Role of Vascular Endothelial Growth Factor in Pulmonary Endothelial Cell Injury by Exercise Challenge in Asthmatic Patients

Kanazawa, Hiroshi; Tochino, Yoshihiro; Ichimaru, Yukitoshi; Kodama, Toyoki; Kyoh, Shigenori; Umeda, Nobuaki

doi:10.1080/02770900600622653

Cited by 8 publications

(8 citation statements)

References 21 publications

(16 reference statements)

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“…Vascular endothelial growth factor A (VEGFA) is a member of VEGF. Several studies demonstrated that VEGFA is related to vascular endothelial cell injury, but the regulation mechanism of VEGFA on the vascular endothelial cell injury in HICH has not been reported.…”

Section: Introductionmentioning

confidence: 99%

LncRNA‐FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR‐126 in mice with hypertensive intracerebral hemorrhage

et al. 2018

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Section: Introductionmentioning

confidence: 99%

LncRNA‐FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR‐126 in mice with hypertensive intracerebral hemorrhage

et al. 2018

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“…It increases microvascular permeability so that plasma proteins can leak into the extravascular space leading to mucosal edema, narrowing of the airway diameter, and profound alterations in the extracellular matrix (6–8). VEGF was reported to mediate endothelial cell injury during asthma exacerbation induced by exercise challenge (9). It is also considered to have a critical role in T‐helper 2 cell inflammation, cytokine production, and physiologic dysregulation in the lung (10).…”

mentioning

confidence: 99%

“…The increased expression of sputum VEGF in asthmatic children reinforces the concept that it might have a pathogenetic role in bronchial asthma and may represent a biomarker of airway inflammation. challenge (9). It is also considered to have a critical role in T-helper 2 cell inflammation, cytokine production, and physiologic dysregulation in the lung (10).…”

mentioning

confidence: 99%

Vascular endothelial growth factor overexpression in induced sputum of children with bronchial asthma

Hossny¹,

El-Awady²,

Bakr

et al. 2009

Pediatric Allergy Immunology

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Vascular endothelial growth factor (VEGF) induces angiogenesis and increases vascular permeability participating in narrowing of the airway lumen that follows lung injury. We sought to investigate the expression of VEGF in induced sputum during and after recovery from acute episodes of bronchial asthma in children. Eighteen asthmatic children with acute attacks of varying severity were subjected to VEGF estimation by an enzymatic immunoassay in induced sputum. They were followed up till complete remission of symptoms and signs and were then retested. VEGF was also estimated in sputum induced from age 34 and sex‐matched healthy children enrolled as a control group. The sputum VEGF levels during acute asthma [median = 71 ng/ml; mean (s.d.) = 114.6 (121.8) ng/ml] were significantly higher than the levels estimated during remission [median = 50 ng/ml; mean (s.d.) = 45.7 (24.2) ng/ml] and both were higher than the corresponding levels of the control group [median = 36 ng/ml; mean (s.d.) = 31.3 (17.2) ng/ml]. VEGF levels during asthmatic episodes correlated positively to the recovery levels (r = 0.6, p = 0.009). The patients’ VEGF expression did not vary with asthma severity, serum total IgE concentration, peripheral blood eosinophil count, or erythrocyte sedimentation rate of patients. Children on corticosteroids inhalation therapy at enrollment had sputum VEGF levels that were comparable to those on other therapies. The increased expression of sputum VEGF in asthmatic children reinforces the concept that it might have a pathogenetic role in bronchial asthma and may represent a biomarker of airway inflammation.

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“…Such factors could have affected our results. Third, VEGF is elevated in exercise-induced asthma (EIA) and plays an important role in the pathogenesis of EIA [15,28,29]. However, we did not perform an exercise challenge test and thus could not provide information regarding EIA.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of serum vascular endothelial growth factor in young male asthma patients

Lee

Min

Lee

et al. 2017

Korean J Intern Med

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Background/AimsVascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. However, little is known about the potential use of serum levels of VEGF as a biomarker for asthma. We investigated the differences in VEGF levels among normal controls, stable asthma patients, and those with exacerbation of acute asthma. All subjects were young males.MethodsWe measured VEGF levels in each patient group, and examined any serial changes in those with acute exacerbation.ResultsVEGF levels were significantly higher in stable asthmatic patients and even more so in acute asthmatic patients, compared to healthy controls. However, there was no correlation between VEGF levels and forced expiratory volume in 1 second in patients with stable asthma. In addition, there were no correlations between VEGF levels and asthma control test scores. In patients with acute exacerbation, VEGF levels significantly increased during the acute period; their levels decreased gradually at 7 and 14 days after treatment.ConclusionsCompared to normal control patients, the serum levels of VEGF were elevated in stable asthma patients and even more elevated in patients with acute exacerbation. However, the role of VEGF as a biomarker in stable asthma is limited. In patients with acute exacerbation, VEGF levels were associated with clinical improvements.

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Role of Vascular Endothelial Growth Factor in Pulmonary Endothelial Cell Injury by Exercise Challenge in Asthmatic Patients

Cited by 8 publications

References 21 publications

LncRNA‐FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR‐126 in mice with hypertensive intracerebral hemorrhage

LncRNA‐FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR‐126 in mice with hypertensive intracerebral hemorrhage

Vascular endothelial growth factor overexpression in induced sputum of children with bronchial asthma

Clinical significance of serum vascular endothelial growth factor in young male asthma patients

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