A smart microfluidic-based fish farm for zebrafish screening

Mani, Karthick; Chen, Chia Yuan

doi:10.1007/s10404-021-02423-0

Cited by 7 publications

(12 citation statements)

References 38 publications

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“…The larval zebrafish's optical clarity, high fecundity, rapid development, and small size conferred strong advantages in the field of high-throughput chemical screening 27 – 29 . Still, there are still certain drawbacks that need to be taken care of such as the difficulty of high-throughput screening in adult fish as well as inconsistent larval orientation.…”

Section: Introductionmentioning

confidence: 99%

The evaluation of zebrafish cardiovascular and behavioral functions through microfluidics

Subendran

Wang

et al. 2021

Sci Rep

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This study proposed a new experimental approach for the vascular and phenotype evaluation of the non-anesthetized zebrafish with representative imaging orientations for heart, pectoral fin beating, and vasculature views by means of the designed microfluidic device through inducing the optomotor response and hydrodynamic pressure control. In order to provide the visual cues for better positioning of zebrafish, computer-animated moving grids were generated by an in-house control interface which was powered by the larval optomotor response, in conjunction with the pressure suction control. The presented platform provided a comprehensive evaluation of internal circulation and the linked external behaviors of zebrafish in response to the cardiovascular parameter changes. The insights from these imaging sections was extended to identify the linkage between the cardiac parameters and behavioral endpoints. In addition, selected chemicals such as ethanol and caffeine were employed for the treatment of zebrafish. The obtained findings can be applicable for future investigation in behavioral drug screening serving as the forefront in psychopharmacological and cognition research.

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Section: Introductionmentioning

confidence: 99%

The evaluation of zebrafish cardiovascular and behavioral functions through microfluidics

Subendran

Wang

et al. 2021

Sci Rep

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Section: Introductionmentioning

confidence: 99%

“…18 Due to accelerating multifaceted learning and memory paradigms developed for adult zebrafish, 19 researchers have extended their studies on larval zebrafish using tiny wellplates, 20,21 petri dishes, 22 and microfluidic devices. [23][24][25][26][27][28][29] Studies on learning and memory in a laboratory setting require an experimental platform to incorporate the control stimuli. 30 Such stimuli are difficult to manoeuvre in a threedimensional environment of conventional platforms such as plates and dishes.…”

Section: Introductionmentioning

confidence: 99%

Behavioural responses of zebrafish with sound stimuli in microfluidics

Loganathan

Chen

2023

Lab Chip

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“…Among all these, the utilization of a magnetic field for microrobot manipulation has unrivaled advantages, including remote maneuverability 7 , fuel-free propulsion 8 , reconfigurability, programmability 9 and recyclability 10 of magnetic materials, and versatility 11 of combining with other external sources to achieve dual propulsion modes. Therefore, the affinity of different locomotion features activated by the magnetic field brings the substantial possibility to the applications of microrobot in various fields, including biology 12 , bioengineering 13 , medicine 14 , micromanufacturing 15 , and microfluidics 16 – 21 . In biomedical engineering, magnetically driven microrobots were employed for adaptive and multimodal locomotion 22 , carriers for therapeutic and targeted drug delivery 23 , acceleration for t-PA 24 and for stem cell transplantation 25 .…”

Section: Introductionmentioning

confidence: 99%

“…Saadat et al achieved substantial mixing enhancement using the micro-magnetic coils embedded in the microchannel 40 . Apart from this, magnetically activated artificial cilia 16 , 28 , 36 , 41 – 47 have been employed to regulate several hydrodynamic factors of the microfluidic network which results in significant flow manipulation. Though all these techniques appeared to enhance the mixing performance significantly, the strong dependence on the microchannel structure and a frail degree of controllability in flow manipulation alleviate the applicability of such devices to various microfluidic environments.…”

Section: Introductionmentioning

confidence: 99%

An aquatic microrobot for microscale flow manipulation

Subendran

Wang

Loganathan

et al. 2022

Sci Rep

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Microrobots have been developed and extensively employed for performing the variety tasks with various applications. However, the intricate fabrication and actuation processes employed for microrobots further restrict their multitudinous applicability as well as the controllability in high accuracy. As an alternative, in this work an aquatic microrobot was developed using a distinctive concept of the building block technique where the microrobot was built based on the block to block design. An in-house electromagnetic system as well as the control algorithm were developed to achieve the precise real-time dynamics of the microrobot for extensive applications. In addition, pivotal control parameters of the microrobot including the actuating waveforms together with the operational parameters were verified and discussed in conjunction with the magnetic intensity simulation. A mixing task was performed with high efficiency based on the trajectory planning and rotation control of the microrobot to demonstrate its capability in flow manipulation which can be advantageous for microreactor applications down the load. Aside from it, a dissolution test was further conducted to provide an on-demand flow agitation function of the microrobot for the next level of lab chip applications. The presented work with detail dynamic analysis is envisaged to provide a new look of microrobot control and functions from the engineering perspective with profoundly potential applications.

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A smart microfluidic-based fish farm for zebrafish screening

Cited by 7 publications

References 38 publications

The evaluation of zebrafish cardiovascular and behavioral functions through microfluidics

The evaluation of zebrafish cardiovascular and behavioral functions through microfluidics

Behavioural responses of zebrafish with sound stimuli in microfluidics

An aquatic microrobot for microscale flow manipulation

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