Nanomedicine Applications of Hybrid Nanomaterials Built from Metal–Ligand Coordination Bonds: Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers

He, Chunbai; Liu, Demin; Lin, Wenbin

doi:10.1021/acs.chemrev.5b00125

Cited by 877 publications

(534 citation statements)

References 248 publications

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“…However, most previously published MOF structures (such as Cr‐, Co‐, and Ni‐based MOFs) are not suitable for bioapplications due to their disadvantages including biological toxicity and bioinstability, as hydrolysis or decomposition even can occur in the presence of moisture 9, 10, 11, 12, 13, 14. Recently, nanoscale metal–organic particles, which have been designed for biomedicine applications by judiciously selecting inorganic and organic building blocks, have shown great potential for drug delivery, photodynamic therapy (PDT), photothermal therapy, nucleic acid delivery, and biomedical imaging 15, 16, 17. Therefore, MOPs provide a new direction for developing DDSs.…”

Section: Introductionmentioning

confidence: 99%

Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle‐Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy

Zhang

Cai

et al. 2018

Advanced Science

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A novel metal–organic particle (MOP) based nanodrug formed by mild self‐assembly of chemotherapeutic drugs, including banoxantrone and doxorubicin, through Cu(II)‐mediated coordination effects, is reported. In this nanodrug, Cu(II) acts as a bridge to join AQ4N and DOX, and then, self‐assembly of [‐AQ4N‐Cu(II)‐(DOX)2‐Cu(II)‐]n complexes forms nanosized MOPs (referred to as ADMOPs) through multiple interactions including host–metal–guest coordination, hydrophobic interactions, π‐stacking, and van der Waals force. The ADMOPs reported here have several important features over conventional drugs, including tumor microenvironment pH‐sensitive drug release that can be tracked by “turning on” the fluorescence of AQ4N or DOX through proton competition with Cu(II) to break the coordination bonds and much deeper penetration into solid tumors via microvesicle‐mediated intercellular transfer. Most strikingly, the ADMOPs can serve as stimuli‐responsive nanocarriers to efficiently load the photosensitizer phthalocyanine due to their inherent highly porous characteristics. Thus, the ADMOPs significantly enhance the chemotherapeutic efficacy by “on‐demand” photodynamic therapy, which further induces a hypoxic environment that enhances the reduction of AQ4N to systematically increase the therapeutic efficiency. Taken together, the designed ADMOPs composed of chemotherapeutic drugs may serve as a potential programmable controlled synergistic agent for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle‐Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy

Zhang

Cai

et al. 2018

Advanced Science

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“…In recent years, various crystalline metal-organic architectures (MOAs) including coordination polymers (CPs) or metal-organic frameworks (MOFs) have been an object of very intense research that spans from the fields of crystal design and engineering to chemistry of functional materials [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. In particular, a very interesting research direction concerns the search for new and versatile organic building blocks that can be applied for the design of unusual metal-organic architectures with desirable structural features and notable functional properties [16][17][18][19].…”

Section: Introduction and Scopementioning

confidence: 99%

Multifunctional Aromatic Carboxylic Acids as Versatile Building Blocks for Hydrothermal Design of Coordination Polymers

Wen

Liang

et al. 2018

Crystals

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Abstract:Selected recent examples of coordination polymers (CPs) or metal-organic frameworks (MOFs) constructed from different multifunctional carboxylic acids with phenyl-pyridine or biphenyl cores have been discussed. Despite being still little explored in crystal engineering research, such types of semi-rigid, thermally stable, multifunctional and versatile carboxylic acid building blocks have become very promising toward the hydrothermal synthesis of metal-organic architectures possessing distinct structural features, topologies, and functional properties. Thus, the main aim of this mini-review has been to motivate further research toward the synthesis and application of coordination polymers assembled from polycarboxylic acids with phenyl-pyridine or biphenyl cores. The importance of different reaction parameters and hydrothermal conditions on the generation and structural types of CPs or MOFs has also been highlighted. The influence of the type of main di-or tricarboxylate ligand, nature of metal node, stoichiometry and molar ratio of reagents, temperature, and presence of auxiliary ligands or templates has been showcased. Selected examples of highly porous or luminescent CPs, compounds with unusual magnetic properties, and frameworks for selective sensing applications have been described.

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“…They can either be built from Ln cations or serve as host structures, in which the Ln cations can be incorporated into the connectivity centers or inside the pores of the MOF [26,27]. Their highly porous and oriented structures, which allow them to accommodate many different cargoes, and their intrinsic biodegradability make them interesting materials for biomedical applications, especially for sensing and delivery [28].…”

Section: Introductionmentioning

confidence: 99%

Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications

et al. 2017

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Abstract:Rare earth based nanostructures constitute a type of functional materials widely used and studied in the recent literature. The purpose of this review is to provide a general and comprehensive overview of the current state of the art, with special focus on the commonly employed synthesis methods and functionalization strategies of rare earth based nanoparticles and on their different bioimaging and biosensing applications. The luminescent (including downconversion, upconversion and permanent luminescence) and magnetic properties of rare earth based nanoparticles, as well as their ability to absorb X-rays, will also be explained and connected with their luminescent, magnetic resonance and X-ray computed tomography bioimaging applications, respectively. This review is not only restricted to nanoparticles, and recent advances reported for in other nanostructures containing rare earths, such as metal organic frameworks and lanthanide complexes conjugated with biological structures, will also be commented on.

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Nanomedicine Applications of Hybrid Nanomaterials Built from Metal–Ligand Coordination Bonds: Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers

Cited by 877 publications

References 248 publications

Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle‐Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy

Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle‐Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy

Multifunctional Aromatic Carboxylic Acids as Versatile Building Blocks for Hydrothermal Design of Coordination Polymers

Rare earth based nanostructured materials: synthesis, functionalization, properties and bioimaging and biosensing applications

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