Diet in neurogenic bowel management: A viewpoint on spinal cord injury

Bernardi, Marco; Fedullo, Anna Lucia; Bernardi, Elisabetta; Munzi, Diego; Peluso, Ilaria; Myers, Jonathan A.; Lista, Florigio; Sciarra, Tommaso

doi:10.3748/wjg.v26.i20.2479

Cited by 44 publications

(40 citation statements)

References 155 publications

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“…Mediterranean lifestyle habits include diet, physical activity, and social interaction [ 45 ], and some Mediterranean pyramids include emotional balance [ 46 , 47 ] or psychological wellness [ 48 ], all factors that can be influenced by lockdown. A recent review revealed more frequent snack consumption and a rise in the intake of carbohydrates with a high glycemic index during the COVID-19 pandemic [ 49 ].…”

Section: Lockdown Lifestyle and Diabesity: Implications For Pregnmentioning

confidence: 99%

Mediterranean Diet for the Prevention of Gestational Diabetes in the Covid-19 Era: Implications of Il-6 In Diabesity

Fedullo¹,

Schiattarella

Morlando

et al. 2021

IJMS

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The aim of this review is to highlight the influence of the Mediterranean Diet (MedDiet) on Gestational Diabetes Mellitus (GDM) and Gestational Weight Gain (GWG) during the COVID-19 pandemic era and the specific role of interleukin (IL)-6 in diabesity. It is known that diabetes, high body mass index, high glycated hemoglobin and raised serum IL-6 levels are predictive of poor outcomes in coronavirus disease 2019 (COVID-19). The immunopathological mechanisms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection include rising levels of several cytokines and in particular IL-6. The latter is associated with hyperglycemia and insulin resistance and could be useful for predicting the development of GDM. Rich in omega-3 polyunsaturated fatty acids, vitamins, and minerals, MedDiet improves the immune system and could modulate IL-6, C reactive protein and Nuclear Factor (NF)-κB. Moreover, polyphenols could modulate microbiota composition, inhibit the NF-κB pathway, lower IL-6, and upregulate antioxidant enzymes. Finally, adhering to the MedDiet prior to and during pregnancy could have a protective effect, reducing GWG and the risk of GDM, as well as improving the immune response to viral infections such as COVID-19.

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Section: Lockdown Lifestyle and Diabesity: Implications For Pregnmentioning

confidence: 99%

Mediterranean Diet for the Prevention of Gestational Diabetes in the Covid-19 Era: Implications of Il-6 In Diabesity

Fedullo¹,

Schiattarella

Morlando

et al. 2021

IJMS

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“…The dietary advice for individuals with SCI included Mediterranean diet [ 46 ] and an anti-inflammatory diet [ 47 ]. The latter was able to increase (after 3 months) the intake of vitamins C (ascorbic acid) and E (alpha-tocopherol) in individuals with SCI, where proinflammatory markers were negatively correlated with carotenoids [ 47 ].…”

Section: Dietary Antioxidants In Spinal Cord Injurymentioning

confidence: 99%

Hormetic Effects of Bioactive Compounds from Foods, Beverages, and Food Dressing: The Potential Role in Spinal Cord Injury

Fedullo

Ciccotti²,

Giannotta³

et al. 2021

Oxidative Medicine and Cellular Longevity

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Spinal cord injury (SCI) is a damage or trauma to the spinal cord resulting in a total or partial loss of motor and sensory function. SCI is characterized by a disequilibrium between the production of reactive oxygen species and the levels of antioxidant defences, causing oxidative stress and neuroinflammation. This review is aimed at highlighting the hormetic effects of some compounds from foods, beverages, and food dressing that are able to reduce oxidative stress in patients with SCI. Although curcumin, ginseng, and green tea have been proposed for SCI management, low levels of antioxidant vitamins have been reported in individuals with SCI. Mediterranean diet includes food rich in vitamins and antioxidants. Moreover, food dressing, including spices, herbs, and extra virgin olive oil (EVOO), contains multiple components with hormetic effects. The latter involves the activation of the nuclear factor erythroid-derived 2, consequently increasing the antioxidant enzymes and decreasing inflammation. Furthermore, EVOO improves the bioavailability of carotenoids and could be a delivery system for bioactive compounds. In conclusion, Mediterranean dressing in addition to plant foods can have an important effect on redox balance in individuals with SCI.

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“…Intersubjects' variability has been reported for absorption, metabolism, and excretion of CB polyphenols in healthy individuals, partly due to the variation in the gut microbiota [32]. Several studies have reported different intestinal microbiota in individuals with SCI compared to healthy controls [33], and diet is known to influence gut microbiota [33] and to affect UTI risk [34]. Therefore, monitoring food consumption is of great importance in those studies aimed at evaluating the effects of bioactive compounds from plant food.…”

Section: Completeness Quality and Applicability Of Evidencementioning

confidence: 99%

Cranberry for Bacteriuria in Individuals with Spinal Cord Injury: A Systematic Review and Meta-Analysis

Raguzzini

Toti

Sciarra³

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. Urinary tract infection (UTI) is common in individuals with spinal cord injury (SCI) and neurogenic lower urinary tract dysfunction (NLUTD) and in veterans with SCI who use antibiotics improperly for asymptomatic bacteriuria. Cranberry (CB) has been suggested for UTI prevention. Methods. We performed a systematic search up to May 2020 in the following databases: AccessMedicine, BioMed Central, CINAHL, Cochrane Library, ProQuest, and PubMed. Quality assessment was performed using a specifically designed quality score. Risk ratio was calculated with both random effect model analysis (DerSimonian-Laird method) and quality effect model analysis (Doi Thalib method). Results. Six studies on bacteriuria and SCI were reviewed. From the four studies available for meta-analysis, two of which with individuals taking both CB and control, 477 data from 415 participants were analysed (241 CB and 236 control). No significant differences were detected with meta-analysis. However, bias, limitations, and incompleteness were observed in the reviewed studies. Conclusion. Although further studies are needed, we suggest an accurate monitoring of diet and fluid intake, the evaluation of risk for potential food or nutraceutical interactions with drugs, and the inclusion of inflammatory markers among the outcomes in addition to UTI.

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Diet in neurogenic bowel management: A viewpoint on spinal cord injury

Cited by 44 publications

References 155 publications

Mediterranean Diet for the Prevention of Gestational Diabetes in the Covid-19 Era: Implications of Il-6 In Diabesity

Mediterranean Diet for the Prevention of Gestational Diabetes in the Covid-19 Era: Implications of Il-6 In Diabesity

Hormetic Effects of Bioactive Compounds from Foods, Beverages, and Food Dressing: The Potential Role in Spinal Cord Injury

Cranberry for Bacteriuria in Individuals with Spinal Cord Injury: A Systematic Review and Meta-Analysis

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