A stability evaluation of a novel titanium dental implant/interconnected porous hydroxyapatite complex under functional loading conditions

Doi, Katsuhiko; Kubo, Takayasu; Kajihara, Shiho; Makihara, Yusuke; Oue, Hiroshi; Oki, Yoshio; Perrotti, Vittoria; Piattelli, Adriano; Akagawa, Yasumasa; Tsuga, Kazuhiro

doi:10.4012/dmj.2016-346

“…Studies confirmed that n-HA can be replaced by newborn bone tissue in a short time and can induce and stimulate the proliferation and differentiation of local osteocytes [ 15 ]. However, a single material cannot well meet the clinical needs, and pure n-HA has high brittleness and low strength [ 16 ]. Therefore, the emergence and development of composite materials provide a new idea for biomedical materials of human tissues.…”

Section: Introductionmentioning

confidence: 99%

Efficiency of Nanohydroxyapatite on Repairing Type II Diabetes Dental Implant-Bone Defect

Ji

¹

,

Lu

²

2022

BioMed Research International

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The purpose of this study was to see how a nanohydroxyapatite (n-HA) composite polyamide 66 (PA66) affected the repair of bone defects in diabetics with titanium implants, as well as to develop experimental materials for the creation of the interface between bone tissue and titanium implants. Rabbit bone marrow mesenchymal stem cells (MSCs) were isolated using n-HA/PA66 composite material, and the effect of coculture with the material on cell proliferation was analyzed after induction of mineralization. Bone defect models of diabetic experimental rabbits and titanium implants were prepared. Normal rabbits with bone defects were used as control (NC group, N = 8 ). After the diabetic bone defect (DM group, N = 8 ) and the implantation of n-HA/PA66 composite material (n-HA/PA66 group, N = 8 ), the differences in body weight, blood glucose, scanning electron microscopy of the implant-bone interface, bone mineral density, new bone trabecular parameters, histomorphology, and biomechanical properties of the implant-bone interface were compared and analyzed. In vitro test results showed that MSC cell growth could be promoted by mineralization induction, the cell growth condition was good after coculture with n-HA/PA66, and the proliferation activity of MSCs was not affected by the material. In vivo test results showed that the body weight of the DM group and n-HA/PA66 group was considerably inferior to that of the NC group, and the blood glucose was dramatically superior to that of the NC group ( P < 0.05 ). However, the body weight of the n-HA/PA66 group was dramatically superior to that of the DM group ( P < 0.05 ). The bone mineral density, bone volume fraction (BV/TV), bone surface area fraction (BS/BV), bone trabecular thickness (Tb.Th), bone trabecular number (Tb.N), bone trabecular area, and biomechanical properties in the DM group were considerably inferior to those in the NC group and n-HA/PA66 group ( P < 0.05 ). The trabecular space (Tb.Sp) in the NC group and n-HA/PA66 group was dramatically superior to that in the NC group ( P < 0.05 ). The bone mineral density, BV/TV, BS/BV, Tb.Th, Tb.N, trabecular area, and biomechanical properties of the n-HA/PA66 group were dramatically superior to those of the NC group ( P < 0.05 ), while Tb.Sp was considerably inferior to that of the NC group ( P < 0.05 ). These findings showed that the n-HA/PA66 material had good biocompatibility and minimal cytotoxicity, and that filling the space between the surrounding bone and the titanium implant can enhance bone repair. This research paved the way for future research into the tissue-engineered bone in the field of oral surgery.

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“…The high concentration of phosphate and calcium should promote migration and maturation of bone tissue cells that conditionate the bone matrix, and it should permit a faster mineralization [ 54 , 55 ]. The processing technique is similar to that of obtaining TPS, with a reduction in the crystallinity of this material (from 5% to 60–70%) [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Endosseous Dental Implant Materials and Clinical Outcomes of Different Alloys: A Systematic Review

Fiorillo

¹

,

Cicciù

²

,

Tözüm

³

et al. 2022

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In recent years, implantology has made significant progress, as it has now become a safe and predictable practice. The development of new geometries, primary and secondary, of new surfaces and alloys, has made this possible. The purpose of this review is to analyze the different alloys present on the market, such as that in zirconia, and evaluate their clinical differences with those most commonly used, such as those in grade IV titanium. The review, conducted on major scientific databases such as Scopus, PubMed, Web of Science and MDPI yielded a startling number of 305 results. After the application of the filters and the evaluation of the results in the review, only 10 Randomized Clinical Trials (RCTs) were included. Multiple outcomes were considered, such as Marginal Bone Level (MBL), Bleeding on Probing (BoP), Survival Rate, Success Rate and parameters related to aesthetic and prosthetic factors. There are currently no statistically significant differences between the use of zirconia implants and titanium implants, neither for fixed prosthetic restorations nor for overdenture restorations. Only the cases reported complain about the rigidity and, therefore, the possibility of fracture of the zirconium. Certainly the continuous improvement in these materials will ensure that they could be used safely while maintaining their high aesthetic performance.

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“…Hydroxyapatite is a substance present in the composition of the mineralized structures of the body; in addition to being autologous, it can artificially reproduce with porous or dense consistency, granular powder and pre-formed blocks. Thus, it forms a chemical bond with the bone (titanium, in fact, exploits a mechanical bond, benefiting from superficial micro-actions) and does not cause local or systemic toxicity and phlegmosis [ 49 , 50 , 51 ].…”

Section: Surface Treatmentsmentioning

confidence: 99%

Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data

Cervino

¹

,

Meto

²

,

Fiorillo

³

et al. 2021

IJERPH

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Recently, interest has grown by focusing on the evaluation of a molecule already produced in the human body such as hyaluronic acid (HA), as an application to the surface of the titanium implant. Its osteo-conductive characteristics and positive interaction with the progenitor cells responsible for bone formation, consequently, make it responsible for secondary stability. The aim of this work was to analyze the various surface treatments in titanium implants, demonstrating that the topography and surface chemistry of biomaterials can correlate with the host response; also focusing on the addition of HA to the implant surface and assessing the biological implications during early stages of recovery. Used as a coating, HA acts on the migration, adhesion, proliferation and differentiation of cell precursors on titanium implants by improving the connection between implant and bone. Furthermore, the improvement of the bioactivity of the implant surfaces through HA could therefore facilitate the positioning of the dental prosthesis precisely in the early loading phase, thus satisfying the patients’ requests. It is important to note that all the findings should be supported by further experimental studies in animals as well as humans to evaluate and confirm the use of HA in any field of dentistry.

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A stability evaluation of a novel titanium dental implant/interconnected porous hydroxyapatite complex under functional loading conditions

Cited by 6 publications

References 24 publications

Efficiency of Nanohydroxyapatite on Repairing Type II Diabetes Dental Implant-Bone Defect

Efficiency of Nanohydroxyapatite on Repairing Type II Diabetes Dental Implant-Bone Defect

Endosseous Dental Implant Materials and Clinical Outcomes of Different Alloys: A Systematic Review

Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data

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