AIE Featured Inorganic–Organic Core@Shell Nanoparticles for High-Efficiency siRNA Delivery and Real-Time Monitoring

He, Xuewen; Yin, Feng; Wang, Dongyuan; Xiong, Ling‐Hong; Kwok, Ryan T. K.; Gao, Peng; Zhao, Zheng; Lam, Jacky W. Y.; Yong, Ken‐Tye; Li, Zigang; Tang, Ben Zhong

doi:10.1021/acs.nanolett.8b04677

Cited by 60 publications

(49 citation statements)

References 50 publications

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“…Till now, the core-shell nanoparticles are achieved by combination of core and shell materials, which have been widely used in the drug delivery due to their superior features, including high specific surface area, nice dispersity, and good chemical (Cheng et al, 2019;He et al, 2019;Yang et al, 2019). The widely used core materials are such as magnetic nanoparticles, metal nanoparticles, silica nanoparticles, etc.…”

Section: Introductionmentioning

confidence: 99%

A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy

Kuang

Zhang

Xiong

et al. 2020

Front. Bioeng. Biotechnol.

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Alzheimer’s disease (AD) is the most common neurodegenerative disease, which seriously affects human health but lacks effective treatment methods. Amyloid β (Aβ) aggregates are considered a possible target for AD treatment. Evidence is increasingly showing that curcumin (CUR) can partly protect cells from Aβ-mediated neurotoxicity by inhibiting Aβ aggregation. However, the efficiency of targeted cellular uptake and bioavailability of CUR is very low due to its poor stability and water-solubility. In order to better improve the cell uptake efficiency and bioavailability of CUR and reduce the cytotoxicity of high-dose CUR, a novel CUR delivery system for AD therapy has been constructed based on the employment of the Fe3O4@carbon dots nanocomposite (Fe3O4@CDs) as the carrier. CUR-Fe3O4@CDs have a strong affinity toward Aβ and effectively inhibit extracellular Aβ fibrillation. In addition, CUR-Fe3O4@CDs can inhibit the production of reactive oxygen species (ROS) mediated by Aβ fibrils and the corresponding neurotoxicity in PC12 cells. More importantly, it can restore nerve damage and maintained neuronal morphology. These results indicate that the application of CUR-Fe3O4@CDs provides a promising platform for the treatment of AD.

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Section: Introductionmentioning

confidence: 99%

A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy

Kuang

Zhang

Xiong

et al. 2020

Front. Bioeng. Biotechnol.

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Section: Monitoring Biological Processesmentioning

confidence: 95%

“…Furthermore, real‐time monitoring is another challenge due to the lack of intrinsic signals of these nucleotide‐based therapies. Benefiting from the numerous advantages of AIEgens compared with conventional organic fluorophores, He et al developed a novel class of nanocarriers for siRNA delivery and real‐time monitoring. In their study, Ag@AIE core@shell NPs were fabricated according to their previous report, in which the NPs were used for multimodality bioimaging .…”

Section: Monitoring Biological Processesmentioning

confidence: 99%

Promising Applications of AIEgens in Animal Models

Situ

Zhao

et al. 2019

Small Methods

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organisms cannot be achieved from these static findings. Therefore, gaining in-depth insights into biological and physiological functions at the in vivo level is of great significance, and various imaging techniques have been explored for this purpose. [1] In addition to the clinically available magnetic resonance imaging (MRI), ultrasonic imaging, computed tomography (CT), positron emission tomography (PET), and single-photon emission computed tomography, fluorescence imaging (another distinct type of optical imaging [1c] from bioluminescence imaging [2] ) has attracted increasing attention, owing to its advantages of high temporal-spatial resolution and sensitivity, noninvasive, and real-time applications, and the ability to provide dynamic information for basic research and (pre-)clinical settings at cellular and subcellular levels. [3] Fluorescent probes or contrast agents are essential for fluorescence imaging. Compared with fluorescent proteins, [4] inorganic nanoparticles (NPs), [5] such as quantum dots, [6] upconversion NPs, [7] and metallic NPs, [8] and organic dyes [9] (e.g., U.S. Food and Drug Administration (FDA)-approved 5-ALA, indocyanine green (ICG), and methylene blue), organic NPs [10] have obvious advantages, such as easy preparation and good biocompatibility. However, many organic NPs show weak fluorescence because they are made with conventional organic dyes, which suffer from the aggregation-caused quenching (ACQ) effect, i.e., their fluorescence is partially or completely quenched in the aggregated state.The advent of the aggregation-induced emission (AIE) concept offers a new strategy to deal with ACQ. [11] AIE refers to the interesting photophysical phenomenon that luminogens are weakly fluorescent or nonfluorescent in solution but show greatly enhanced emission in the aggregated state, primarily because of restricted intramolecular motion. [12] The past 19 years have witnessed spectacular advances of AIEgens, [13] due to their advantages of structural variety, easy functionalization, strong luminescence, large Stokes shift, high photobleaching-resistance, and so on. In particular, various AIE bioprobes have been designed: [14] (i) water-soluble AIEgens, which are comprised of a hydrophobic AIE core and hydrophilic units (e.g., ionic groups, peptides, carbohydrates, DNA, aptamers, antibodies, and poly(ethylene glycol) (PEG)); (ii) bare AIEgen dots (nanoaggregates); iii) AIEgen/biopolymer dots, which can be obtained by loading AIEgens onto biopolymer matrixes covalently (e.g., chitosan, dextran, and starch) or noncovalently (e.g., bovine serum albumin, human serum albumin (HSA), and fetal bovine serum (FBS)); (iv)In vivo investigations using small animal models are of great significance for the comprehensive understanding of biological and physiological functions-seeing is believing. Fluorescence imaging can provide real-time and dynamic information of living systems. During the past few years, aggregation-induced emission luminogens (AIEgens) are widely and rapidly developed for biolog...

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“…AIE aggregates exhibit large Stokes' shift, robust luminosity, strong photobleaching resistance, no random blinking and excellent biocompatibility. Accompanying with the foundation of varying aggregating mechanisms ( Figure 1 , below)43, they have been widely applied for in vitro and in vivo biosensing and imaging44-58. Among them, various systems are synergistically integrated into specific and sensitive detection and differentiation of various pathogens59.…”

Section: Introductionmentioning

confidence: 99%

AIE-based theranostic systems for detection and killing of pathogens

He¹,

Xiong²,

Zhao³

et al. 2019

Theranostics

Self Cite

126

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Pathogenic bacteria, fungi and viruses pose serious threats to the human health under appropriate conditions. There are many rapid and sensitive approaches have been developed for identification and quantification of specific pathogens, but many challenges still exist. Culture/colony counting and polymerase chain reaction are the classical methods used for pathogen detection, but their operations are time-consuming and laborious. On the other hand, the emergence and rapid spread of multidrug-resistant pathogens is another global threat. It is thus of utmost urgency to develop new therapeutic agents or strategies. Luminogens with aggregation-induced emission (AIEgens) and their derived supramolecular systems with unique optical properties have been developed as fluorescent probes for turn-on sensing of pathogens with high sensitivity and specificity. In addition, AIE-based supramolecular nanostructures exhibit excellent photodynamic inactivation (PDI) activity in aggregate, offering great potential for not only light-up diagnosis of pathogen, but also image-guided PDI therapy for pathogenic infection.

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AIE Featured Inorganic–Organic Core@Shell Nanoparticles for High-Efficiency siRNA Delivery and Real-Time Monitoring

Cited by 60 publications

References 50 publications

A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy

A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy

Promising Applications of AIEgens in Animal Models

AIE-based theranostic systems for detection and killing of pathogens

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