A sportomic follow-up of a muscle injury succeeded by acetaminophen hepatotoxicity

Abstract

IntroductionThe aim of this study is to communicate the diagnosis followed by a successful treatment and rapid evolution from a silent liver injury due to the use of self-medication with large doses of acetaminophen, without a stop in training or a loss of performance. Materials and methodsWe measured the VO 2max and analysed a sportomic pro ile of four national elite cyclists and diagnosed a liver injury caused by pharmaceutical abuse in one athlete. We suggested that the injured athlete decrease both training intensity and volume by 30% to 40% while simultaneously increasing resting and sleeping time. We discontinued the use of acetaminophen and started a high intake of dietary methionine and cysteine together with N-acetyl-cysteine daily. Results After 2 weeks of following our regimen and dietary recommendations, the athlete reported pain relief. This change was corroborated by biochemical analysis, which showed that the amounts of creatine kinase and gammaglutamyltransferase in blood were less than 20% and 70% of pre-treatment levels, respectively. As a referral of our treatment, the team won third place in an 800-km cycling competition. ConclusionThis study has shown that collecting and analysing physiological data during training can give important information about an athlete's clinical condition as well as the degree of performance. In this particular case, we have shown that 2 weeks of reduced training, combined with dietary changes, can promote liver recovery. The importance of this report is that we were able to diagnose and treat a silent liver injury and maintain an athlete's performance during both training and competition.

Investigating the Cellular and Metabolic Responses of World-Class Canoeists Training: A Sportomics Approach

“…As stated by Liebman et al [77], the workflow bench to bedside approach is being refined in the face of a new bedside-bench-bedside approach. Sportomics is useful to evaluate the unprecedented kinetics of some metabolites [3,5,10,11,13,14,16,37,78] and to shed light on the importance of in-field metabolic analyses to the understanding of the inter-individual response to exercise. Besides an effective nutritional support, collecting physiological data during training and competition can provide important information about an athlete’s clinical condition, bringing strategies to modify metabolism during exercise as well as supporting coaches to prescribe their sessions and recovery time.…”

Interleukin 12 correlates with performance, metabolism and acid-base balance during physical exercise

“…The sportomic method aims to generate real competition situations during an experiment, with the objective of understanding the metabolic and immunological alterations, and stress in different organs and systems, as well as selecting the most sensitive biomarkers for each sex, age, training level, type of stress, environmental conditions, and types of exposure [1,6,7,8,9,10].…”