A soft and flexible biosensor using a phospholipid polymer for continuous glucose monitoring

Chu, Ming Xing; Kudo, Hiroyuki; Shirai, Tsuyoshi; Miyajima, Koichiro; Saito, Hirokazu; Morimoto, Nobuo; Yano, Kazuyoshi; Iwasaki, Yasuhiko; Akiyoshi, Kazunari; Mitsubayashi, Kohji

doi:10.1007/s10544-009-9300-1

Cited by 28 publications

(15 citation statements)

References 22 publications

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“…So it is necessary to develop ideal immobilization materials and efficient immobilization method. A series of organic compounds and inorganic materials have been used as enzyme immobilization matrices, such as carbon nanotube [5], magnetic mesoporous silica nanoparticles [6], polymer [7], and carbon-fiber [8,9]. According to previous papers [10][11][12][13], mesoporous silica sieve MCM-41 has been a promising immobilization matrix of enzyme due to its proper pore size, ordered uniform pore structure, proper surface characteristics, and good biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Development of Amperometric Laccase Biosensor through Immobilizing Enzyme in Magnesium‐Containing Mesoporous Silica Sieve (Mg‐MCM‐41)/Polyvinyl Alcohol Matrix

Dai

Guo

Wang

et al. 2014

Journal of Nanomaterials

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Magnesium-containing mesoporous silica sieve (Mg-MCM-41) provided a suitable immobilization of biomolecule matrix due to its uniform pore structure, high surface areas, fast electron-transfer rate, and good biocompatibility. Based on this, an amperometric biosensor was developed by entrapping laccase into the Mg-MCM-41/PVA composite matrix. Laccase from Trametes versicolor was assembled on a composite film of Mg-MCM-41/PVA modified Au electrode and the electrode was investigated by cyclic voltammetry, impedance spectroscopy, and chronoamperometry. The results indicated that the Mg-MCM-41/PVA/Lac modified electrode exhibited excellent catalytic activity towards catechol at room temperature in pH 4.8 acetate buffer solution. The optimum experimental conditions of biosensor for the detection of catechol were studied in detail. Under the optimal conditions, the linear range was from 0.94 to 10.23 μM with the sensitivity of 16.9227 A/M, the detection limit of 0.00531 μM, and the response time of less than 14 s. The Michaelis-Menten constant (KMapp) was estimated by Lineweaver-Burk equation and theKMappvalue was about 1.01 μM. In addition, the biosensor exhibited high reproducibility and long-time stability. This work demonstrated that Mg-MCM-41/PVA composite provides a suitable support for laccase immobilization and construction of biosensor.

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Section: Introductionmentioning

confidence: 99%

Development of Amperometric Laccase Biosensor through Immobilizing Enzyme in Magnesium‐Containing Mesoporous Silica Sieve (Mg‐MCM‐41)/Polyvinyl Alcohol Matrix

Dai

Guo

Wang

et al. 2014

Journal of Nanomaterials

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“…2). (16) The SCL biosensor was designed for the in situ monitoring of the tear sugar level. The most significant feature of the biosensor for tear fluid was that flexible and biocompatible polymers were used for all structural members.…”

Section: Soft Contact Lens (Scl) Biosensor For Tear Glucose Monitoringmentioning

confidence: 99%

Cavitas Biosensors: Noninvasive Approaches to Blood Glucose Monitoring for Diabetes Mellitus

Mitsubayashi¹

2018

Sensors and Materials

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Cavitas sensors that are attached to body cavities, such as the contact lens and mouthguard, have been developed and demonstrated. Being neither implanted nor worn, the cavitas sensors have many advantages for the noninvasive biosensing of chemicals in the permanent body fluid in human body cavities. A soft contact lens (SCL) biosensor for monitoring the sugar content in tears was fabricated using biocompatible polymer and bio-MEMS techniques. It performs realtime monitoring of tear sugar content, which reflects the level of blood glucose. In addition, a wireless mouthguard glucose sensor system for diabetes mellitus has also been developed by incorporating a small potentiostat and a Bluetooth 4.0 low-energy (LE) transmitter to a transparent mouthguard. In the near future, such self-detachable cavitas sensors will allow us to obtain biochemical information, thus improving the quality of life and living standards through daily medicine (health care and presymptomatic and preventive medicine).

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“…As the physiological approach, an ultra‐soft contact lens (CL) biosensor for in situ monitoring of tear glucose was fabricated using Biocompatible PMEH polymer and PDMS . The CL biosensor was designed for in situ monitoring of tear glucose level.…”

Section: Contact Lens Sensors In Conjunctiva Sacmentioning

confidence: 99%

Cavitas Sensors: Contact Lens Type Sensors & Mouthguard Sensors

Mitsubayashi

Arakawa

2016

Electroanalysis

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“Cavitas sensors” attached to body cavities such as the contact lens and mouthguard (“no implantable”, “no wearable”) are attracted attention as self‐detachable devices for daily medicine. Many types of contact lens (CL) sensors using electrical and optical methods have been developed for monitoring not only chemicals (glucose, lactate) and electrical conductivity in tear fluid, but also transcutaneous gases at eyelid mucosa. A CL intraocular pressure telemetric sensor has been also commercialized and applied to patients for monitoring the intraocular pressure. Some mouthguard sensors have been investigated for a real‐time measurement of salivary chemicals. A graphene based sensor on tooth enamel was reported to be capable of salivary bacterium detection. Here we review the challenges regarding the integration of biosensors into monitoring for biological information of body cavities. The self‐detachable cavitas sensors are expected to improve the quality of life in the near future.

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A soft and flexible biosensor using a phospholipid polymer for continuous glucose monitoring

Cited by 28 publications

References 22 publications

Development of Amperometric Laccase Biosensor through Immobilizing Enzyme in Magnesium‐Containing Mesoporous Silica Sieve (Mg‐MCM‐41)/Polyvinyl Alcohol Matrix

Development of Amperometric Laccase Biosensor through Immobilizing Enzyme in Magnesium‐Containing Mesoporous Silica Sieve (Mg‐MCM‐41)/Polyvinyl Alcohol Matrix

Cavitas Biosensors: Noninvasive Approaches to Blood Glucose Monitoring for Diabetes Mellitus

Cavitas Sensors: Contact Lens Type Sensors & Mouthguard Sensors

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