenesis of asthma. However, the effects of eosinophilic airway inflammation on EIB have been elucidated insufficiently. To examine the relationship between the severity of EIB and eosinophilic inflammation, sputum induction and exercise challenge were performed in 21 asthmatic patients. Significantly higher percentages of eosinophils and levels of eosinophil cationic protein (ECP) were found in induced sputum in EIB-positive asthmatics (median (range), eosinophils: 23.5 (11.0-61.0)%; ECP: 1,475 (74.8-17,701) ng x mL(-1)) than in EIB-negative asthmatics (eosinophils: 6.0 (1.0-41.5)% (p=0.006); ECP: 270.6 (10.8-7,700) ng x mL(-1) (p=0.049)). There was a significant correlation between the severity of EIB and the sputum eosinophil percentage (r=0.59, p=0.009) and the level of ECP (r=0.47, p=0.037). The area under the curve of the forced expiratory volume in one second for 30 min after exercise correlated with the percentage of eosinophils (r=0.60, p=0.008) and the level of ECP (r=0.45, p=0.04). There was no correlation between airway responsiveness to methacholine on the one hand and EIB, sputum eosinophils or ECP on the other. In conclusion, these results provide evidence that the severity of bronchoconstriction evoked by exercise is more closely related to eosinophilic airway inflammation than airway hyperresponsiveness to methacholine in asthmatic patients.

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“…Exercise challenge testing was performed on an electrically driven treadmill (Q55xt, Series 90; Quinton Instrument Co., Seattle, WA, USA) for 6 minutes with a fixed workload adjusted to increase the cardiac frequency to 90% of the maximum predicted for the age of the patient (14). A single-lead electrocardiogram and pulse oximetry (502-US; CSI, Tokyo, Japan) were monitored continuously.…”

Section: Exercise Challenge Testingmentioning

confidence: 99%

Role of Vascular Endothelial Growth Factor in Pulmonary Endothelial Cell Injury by Exercise Challenge in Asthmatic Patients

et al. 2006

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This study was designed to examine the role of vascular endothelial growth factor (VEGF) in pulmonary endothelial cell injury by exercise in asthmatics. Post-exercise circulating thrombomodulin (TM) levels were significantly increased in asthmatics. Moreover, the increase in TM levels with exercise was significantly correlated with VEGF level in induced sputum from asthmatics (r = 0.80, p = 0.0007). After inhaled steroid therapy, post-exercise TM levels were significantly decreased, but the increase in TM levels with exercise was also correlated with VEGF level (r = 0.60, p = 0.01). Thus, pulmonary endothelial cells stimulated by VEGF in asthmatic airways may be sensitive to exercise challenge.

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A standardized method of evaluating exercise-induced asthma

Cited by 111 publications

References 12 publications

Dose-responses over time to inhaled fluticasone propionate treatment of exercise- and methacholine-induced bronchoconstriction in children with asthma

Dose-responses over time to inhaled fluticasone propionate treatment of exercise- and methacholine-induced bronchoconstriction in children with asthma

Severity of exercise-induced bronchoconstriction is related to airway eosinophilic inflammation in patients with asthma

Role of Vascular Endothelial Growth Factor in Pulmonary Endothelial Cell Injury by Exercise Challenge in Asthmatic Patients

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