A short review of drug–food interactions of medicines treating overactive bladder syndrome

Abstract

Background Overactive bladder syndrome is a condition where one or more of the symptoms such as pollakiuria, urgent need to urinate, nocturia and urinary incontinence is observed. Its prevalence ranges between 7 and 27 % in men and 9–43 % in women. The role of a pharmacist is to educate the patient on medications administration scheme, and drug interactions with particular food or food components. Aim of the review To assess a potential impact of food and fruit juice on the pharmacokinetic and therapeutic effects of medications used in treating overactive bladder syndrome. This information will enhance pharmaceutical care and is vital and helpful for pharmacists counseling their patients. Method In order to gather information on interactions of medications employed in bladder dysfunctions, the English language reports published in the PubMed, Embase, Cochrane and CINAHL database over the years 1996–2015 were studied. Additionally, other resources, namely drugs.com, Medscape, UpToDate, Micromedex, Medical Letter, as well as Stockley Drugs Interaction electronic publication were included in the study. The analysis also covered product data sheets for particular medicinal products. Results Meals and the consumption of grapefruit juice were found to exert a diversified effect on the pharmacokinetics of drugs employed in overactive bladder syndrome therapy. Neither tolterodine, nor mirabegron interact with food and citrus fruit juice, whereas darifenacin, fesoterodine, oxybutynin and solifenacin do interact with grapefruit and others citrus fruit juice. The effects of such interactions may potentially be negative to patients. Trospium absorption is significantly decreased by food. Conclusion For selected medicines used in treating bladder dysfunctions food and grapefruit juice consumption may significantly affect efficacy and safety of the therapy. All information on the topic is likely to enhance the quality of pharmaceutical care.

The Effect of Grapefruit Juice on the Pharmacokinetics of Tadalafil in Rats

“…Specific medicinal substances, or supplements, consumed with food may significantly affect the efficacy and safety of the therapy. Gaps in knowledge on interactions especially with respect to the consequences of food-drug interactions are evident [23].…”

Protein Considerations for Athletes With a Spinal Cord Injury

“…Second, neurogenic bladder and associated complications could have implications on dietary protein intakes (e.g., decreased intake), as it seems possible that a high-protein diet might have some negative consequences in patients with kidney disease (43). In addition, bladder overactivity treated with anticholinergics can further diminish GI motility and affect diet due to food-drug interactions (44). Athletes should undergo a yearly medical screening including a check of bladder and kidney function, if they are considering a higher-protein diet.…”

Diet in neurogenic bowel management: A viewpoint on spinal cord injury

“…When including natural health products, vitamins and minerals, polypharmacy was present in 74% of patients with SCI [88] . In particular, NB can be observed in individuals with SCI treated with drugs metabolized by CYP3A4 (oxybutynin, solifenacin and darifenacin) [89] . Therefore, caution has been recommended when simultaneously consuming grapefruit juice during treatment with these drugs [89] .…”

“…In particular, NB can be observed in individuals with SCI treated with drugs metabolized by CYP3A4 (oxybutynin, solifenacin and darifenacin) [89] . Therefore, caution has been recommended when simultaneously consuming grapefruit juice during treatment with these drugs [89] . Other citrus fruit juices, cruciferous vegetables (broccoli, cabbage, and daikon radish sprouts), soy foods (soy milk, veggies slices, tofu, and roasted soy nuts), tea and cranberry and pomegranate juices can induce adverse food-drug interactions and should be avoided in individuals in treatment for comorbidity [70,90] .…”