A Stable Isotope-Mass Spectrometric Method for Measuring Human Spermatogenesis Kinetics In Vivo

Misell, Lisa; Holochwost, Daniel; Boban, Drina; Santi, Nurul Kamilah; Shefi, Shai; Hellerstein, Marc K.; Turek, Paul J.

doi:10.1016/s0022-5347(05)00053-4

Cited by 82 publications

(37 citation statements)

References 13 publications

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“…The duration of spermatogenesis has been recently found to be about 60 days instead of 70 ± 4 days as had previously been described for past many years [4]. Sperm production essentially corresponds to the interactive outcome of biological, physical, and occupational factors, acting within the preceding 2 months from ejaculation.…”

Section: Definitionsmentioning

confidence: 69%

Engaging Practicing Gynecologists in the Management of Infertile Men

Agarwal

Hamada

Esteves³

2014

J Obstet Gynecol India

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In the modern era, contemporary management of male infertility has undergone groundbreaking changes with the introduction of new concepts, advanced testing, and therapeutic interventions. As practicing gynecologists are often the first physicians who encounter an infertile couple, it is essential that these clinicians are continuously updated about the new pearls and pitfalls of male infertility management. Semen analysis is commonly ordered by gynecologists. In 2010, the WHO released new cutoff reference values for the semen parameters adopting novel methodology, which has incited much debate. Reference values have been lowered in comparison with previous standards, with a direct clinical implication in decision-making strategies. Specialized sperm-function tests, such as sperm oxidative stress and sperm chromatin integrity assessments, became clinically available, thus offering an opportunity to better understand sperm dysfunctions concealed during routine semen analysis. Furthermore, the initial counseling of azoospermic men by an andrologically well educated gynecologist may alleviate the misconception and distress surrounding the false belief of sterility, and will clarify the 123 available options of percutaneous and microsurgical spermretrieval techniques and assisted conception outcome. Regarding varicocele, which is commonly seen in infertile males, it is now clear that the best treatment option for infertile men with clinical varicocele is the microsurgical vein ligation. Natural conception is significantly improved after varicocelectomy, and recent data suggest that such treatment optimizes reproductive outcome of couples undergoing ICSI or micro-TESE sperm retrieval. Lastly, new therapeutic interventions, including oral antioxidant therapy and lifestyle modifications, have gained increasing attention, as they aid in alleviating male infertility.

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Section: Definitionsmentioning

confidence: 69%

Engaging Practicing Gynecologists in the Management of Infertile Men

Agarwal

Hamada

Esteves³

2014

J Obstet Gynecol India

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“…So there is a debate and controversy of long -term use of antioxidants. Though, previously it was used for 80-90 days now it is recommended to use the combination for 60 days only [58]. So we used combination of high dose only for 60 days.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Efficacy of Low Dose and High Dose Antioxidants along with Antibiotics in Idiopathic Oligo, Astheno and Oligoasthenospermia

Bm¹,

Ehsan²,

Ehsan³

et al. 2015

Andrology

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Objective: The aim of this study was to explore the efficacy of low dose and high dose antioxidants for the treatment of idiopathic oligiospermia, asthenospermia and oligoasthenospermia. Materials and methods:This prospective quasi experimental study was conducted in Infertility Care and Research Center (ICRC) Ltd, Dhaka, Bangladesh between January 2013 and December 2014. Eighty four patients were the target population for this study. After thorough investigations those patients were diagnosed as idiopathic oligo, astheno and oligoasthenospermia were recruited for this study. Those patients whose female partner had infertility factor except PCOS were excluded from this study. For treatment patients were divided into two groups by lottery. Treatment for group A was Cap Doxycycline 100 mg twice daily for 1 month and tablet Oligocare, low dose antioxidant (Meyer Organic Pvt Ltd, India) 1 tab twice daily for 2 months. Group B was treated by Cap doxycycline 100 mg twice daily for 1 month and combination of micronutrients (High dose antioxidants) for 2 months. Ovulation induction was given to female partner of patient whose semen parameters improved. Results for pregnancy were observed for 6 ovulatory cycles. Data were expressed as mean standard deviation and percentage. Student's t test and χ 2 tests were done for test of significance where appropriate. A p value <0.05 was considered as significant. Results:In both treatment groups both count and motility were increased significantly after 2 months of treatment. Though mean semen parameter improved significantly in both treatment groups, there was significant difference in number of patient improvement between the groups. In high dose group 79% patients improved after two months of treatment whereas 48% patients improved in low dose group. Similarly pregnancy rate was also higher in high dose group 22% in comparison to 12% in low dose group. Conclusion:Antioxidants if can be used at a higher dose instead of low dose can give better result in terms of improvement of sperm count, motility and subsequently pregnancy rates.

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“…Thus, the entire process took about 70 ± 4 days to complete [15]. However, a more recent report suggests that the entire process from production to ejaculation of spermatozoa is completed within a shorter period: an average of 64 ± 8 days (with a range of 42-76 days) [16]. Spermatogenesis begins at puberty and occurs continually throughout the entire male adult life span in contrast to oogenesis, which is finite in women.…”

Section: Spermatogenesismentioning

confidence: 99%

“…The time it takes for Type A spermatogonial to divide is shorter than that required for the entire process of spermatogenesis. The development of Type A spermatogonia into mature spermatids followed by the delivery of mature spermatozoa through the epididymal duct system takes anywhere between 42 and 76 days [16].…”

Section: The Cycle or Wave Of Seminiferous Epitheliummentioning

confidence: 99%