A “Ship in a Bottle” Strategy To Load a Hydrophilic Anticancer Drug in Porous Metal Organic Framework Nanoparticles: Efficient Encapsulation, Matrix Stabilization, and Photodelivery

Abstract

An essential challenge in the development of nanosized metal organic framework (nanoMOF) materials in biomedicine is to develop a strategy to stabilize their supramolecular structure in biological media while being able to control drug encapsulation and release. We have developed a method to efficiently encapsulate topotecan (TPT, 1), an important cytotoxic drug, in biodegradable nanoMOFs. Once inside the pores, 1 monomers aggregate in a "ship in a bottle" fashion, thus filling practically all of the nanoMOFs' available free volume and stabilizing their crystalline supramolecular structures. Highly efficient results have been found with the human pancreatic cell line PANC1, in contrast with free 1. We also demonstrate that one- and two-photon light irradiation emerges as a highly promising strategy to promote stimuli-dependent 1 release from the nanoMOFs, hence opening new standpoints for further developments in triggered drug delivery.

Nanomedicine Applications of Hybrid Nanomaterials Built from Metal–Ligand Coordination Bonds: Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers

“…161 Cytotoxicity assays in HepG2 and MCF-7 cells showed that AL-UiO-66 NMOFs induced enhanced cell killing than free AL. The delivery of camptothecin (CPT) and its derivative Topotecan (TPT) was achieved by ZIF-8 (∼70 nm) 162 and MIL-100 (∼50−100 nm), 163 respectively. Both drug loaded NMOFs exhibited enhanced cytotoxicity against cancer cells as compared to free drugs.…”

Efficient multicolor and white light emission from Zr-based MOF composites: spectral and dynamic properties

“…[11][12][13] Others have been designed to emit white light for developing white light emitting devices (WLEDs). 18,19 The formed host-guests composites materials can exhibit different photoevents processes as charge-and energy-transfer (CT, ET). 16,17 For both MOFs, the immobilization of the organic linkers by its incorporation into the network leads to an increase in the internal as well as external quantum yields, improving their photoluminescence properties, like luminescent and moisture stability and color tunability.…”

Zeolitic Imidazole Framework (ZIF) Nanospheres for Easy Encapsulation and Controlled Release of an Anticancer Drug Doxorubicin under Different External Stimuli: A Way toward Smart Drug Delivery System

“…16 Other than these, the microenvironment of MOFs which are either hydrophilic or hydrophobic gives them ability to encapsulate both lipophilic as well as lipophobic drugs. 17 Different types of forces play an important role for drug loading and its release. These forces can be Van Der Waals force, hydrogen bonds, coordination bond, pi-pi interactions, electrostatic interaction etc.…”