Dose-responses over time to inhaled fluticasone propionate treatment of exercise- and methacholine-induced bronchoconstriction in children with asthma

Hofstra, W. B.; Neijens, H. J.; Duiverman, Eric J.; Kouwenberg, J. M.; Mulder, Paul; Kuethe, Maarten C; Sterk, Peter J.

doi:10.1002/(sici)1099-0496(200006)29:6<415::aid-ppul1>3.0.co;2-7

Cited by 106 publications

(83 citation statements)

References 38 publications

(56 reference statements)

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“…This corroborates the findings of other studies with low doses of budesonide or fluticasone propionate in children with mild asthma [1][2][3][4][5]. However, the magnitude of the protective effects in these studies seemed greater than the effects achieved in the present study.…”

Section: Discussionsupporting

confidence: 92%

“…Continuous treatment with inhaled corticosteroids (ICS) also offers good protection against exercise-induced bronchoconstriction [1][2][3][4][5][6][7][8][9]. In contrast to inhaled bronchodilators, ICS do not have to be taken immediately prior to the exercise, and they modify airway hyperresponsiveness.…”

mentioning

confidence: 99%

“…In contrast to inhaled bronchodilators, ICS do not have to be taken immediately prior to the exercise, and they modify airway hyperresponsiveness. The clinically effective dose for exercise-induced asthma may be different from the dose required to control other asthma outcomes [1,5,[9][10][11][12], and the shape of the dose-response curve for exercise-induced bronchoconstriction may also be different from that of other asthma outcomes. Therefore, more information is needed about the dose-response relationships of the protection of various ICS against exercise-induced bronchoconstriction, in order to ensure optimum therapy with ICS against this condition and to establish what doses of ICS are needed to decrease the bronchial responsiveness so that exercise-induced bronchoconstriction can be adequately controlled.…”

mentioning

confidence: 99%

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Treatment of exercise-induced asthma with beclomethasone dipropionate in children with asthma

Petersen

Agertoft²,

Pedersen³

2004

European Respiratory Journal

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A new hydrofluoroalkane-beclomethasone dipropionate (HFA-BDP) aerosol markedly increases drug delivery to the airways. Therefore, even low doses of HFA-BDP should be effective, and the present study assesses this.A randomised, double-blind, crossover study was used to compare the effect of placebo, HFA-BDP 50 mg or 100 mg given q.d. (QVAR TM Autohaler TM ; 3M Pharmaceuticals, St. Paul, MN, USA) on exercise-induced bronchoconstriction and exhaled nitric oxide (eNO). After a 14-day run-in, 25 children (5-14 yrs old) entered three 4-week treatment periods, separated by a 1-week washout. After each period, the fall in forced expiratory volume in one second (FEV1), after an exercise test, and eNO were measured.Significant treatment effects with no carry-over or period effects were seen for both eNO and maximum fall in FEV1 after exercise. Differences were seen between placebo (fall in FEV1=27.9%; eNO=14.4 parts per billion (ppb)) and either dose of HFA-BDP, but not between the two active doses (50 mg: fall in FEV1=20.8%, eNO=9.3 ppb; 100 mg: fall in FEV1=20.9%, eNO=8.9 ppb).In conclusion, low q.d. doses of hydrofluoroalkane-beclomethasone dipropionate reduced exhaled nitric oxide and exercise-induced bronchoconstriction. Further studies are needed to assess whether q.d. administration of beclomethasone dipropionate is as effective as b.i.d. administration. Eur Respir J 2004; 24: 932-937.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Treatment of exercise-induced asthma with beclomethasone dipropionate in children with asthma

Petersen

Agertoft²,

Pedersen³

2004

European Respiratory Journal

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“…27 Inhaled corticosteroid treatment causes a progressive improvement in methacholine BHR over 24 weeks that is greater with high-dose than with moderate-dose inhaled corticosteroid treatment, whereas the maximum inhibition of EIB during inhaled corticosteroid treatment occurs after 3 weeks and is the same for high-and moderate-dose inhaled corticosteroid treatment. 26 The results of this study show that the airway immunopathology associated with asthma with EIB includes greater injury to the airway epithelium, overexpression of CysLTs, relative underproduction of PGE 2 , and greater airway eosinophilia.…”

Section: Discussionmentioning

confidence: 66%

Airway immunopathology of asthma with exercise-induced bronchoconstriction

Hallstrand

Moody

Aitken

et al. 2005

Journal of Allergy and Clinical Immunology

124

100

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“…Indeed treatment with FP for 2 weeks caused a larger shift in responsiveness for NKA than methacholine. Inhaled steroids have previously been shown to have more of an effect on the response to indirect stimuli such as adenosine monophosphate [27,28], hypertonic saline [29] and exercise [30,31], than to direct stimuli such as histamine or methacholine. The present findings demonstrated that this was also the case for the indirect bronchoconstrictor agonist NKA.…”

Section: Discussionmentioning

confidence: 99%

Effect of inhaled fluticasone on bronchial responsiveness to neurokinin A in asthma

Schoor¹,

Joos²,

Pauwels³

2002

European Respiratory Journal

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Neurokinin (NK) A causes airway narrowing in patients with asthma through direct and indirect mechanisms. The effects of the inhaled glucocorticosteroid fluticasone propionate (FP) on the bronchial responsiveness to NKA and methacholine were studied.Patients (n=11) with mild asthma participated in a randomized, double-blind, placebo-controlled crossover trial. FP (500 mg b.i.d) or matched placebo was administered via Diskhaler TM for 14 days. Bronchial challenges were performed on days 1 and 13 (methacholine) and 0 and 14 (NKA) for each treatment period.At the active treatment period, the mean log2 provocative concentration causing a 20% fall in the forced expiratory volume in one second (PC20) ¡ SEM for NKA was -12.72 ¡ 0.63 at the beginning and -9.77 ¡ 0.49 at the end of the period (pv0.0001), while under placebo, it was -12. 16¡0.82 and -12.19¡0.51 respectively (NS). At the active treatment period, the mean log2 PC20 for methacholine was -5.25¡0.40 at the beginning and -4.22¡0.31 at the end of the period (p=0.012), while under placebo, it was -5.47¡0.47 and -5.24¡0.42 respectively (NS). The reduction in response to NKA was significantly larger than that for methacholine.A 2-week course of an inhaled steroid reduces bronchial responsiveness to neurokinin A, an effect more pronounced than the reduction in bronchial responsiveness to methacholine.

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Dose-responses over time to inhaled fluticasone propionate treatment of exercise- and methacholine-induced bronchoconstriction in children with asthma

Cited by 106 publications

References 38 publications

Treatment of exercise-induced asthma with beclomethasone dipropionate in children with asthma

Treatment of exercise-induced asthma with beclomethasone dipropionate in children with asthma

Airway immunopathology of asthma with exercise-induced bronchoconstriction

Effect of inhaled fluticasone on bronchial responsiveness to neurokinin A in asthma

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