Comparison of Efficacy of Low Dose and High Dose Antioxidants along with Antibiotics in Idiopathic Oligo, Astheno and Oligoasthenospermia

Abstract

Objective: The aim of this study was to explore the efficacy of low dose and high dose antioxidants for the treatment of idiopathic oligiospermia, asthenospermia and oligoasthenospermia. Materials and methods:This prospective quasi experimental study was conducted in Infertility Care and Research Center (ICRC) Ltd, Dhaka, Bangladesh between January 2013 and December 2014. Eighty four patients were the target population for this study. After thorough investigations those patients were diagnosed as idiopathic oligo, astheno and oligoasthenospermia were recruited for this study. Those patients whose female partner had infertility factor except PCOS were excluded from this study. For treatment patients were divided into two groups by lottery. Treatment for group A was Cap Doxycycline 100 mg twice daily for 1 month and tablet Oligocare, low dose antioxidant (Meyer Organic Pvt Ltd, India) 1 tab twice daily for 2 months. Group B was treated by Cap doxycycline 100 mg twice daily for 1 month and combination of micronutrients (High dose antioxidants) for 2 months. Ovulation induction was given to female partner of patient whose semen parameters improved. Results for pregnancy were observed for 6 ovulatory cycles. Data were expressed as mean standard deviation and percentage. Student's t test and χ 2 tests were done for test of significance where appropriate. A p value <0.05 was considered as significant. Results:In both treatment groups both count and motility were increased significantly after 2 months of treatment. Though mean semen parameter improved significantly in both treatment groups, there was significant difference in number of patient improvement between the groups. In high dose group 79% patients improved after two months of treatment whereas 48% patients improved in low dose group. Similarly pregnancy rate was also higher in high dose group 22% in comparison to 12% in low dose group. Conclusion:Antioxidants if can be used at a higher dose instead of low dose can give better result in terms of improvement of sperm count, motility and subsequently pregnancy rates.

Male Subfertility and Efficacy of Fertimax™ Therapy

“…Methylcobalamine (750 mg), Co-Enzyme Q 10 (2.5 mg), Lycopene (2 mg, Folic acid (1.5 mg), L-Arginine (10 mg), L-Carnitine tartarate (50 mg), Iron (5 mg), Zink (7.5 mg), Copper (1 mg), Manganese (2 mg), Selenium (100 mcg), Pyridoxyl hydrochloride (5 mg), Glutathionine (2.5 mg). Results show a significant improvement in sperm count and in total and progressive motility in 79% of patients under Oligocare treatment that based on the use of a mixture of multivitamins and micronutrients as basic antioxidant elements [17].…”

“…In recent years, recourse to the use of micronutrients and vitamins as antioxidants treatment in infertile men has been strongly recommended. So, several reviews of clinical studies addressing the effect of oral antioxidants supplementation (vitamins C, B 12 and E, zinc, selenium, magnesium, arginine folate, carnitine and carotenoids) on sperm quality and pregnancy rate in infertile men have been published recently [14][15][16][17]. It found that a woman was more likely to have a pregnancy or live birth if her male partner took certain vitamins or other antioxidants [18].…”

“…It found that a woman was more likely to have a pregnancy or live birth if her male partner took certain vitamins or other antioxidants [18]. These micronutrients and vitamins can neutralize free radicals, prevent ROS production and DNA fragmentation in spermatozoa, improve outcomes of live birth, pregnancy rates and semen quality among couples undergoing assisted reproduction cycles and stimulate spermatogenesis and androgen synthesis and secretion by several mechanisms [17,19,20].…”