A simple and rapid high-performance liquid chromatographic method for the determination of bisoprolol fumarate and hydrochlorothiazide in a tablet dosage form

Shaikh, Saleem; Thusleem, O.A.; Muneera, M.S.; Akmal, Javeed; Kondaguli, Anand V.; Ruckmani, K.

doi:10.1016/j.jpba.2008.08.009

Cited by 51 publications

(28 citation statements)

References 7 publications

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“…The method was validated according to ICH guidelines and the acceptance criteria for accuracy, precision, linearity, specificity and system suitability were met in all cases. The method was linear in the range of 50-150 µg/ml for BF and 125-375 µg/ml for HCTZ [29].…”

Section: Chromatographic Methods 341 High Performance Liquid Chromatmentioning

confidence: 96%

Analytical Techniques for Determination of Hydrochlorothiazide and its Combinations: A Review

Savaj¹,

Patidar²,

Raj³

2015

Int J of Adv in Sci Res

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Hydrochlorothiazide is chemically 6-chloro-1, 1-dioxo-3, 4-dihydro-2H-1, 2, 4-benzothiadiazine-7-sulfonamide. Hydrochlorothiazide is a diuretic drug used for treatment of high blood pressure (hypertension) and accumulation of fluid (edema). It works by blocking salt and fluid reabsorption from the urine in the kidneys, causing increased urine output (dieresis). Hydrochlorothiazide is used to treat excessive fluid accumulation and swelling (edema) of the body caused by heart failure, cirrhosis, chronic kidney failure, corticosteroid medications, and nephrotic syndrome. It can be used alone or in conjunction with other blood pressure lowering medications to treat high blood pressure.This review focuses on the recent developments in analytical techniques for estimation of Hydrochlorothiazide alone or in combinations with other drugs in various biological media like human plasma and urine. This review will critically examine the (a) sample pretreatment method such as solid phase extraction (SPE), (b) separation methods such as thin layer chromatography (TLC), high performance liquid chromatography (HPLC), ultra performance liquid chromatography (UPLC), high performance thin layer chromatography (HPTLC), liquid chromatography coupled to tandem mass spectrometry (LC-MS) and capillary electrophoresis (CE), (c) other methods such as spectrophotometry, diffuse reflectance near infrared spectroscopy and electrochemical methods.

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Section: Chromatographic Methods 341 High Performance Liquid Chromatmentioning

confidence: 96%

Analytical Techniques for Determination of Hydrochlorothiazide and its Combinations: A Review

Savaj¹,

Patidar²,

Raj³

2015

Int J of Adv in Sci Res

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“…2). Previous studies show more Rt than 2.09 and it means that developed method is more rapid [6][7][8][9][10][11][12][13]. The optimum chromatographic conditions and system suitability parameters are tabulated in table 1.…”

Section: Methods Development and Optimizationmentioning

confidence: 99%

“…A literature survey was conducted and several methods were reported for the determination of bisoprolol fumarate, such as spectrophotоmetry [2][3][4][5] and liquid chromatоgraphy [6][7][8][9][10][11][12].…”

Section: Fig 1: Chemical Structure Of Bisoprolol Fumaratementioning

confidence: 99%

Development and Validation of HPLC-Dad Method for the Determination of Bisoprolol in Tablet Dosage Forms

Kondratova¹,

Logoyda

Voloshko³

et al. 2017

Int J App Pharm

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Objective: A rapid, simple and sensitive RP-HPLC method was developed and validated for the determination of bisoprolol fumarate in bulk and pharmaceutical dosage form. ABSTRACT Methods:Chromatographic separation was achieved within 2.5 min on ACQUITY Arc System, Waters Symmetry C18 column (3.9 mm i.d. X 150 mm, 5 μm particle sizes) using a mobile phase consisted of acetonitrile: phosphate buffer (25:75 v/v) in an isocratic mode at a flow rate of 1.4 ml/min. The pH of the mobile phase was adjusted to 7.0 with orthophosphoric acid and UV detection was set at 226 nm. Results:The retention time for bisoprolol fumarate was found to be 2.09 min. The proposed method was validated according to ICH guidelines with respect to linearity, specificity precision, accuracy and robustness. The limit of detection and limit of quantification are calculated and found to be 0.4825 and 1.4621 μg/ml; respectively. Conclusion:The proposed method can help research studies, quality control and routine analysis with lesser resources available. The results of the assay of pharmaceutical formulation of the developed method are highly reliable and reproducible and is in good agreement with the label claim of the medicines.

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“…Therefore, their simultaneous determination is hard by using conventional spectrophotometric techniques. Several methods have been reported for the analysis of BS or HZ alone or in combination with other drugs [2][3][4][5][6][7][8][9][10][11][12][13][14][15] and in their binary mixture using HPLC [16][17][18][19][20][21][22][23]. Both BS and HZ are official in The United States Pharmacopeia [24] and British Pharmacopeia [25].…”

Section: Introductionmentioning

confidence: 99%

“…The proposed HPLC method uses RP 18 column, which is available in many laboratories. However some of the published HPLC methods used cyano column [18] and/or ultra pressure liquid Chromatography (UPLC) [21] which might not be available at some laboratories.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Spectrophotometric Estimation of Bisoprolol Fumarate and Hydrochlorothiazide in Tablet Formulation using Partial Least-Squares, Principal Component Regression Multivariate Calibrations and RP-HPLC Methods

Mostafa

El‐Gindy

Emara

2017

JAPLR

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The UV spectrophotometric analysis of a binary mixture containing bisoprolol fumarate (BS) and hydrochlorothiazide (HZ) by using multivariate calibration methods, such as principal component regression (PCR) and partial least-squares regression (PLS-1); and a graphical spectrophotometric method such as second derivative of the ratio spectra 2 DD was described. A calibration set of 22 reference samples was used to develop the models for PCR and PLS-1. The calibration models optimization was achieved through the proper wavelength ranges selection, and excluding any information about the interfering excipients. In addition, a High Performance Liquid Chromatography (HPLC) was developed to analyze the same mixture. The chromatographic separation was achieved on a reversed phase, RP 18 column with mobile phase consisting of acetonitrile-0.01 M KH2PO4 (40:60, v/v, and pH 3.5). Quantitation was achieved with UV detection at 232 nm based on peak area. The proposed methods were validated and successfully used for the analysis of laboratory-prepared mixtures and pharmaceutical formulations.

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A simple and rapid high-performance liquid chromatographic method for the determination of bisoprolol fumarate and hydrochlorothiazide in a tablet dosage form

Cited by 51 publications

References 7 publications

Analytical Techniques for Determination of Hydrochlorothiazide and its Combinations: A Review

Analytical Techniques for Determination of Hydrochlorothiazide and its Combinations: A Review

Development and Validation of HPLC-Dad Method for the Determination of Bisoprolol in Tablet Dosage Forms

Simultaneous Spectrophotometric Estimation of Bisoprolol Fumarate and Hydrochlorothiazide in Tablet Formulation using Partial Least-Squares, Principal Component Regression Multivariate Calibrations and RP-HPLC Methods

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