Sperm Biology from Production to Ejaculation

Durairajanayagam, Damayanthi; Rengan, Anil K.; Sharma, Rakesh K.; Agarwal, Ashok

doi:10.1007/978-1-4939-2140-9_5

Cited by 12 publications

(13 citation statements)

References 40 publications

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“…The fertility potential of men is directly related to their semen and/or sperm quality. Physiologically normal spermatogenesis ensures the production of matured sperm that are able to bind and fertilize the ova [62]. Defective spermatogenesis is a common cause of male infertility [63].…”

Section: Discussionmentioning

confidence: 99%

Effect of Antioxidant Supplementation on the Sperm Proteome of Idiopathic Infertile Men

et al. 2019

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Antioxidant supplementation in idiopathic male infertility has a beneficial effect on semen parameters. However, the molecular mechanism behind this effect has not been reported. The objective of this study was to evaluate the sperm proteome of idiopathic infertile men pre- and post-antioxidant supplementation. Idiopathic infertile men were provided with oral antioxidant supplementation once daily for a period of 6 months. Of the 379 differentially expressed proteins (DEPs) between pre- and post-antioxidant treatment patients, the majority of the proteins (n = 274) were overexpressed following antioxidant treatment. Bioinformatic analysis revealed the activation of oxidative phosphorylation pathway and upregulation of key proteins involved in spermatogenesis, sperm maturation, binding of sperm, fertilization and normal reproductive function. In addition, the transcriptional factors associated with antioxidant defense system (PPARGC1A) and free radical scavenging (NFE2L2) were predicted to be functionally activated post-treatment. Key DEPs, namely, NDUFS1, CCT3, PRKARA1 and SPA17 validated by Western blot showed significant overexpression post-treatment. Our novel proteomic findings suggest that antioxidant supplementation in idiopathic infertile men improves sperm function at the molecular level by modulating proteins involved in CREM signaling, mitochondrial function and protein oxidation. Further, activation of TRiC complex helped in nuclear compaction, maintenance of telomere length, flagella function, and expression of zona pellucida receptors for sperm–oocyte interaction.

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Section: Discussionmentioning

confidence: 99%

Effect of Antioxidant Supplementation on the Sperm Proteome of Idiopathic Infertile Men

et al. 2019

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“…Spermatids elongate to form spermatozoa during spermiogenesis and are evacuated from the Sertoli cells to epididymis for final maturation. Spermatozoa in epididymis obtain motility and acrosomal function, which are essential for successful fertilization [ 29 ]. The full cycle for sperm development from production to ejaculation of new mature spermatozoa takes average of 64 days to complete (with a range of 42-76 days) [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Oral Vitamin E on Semen Parameters and IVF Outcome: A Double-Blinded Randomized Placebo-Controlled Clinical Trial

Sabetian

Jahromi

Vakili

et al. 2021

BioMed Research International

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Background. Male infertility is a main clinical problem that affects about 7% of all men worldwide. Many patients with male infertility are caused by a reduced antioxidant capacity of semen. Several antioxidant supplements, especially vitamin E, are proposed to help male infertility treatment. This project was goaled to study the effects of oral synthetic vitamin E (400 IU/day) for eight weeks on betterment of semen parameters and pregnancy rate. Methods. After dropping the cases, 124 infertile couples with a male factor who were admitted to the IVF program were included. The male patients with idiopathic abnormal motility and/or morphology were randomized into two groups: 61 receiving vitamin E and 63 as the control group receiving placebo for eight weeks. The pretreatment semen parameters of both groups were compared with those of posttreatment. The pregnancy outcomes were considered between the two groups. Results. There were no significant differences statistically between before and after treatment in the term of sperm volume, count, motility, and morphology. Furthermore, the IVF outcomes of the two groups were not different significantly, either. Interestingly, the percent of normal sperm in the placebo group was significantly decreased after eight weeks. Conclusion. Vitamin E supplementation might neutralize free radical activity to keep sperm from more oxidative damages. Further studies regarding the influence of higher acceptable doses of vitamin E on semen characteristics and fertility rates are needed. This study was registered as a two-arm, blinded, randomized, placebo-controlled clinical trial (IRCTID: IRCT2014020616506N1, 2014-03-18).

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“…Dengan demikian, seluruh proses memakan waktu sekitar 70 hari. Spermatogenesis dimulai saat pubertas dan terjadi terus menerus sepanjang masa hidup pria dewasa berbeda dengan oogenesis, yang terbatas pada wanita (Durairajanayagam, Rengan, Sharma, & Agarwal, 2015).…”

Section: Hasil Dan Pembahasanunclassified

“…Cairan dari prostat enzim pembekuan yang menyebabkan fibrinogen cairan vesika seminalis membentuk koagulan yang lemah, yang kemudian larut dalam 15-20 menit berikutnya dikarenan lisis oleh fibrinogen yang dibentuk dari profibrinogen prostat. Seorang laki-laki dapatmengeluarkan 300 -400 juta sel spermatozoa pada saat ejakulasi (Durairajanayagam et al, 2015).…”

Section: Hasil Dan Pembahasanunclassified

Ekstrak Pollen Kurma (Phoenix dactylifera L) Sebagai Terapi Infertilitas Pada Pria

Rahmadiani¹

2021

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Pengantar; Infertilitas merupakan salah satu masalah yang dihadapi pasangan yang ingin memiliki keturunan. Infertilitas dalam setahun terjadi sebanyak 15% pada pasangan yang mengharapkan kehamilan. Tujuan; menganalisis bahwa kandungan antioksidan pada DPP dapat menangkal radikal bebas dan mencegah terjadinya stress oksidatif. Metode; analisis dilakukan dengan metode systematic literature review dengan menelaah, mengidentifikasi, mengkaji, dan menyajikannya. Hasil; ditemukan berbagai penelitian yang menunjukkan bahwa ekstrak DPP memiliki efek untuk mencegah dan mengobati kemandulan. Kesimpulan; bahwa adanya penurunan kualitas sperma akibat peningkatan stress oksidatif akibat ketidakseimbangan antioksidan dan radikal bebas

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Sperm Biology from Production to Ejaculation

Cited by 12 publications

References 40 publications

Effect of Antioxidant Supplementation on the Sperm Proteome of Idiopathic Infertile Men

Effect of Antioxidant Supplementation on the Sperm Proteome of Idiopathic Infertile Men

The Effect of Oral Vitamin E on Semen Parameters and IVF Outcome: A Double-Blinded Randomized Placebo-Controlled Clinical Trial

Ekstrak Pollen Kurma (Phoenix dactylifera L) Sebagai Terapi Infertilitas Pada Pria

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