A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

Abstract

Herein, we report a unique siRNA-induced peptide co-assembly nanocarrier, which could efficiently co-assemble upon the addition of siRNA, forming nanospheres with high biocompatibility and transfection efficiency both in vitro and in vivo.

Peptide-based nanomaterials: Self-assembly, properties and applications

“…7 Application of Drug delivery (a) Schematic representation of the chemical structure and self-assembled PA nanofibers of a classic peptide amphiphile [ 10 ]. (b) Schematic presentation of the Wpc peptide [ 178 ]. (c) The mechanism of peptide molecular specific recognition, molecular cleavage and in-situ self-assembly [ 181 ].…”

“…7 b.) [ 178 ]. This system is based on peptides modified with methionine, and the peptide-nucleotides nanoparticle is with only nine amino acids.…”

Universal DNA detection realized by peptide based carbon nanotube biosensors

“…39,40 Recently, we have found a peptide (with the sequence Fmoc-RRMEHRMEW) which has a special bio-interaction with tiny nucleic acids and causes a signicant decrease in zeta potential. 41,42 Taking this exciting decrease of zeta potential into consideration, we envisioned that this change of surface potential (which resulted from the interaction between the peptide and nucleic acids) could be greatly amplied and further detected as a sequence-independent DNA biosensor. Based on this, herein, we report a CNT based DNA biosensor with biological molecules as the receptor to achieve the efficient detection and quantication of nucleic acids.…”

AIE Featured Inorganic–Organic Core@Shell Nanoparticles for High-Efficiency siRNA Delivery and Real-Time Monitoring

“…A qualified vehicle for siRNA delivery should significantly enhance its biostability, facilitate the endocytosis, and enrich the siRNA in the target location. To date, numerous vehicles have been developed for siRNA delivery, including lipid/polymer nanoparticles, , amphiphilic dendrimers, DNA carriers, , peptide/protein assemblies, − graphene oxide, mesoporous silica, , gold nanoparticles/nanorods, ,, black phosphorus, etc. However, limitations, including cytotoxicity, serious non-specific absorption, and poor colloidal stability in bio-medium, still accompany these delivery methods.…”