A single-step multicomponent synthesis of a quinoline derivative and the characterization of its cyclodextrin inclusion complex

Pinto, Luciana Matos Alves; Adeoye, Oluwatomide; Thomasi, Sérgio Scherrer; Francisco, Ana Paula; Cabral-Marques, Helena

doi:10.1016/j.molstruc.2021.130391

Cited by 5 publications

(1 citation statement)

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“…Multicomponent reaction (MCR) corresponds to convergent reactions in which three or more starting materials react in a single step to form a product. In discovering and developing new drugs, MCRs offer several advantages over traditional synthesis, such as shorter experimentation time, fewer laboratory techniques and solvents used, and the generation of smaller amounts of waste (3). Thus, the multicomponent reaction method is in accordance with the principles of green chemistry.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of the Polyhydroquinoline Derivative 4-(2-Chloro-Phenyl)-2,7,7-Trimethyl5-oxo-1,4,5,6,7,8-Hexahydroquinoline-3-Carboxylic Acid Ethyl Ester: Antimicrobial and Enzyme Modulator

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et al. 2021

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Multicomponent reactions are extremely relevant in green chemistry. They offer better conditions than traditional synthesis and are, therefore, used for many organic modifications. Recently, the synthesis of polyhydroquinolines has received much attention for its high pharmacological potential. In the present study, a polyhydroquinoline derivative was synthesized without the use of catalysts or solvents. The results of nuclear magnetic resonance and infrared spectroscopy demonstrated that the molecule was successfully synthesized. The molecule presents significant results of antimicrobial activity for the bacteria tested in the serial dilution method. It also increased the clotting time by 25.66 seconds for the highest dose and 12.66 seconds for the other doses tested. Prior incubation with the dose of 125 mg reduced the thrombolytic activity to 73%. The 125, 100, and 50 mg doses previously incubated with Bothrops moojeni venom inhibited approximately 30% of the phospholipase activity. The molecule was also able to reduce the cytotoxicity induced by proteases significantly. In conclusion, the molecule presents several biological properties, which highlights its pharmaceutical potential.

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Section: Introductionmentioning

confidence: 99%