A “signal-on’’ aptasensor for simultaneous detection of chloramphenicol and polychlorinated biphenyls using multi-metal ions encoded nanospherical brushes as tracers

Yan, Zhongdan; Gan, Ning; De, Wang; Cao, Yuting; Meng, Chen; Li, Tianhua; Yinji, Chen

doi:10.1016/j.bios.2015.07.024

Cited by 65 publications

(26 citation statements)

References 38 publications

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“…It was also implemented in a sensor for the simultaneous detection of chloramphenicol and PCBs in spiked fish samples. Due to the fact that metal ions were used as tracers to determine which of the two targets was being detected, the number of targets that can be analyzed in parallel is limited by the number of applicable ions (Yan et al, 2015 ).…”

Section: Small Molecule Aptasensorsmentioning

confidence: 99%

Selection and Biosensor Application of Aptamers for Small Molecules

2016

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Small molecules play a major role in the human body and as drugs, toxins, and chemicals. Tools to detect and quantify them are therefore in high demand. This review will give an overview about aptamers interacting with small molecules and their selection. We discuss the current state of the field, including advantages as well as problems associated with their use and possible solutions to tackle these. We then discuss different kinds of small molecule aptamer-based sensors described in literature and their applications, ranging from detecting drinking water contaminations to RNA imaging.

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Section: Small Molecule Aptasensorsmentioning

confidence: 99%

Selection and Biosensor Application of Aptamers for Small Molecules

2016

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“…Yan et al [170] introduced a "signal-on" electrochemical aptasensor for the simultaneous detection of chloramphenicol and polychlorinated biphenyl-72 (PCB72) using multi-metal ions encoded nanospherical brushes as tracers. For formation of the capture probe, the respective aptamers of chloramphenicol and PCB72 were labelled on magnetic AuNPs.…”

Section: Chloramphenicolmentioning

confidence: 99%

Aptamer-based Biosensors for Antibiotic Detection: A Review

Mehlhorn

Rahimi

Joseph

2018

Preprint

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Antibiotic resistance and accordingly their pollution because of uncontrolled usage has emerged as a serious problem in recent years. Hence, there is an increased demand to develope robust, easy, and sensitive methods for rapid evaluation of antibiotic and their residues. Among different analytical methods, the aptamer-based biosensors (aptasensors) have attracted considerable attention because of good selectivity, specificity, and sensitivity. This review gives an overview about recent developed aptasensors for antibiotic detection. The use of various aptamer assays to determine different groups of antibiotics like β-lactams, Aminoglycosides, Anthracyclines, Chloramphenicol, (Fluoro)Quinolones, Lincosamide, Tetracyclines and Sulfonamides are presented in this paper.

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“…Furthermore, aptamers are cost-effective, easily prepared, reproducible, animal-friendly and nonimmunogenic 9 . Up to date, few studies have been reported for the selective detection of PCBs using an aptamer biosensor because PCBs are stable unreactive chemical compounds 10 .…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles dotted Reduction Graphene Oxide Nanocomposite Based Electrochemical Aptasensor for Selective, Rapid, Sensitive and Congener-Specific PCB77 Detection

et al. 2017

Sci Rep

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Gold nanoparticles (AuNP) dotted reduction graphene oxide (RGO-AuNP) is used as a platform for an aptamer biosensor to selectively detect 3,3′4,4′-polychlorinated biphenyls (PCB77). By anchoring aptamers onto the binding sites of RGO-AuNP and making use of the synergy effect of RGO and AuNP, the RGO-AuNP based biosensor exhibits superior analytical performances to AuNP based biosensor in terms of sensitivity and repeatability. The sensitivity of RGO-AuNP based aptamers (RGO-AuNP-Ap) biosensor (226.8 μA cm−2) is nearly two times higher than that of Au based biosensors (AuNP-Ap/Au electrode, 147.2 μA cm−2). The RGO-AuNP-Ap/Au biosensor demonstrated a linear response for PCB77 concentrations between 1 pg L−1 and 10 μg L−1, with a low limit of detection (LOD) of 0.1 pg L−1. The superb LOD satisfies the exposure thresholds (uncontaminated water < 0.1 ng L−1) set out by International Agency for Research on Cancer (IARC) and the Environmental Protection Agency (EPA). The proposed biosensor can be a powerful tool for rapid, sensitive and selective detection of PCBs on site.

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A “signal-on’’ aptasensor for simultaneous detection of chloramphenicol and polychlorinated biphenyls using multi-metal ions encoded nanospherical brushes as tracers

Cited by 65 publications

References 38 publications

Selection and Biosensor Application of Aptamers for Small Molecules

Selection and Biosensor Application of Aptamers for Small Molecules

Aptamer-based Biosensors for Antibiotic Detection: A Review

Gold Nanoparticles dotted Reduction Graphene Oxide Nanocomposite Based Electrochemical Aptasensor for Selective, Rapid, Sensitive and Congener-Specific PCB77 Detection

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