A smartphone based surface plasmon resonance imaging (SPRi) platform for on-site biodetection

Güner, Hasan; Özgür, Erol; Kokturk, Guzin; Çeli̇k, Mehmet; Esen, Elif; Topal, Ahmet E.; Ayas, Sencer; Uludag, Yildiz; Elbüken, Çağlar; Dâna, Aykutlu

doi:10.1016/j.snb.2016.08.061

Cited by 197 publications

(125 citation statements)

References 31 publications

(42 reference statements)

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“…Guner et al described interfacing a smartphone with disposable Blu-ray discs as SPR chips and a 3D printed iSPR attachment [26]. Detection limits were reported as comparable with commercial instruments.…”

Section: Methods For Food Allergen Detection Using a Smartphone Readomentioning

confidence: 99%

“…Connectivity is a key benefit of smartphones as results can instantaneously be uploaded to Cloud databases and results can be disseminated as spatio-temporal maps across the globe [16]. Since their development in 1992 and first use as analytical devices in 2008, smartphones have already been used as sensors, for light microscopy, single-molecule microscopy, cell imaging, bacteria detection, colorimetric detection, enzyme linked immunosorbent assay (ELISA), and lateral flow immunoassays (LFIA), which exemplifies their capabilities as detectors in rapid diagnostics [12, 17–26] . For an in-depth review into all existing smartphone-based diagnostic devices, Quesada-Gonzalez and Merkoçi can be referred to [27].…”

Section: Introductionmentioning

confidence: 99%

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Consumer-friendly food allergen detection: moving towards smartphone-based immunoassays

2018

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In this critical review, we provide a comprehensive overview of immunochemical food allergen assays and detectors in the context of their user-friendliness, through their connection to smartphones. Smartphone-based analysis is centered around citizen science, putting analysis into the hands of the consumer. Food allergies represent a significant worldwide health concern and consumers should be able to analyze their foods, whenever and wherever they are, for allergen presence. Owing to the need for a scientific background, traditional laboratory-based detection methods are generally unsuitable for the consumer. Therefore, it is important to develop simple, safe, and rapid assays that can be linked with smartphones as detectors to improve user accessibility. Smartphones make excellent detection systems because of their cameras, embedded flash functions, portability, connectivity, and affordability. Therefore, this review has summarized traditional laboratory-based methods for food allergen detection such as enzyme-linked-immunosorbent assay, flow cytometry, and surface plasmon resonance, and the potential to modernize these methods by interfacing them with a smartphone readout system, based on the aforementioned smartphone characteristics. This is the first review focusing on smartphone-based food-allergen detection methods designed with the intention of being consumer-friendly. Graphical abstractA smartphone-based food allergen detection system in three easy steps (1) sample preparation, (2) allergen detection on a smartphone using antibodies, which then transmits the data wirelessly, (3) analytical results sent straight to smartphone Electronic supplementary materialThe online version of this article (10.1007/s00216-018-0989-7) contains supplementary material, which is available to authorized users.

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Section: Methods For Food Allergen Detection Using a Smartphone Readomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Consumer-friendly food allergen detection: moving towards smartphone-based immunoassays

2018

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“…The structure of these devices is relatively simple. However, the resolution and dynamic range are often sacrificed [16,17]. To reach a high resolution of 10 −6 RIU or 10 −7 RIU, a spectrometer is always required for an optical-fiber SPR [18].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, some studies have demonstrated the use of 3D printing in SPR platform. Hasan et al developed a smartphone based SPR imaging platform for on-site biodetection [16]. They utilized the 3D printing technique just to print the device holder.…”

Section: Introductionmentioning

confidence: 99%

Angle-Scanning Surface Plasmon Resonance System with 3D Printed Components for Biorecognition Investigation

Zhang

Settu

Liu

2018

Advances in Condensed Matter Physics

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Surface plasmon resonance (SPR) is a real-time, label-free, and high-sensitive detection technology. SPR has been widely used in many applications such as biomolecular interaction analysis, environmental monitoring, and medical diagnostics. However, conventional SPR sensor systems usually require expensive equipment and complicated optics. In this paper, we have demonstrated a rapid prototyping of angle-scanning SPR for bioanalytical investigation. Rapid prototyping was attained by utilizing the FDM (fused deposition modeling) based 3D (three-dimensional) printing technology. Two rotating platforms were employed to drive the laser source and photodiode, respectively. A temperature regulation unit was incorporated to maintain the system temperature in order to reduce the temperature effect. The proposed SPR rapid prototyping yielded a refractive index resolution of 6.4×10 −6 RIU (refractive index unit), and the biotin-avidin system validated the kinetics parameters measurement capability. The obtained results indicated that the FDM 3D printing has great potential for developing rapid-prototyping SPR system.

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“…As depicted in Figure B, Cho et al reported a smartphone‐based fluorescence microscope; the adapter has a 480‐nm bandpass filter, a 500‐nm highpass filter, a microlens, three white LEDs, an objective lens, a 3‐V dual‐battery, a switch, a chip platform, and a plastic body, thus enabling both internal and external in situ monitoring of the organ‐on‐chip. As depicted in Figure C, Guner et al designed a smartphone surface plasmon resonance (SPR) imaging adapter. The adapter consists of an SPR sensor chip, an external lens, a linear polarizer, a beamsplitter plate, a green (520 nm) LED, a multimode fiber optic cable, a collimator, 2 batteries, and a plastic body.…”

Section: Resultsmentioning

confidence: 99%

A review of smartphone point‐of‐care adapter design

Alawsi

Al-Bawi

2019

Engineering Reports

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In this review, we explore the potential of smartphone‐based applications based on their unique ability to support portable, easy‐to‐use, precise, and efficient functions, which, in turn, makes lab‐on‐hardware a trending area of novel research. Smartphones can assist surgeons, physicians, biologists, chemists, ophthalmologists, and laboratory technicians in maintaining an easy‐to‐use, cost‐effective, and integrated environment for treatment, diagnosis, and point‐of‐care (POC) applications. These POC applications can improve patients' quality of life, offering patients a precise diagnosis and the correct treatment. This is a noble goal that aims to reduce costs and to increase the accuracy of sample testing, treatment, and diagnosis. Recent innovations have made major advances in smartphone adapters, providing portability, robustness, self‐powered devices, small‐sized adapters, and ease of usage. Lab‐on‐hardware is a progressing field, and smartphone imaging applications are increasingly expanding, resulting in POC applications with the latest and most advanced image analysis, enhancement, recognition, and other image processing techniques. The most recent studies in the field are explored to provide a solid background to interested researchers against which they can choose of application and/or adapter design they aim to develop, with a discussion of the methods reviewed here.

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A smartphone based surface plasmon resonance imaging (SPRi) platform for on-site biodetection

Cited by 197 publications

References 31 publications

Consumer-friendly food allergen detection: moving towards smartphone-based immunoassays

Consumer-friendly food allergen detection: moving towards smartphone-based immunoassays

Angle-Scanning Surface Plasmon Resonance System with 3D Printed Components for Biorecognition Investigation

A review of smartphone point‐of‐care adapter design

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