A Simple and Convenient Method for the Reduction of Nitroarenes*

Kanth, S. Ravi; Reddy, G. Venkat; Rao, V. Venkat; Maitraie, D.; Narsaiah, B.; Rao, P. Srinivasa

doi:10.1081/scc-120006470

Cited by 11 publications

(2 citation statements)

References 8 publications

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“…Although there are some processes to reduce the nitroarenes, such as reduction of metals, catalytic hydrogenation reduction, , sulfide reduction, − hydration hydrazine reduction, − and electrochemical reduction, the most prevalent industrial process is still iron powder reduction until now. The solvent for this process is usually methanol–water or ethanol–water solvent mixtures and water plays an important role in the reduction process. , However, solubility data of CDMB and CDMA in methanol–water and ethanol–water solvent mixtures have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Solubility of 4-Chloro-2,5-dimethoxynitrobenzene, 4-Chloro-2,5-dimethoxyaniline, and 2,5-Dimethoxyaniline in Binary and Pure Solvents: Determination and Modeling

Liu

et al. 2019

J. Chem. Eng. Data

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Using the dynamic method over the temperature range of (277 to 340) K at atmosphere pressure, solubility of 4-chloro-2,5-dimethoxynitrobenzene (CDMB) and 4-chloro-2,5-dimethoxyaniline (CDMA) in methanol–water and ethanol–water solvent mixtures, where solute-free mass fraction of methanol and ethanol range from 0.2 to 0.8, and solubility of CDMB, CDMA, and 2,5-dimethoxyaniline (DMAn) in 2-methoxyethanol, 2-ethoxyethanol, 1-methoxy-2-propanol, and diethylene glycol have been investigated. In all solvents, there exists a direct relationship between solubility and temperature. In mixture solvents, the experimental data are correlated using the Wilson and the NRTL models. The solubility of CDMB and CDMA increases with the added amount of methanol or ethanol. In pure organic solvents, significant differences are discerned for the solubility of CDMB, CDMA, and DMAn, and data are correlated with the Wilson, the NRTL, the modified Apelblat, and the λh models. The solubility of DMAn is strongly dependent on temperature, whereas CDMB is weakly dependent. On the basis of the solubility data and the solubility differences among CDMB, CDMA, and DMAn, ethanol–water solution is preferred to be the solvent for the reduction of CDMB, and diethylene glycol is suggested to be the recrystallization solvent used to separate DMAn from the system.

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Section: Introductionmentioning

confidence: 99%

Solubility of 4-Chloro-2,5-dimethoxynitrobenzene, 4-Chloro-2,5-dimethoxyaniline, and 2,5-Dimethoxyaniline in Binary and Pure Solvents: Determination and Modeling

Liu

et al. 2019

J. Chem. Eng. Data

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“…However 3-aminopyrazolo [3,4-b]pyridines have not been exploited so far as starting materials for aza-Diels Alder type reactions. Due to our continued interest [14][15][16][17] in synthesis of novel ring systems, we report here for the first time synthesis of new pyrido[2 0 ,3 0 :3,4]pyrazolo [1,5-a]pyrimidines/quinazolines by formal aza-Diels Alder type reaction of 3-aminopyrazolo [3,4-b]pyridine with formaldehyde/benzaldehyde and various electron rich alkenes.…”

Section: Introductionmentioning

confidence: 99%