Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data

Abstract

Recently, interest has grown by focusing on the evaluation of a molecule already produced in the human body such as hyaluronic acid (HA), as an application to the surface of the titanium implant. Its osteo-conductive characteristics and positive interaction with the progenitor cells responsible for bone formation, consequently, make it responsible for secondary stability. The aim of this work was to analyze the various surface treatments in titanium implants, demonstrating that the topography and surface chemistry of biomaterials can correlate with the host response; also focusing on the addition of HA to the implant surface and assessing the biological implications during early stages of recovery. Used as a coating, HA acts on the migration, adhesion, proliferation and differentiation of cell precursors on titanium implants by improving the connection between implant and bone. Furthermore, the improvement of the bioactivity of the implant surfaces through HA could therefore facilitate the positioning of the dental prosthesis precisely in the early loading phase, thus satisfying the patients’ requests. It is important to note that all the findings should be supported by further experimental studies in animals as well as humans to evaluate and confirm the use of HA in any field of dentistry.

Free-Floating Aggregate and Single-Cell-Initiated Biofilms of Staphylococcus aureus

“…Furthermore, the biofilm formed from SF-induced aggregates were clearly stained by WGA. This could be explained by a possible ability of S. aureus to bind and incorporate HA in the matrix joint fluids, as explained by other groups [ 33 , 37 ]. The confocal images and COMSTAT analysis further revealed no difference in biofilm formation, when higher and lower bacterial cell concentrations were used to form the aggregates and single cells initiated biofilms.…”

Endosseous Dental Implant Materials and Clinical Outcomes of Different Alloys: A Systematic Review

“…The modification of the surface of the dental implants is performed to influence the responses from the tissues and to be biologically active; the goal of surface modification is to immobilize proteins, enzymes or peptides on the surfaces of the device in order to induce tissue-specific responses [ 68 , 69 , 70 , 71 ].…”

Hyaluronic Acid: A New Approach for the Treatment of Gingival Recession—A Systematic Review

“…It has been found to sustain the cellular proliferation of mesenchymal stromal and pre-osteoblastic cells via regulating the BMP/Smad pathway [ 18 ]. Furthermore, because HA can accelerate tissue healing, it is highly suggested as an adjunctive in periodontal surgeries, papilla regeneration, osseointegration in dental implantation, and peri-implantitis therapies [ 28 , 29 , 30 ].…”