A sequential injection analysis system for potassium clavulanate determination using two potentiometric detectors

Pimenta, Adriana M.; Araújo, Alberto N.; Montenegro, M.C.B.S.M.

doi:10.1016/s0731-7085(02)00474-0

Cited by 16 publications

(4 citation statements)

References 15 publications

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“…These injection volumes were obtained for a maximum flow rate of 1.5 ml·min -1 for both potentiometric detectors. The increments in the flow rate carried an appreciable loss of signal repeatability, possibly caused by inertia to the flow during the aspiration stage, and by the dynamic response characteristics of each electrode type used [30].…”

Section: Behaviour Of the Electrodes In The Sia Systemmentioning

confidence: 99%

Sequential Injection Analysis of Ampicillin in Pharmaceuticals by Using Potentiometric Detectors Based on PVC and Sol-Gel Membranes

Zárate¹,

Araújo²,

Montenegro³

et al. 2011

AJAC

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This work describes the construction and the evaluation of the general performance of new ampicillinate-selective electrodes based on manganese (III) tetraphenylporphyrin [Mn(III) TPP-Cl] as ionophore, incorporated in both PVC and sol-gel membranes and directly applied onto a conductive graphite/epoxy resin support. The units were constructed without inner reference solution adopting conventional configuration and in the case of PVC membrane the tubular configuration was also adopted. The good working characteristics of these electrodes, made possible its application to the determination of ampicillin in pharmaceuticals formulations, both in conventional batch analysis and in flow conditions, when the electrodes were coupled to a SIA system. In the last case the potentiometric sensors presented linear response towards ampicillin concentration between 5.0 × 10 -4 and 5.0 × 10 -2 mol·l -1 with slopes of -57.4 and -63.5 mV·dec -1 for the PVC and sol-gel membranes, respectively. The developed procedures enable mean relative standard deviations better than 3% for all the samples analysed. The obtained results do not statistically differ from those furnished by applying the HPLC reference method.

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Section: Behaviour Of the Electrodes In The Sia Systemmentioning

confidence: 99%

Sequential Injection Analysis of Ampicillin in Pharmaceuticals by Using Potentiometric Detectors Based on PVC and Sol-Gel Membranes

Zárate¹,

Araújo²,

Montenegro³

et al. 2011

AJAC

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“…Several analytical techniques have been applied for AMX and CLA determination in pharmaceutical and biological Abbreviations: AMX, amoxicillin; C 4 samples, such as HPLC [3][4][5][6], TLC with densitometric detection [7], UHPLC-MS/MS [8], CE with UV detection [9,10], MS [11], spectrophotometry [12,13], chemiluminescence [14], attenuated total reflectance with FTIR spectroscopy [15], sequential injection analysis [16][17][18], FIA [19], and stopped-flow techniques [20,21]. Most of the reported methods generally require expensive instrumentation and are time-consuming, which is undesirable in quality control activities.…”

Section: Introductionmentioning

confidence: 99%

Single‐run capillary electrophoresis method for the fast simultaneous determination of amoxicillin, clavulanate, and potassium

Marra

Cunha

Muñoz

et al. 2017

J of Separation Science

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We report a new fast method for the simultaneous determination of amoxicillin, clavulanate, and potassium by capillary electrophoresis with capacitively coupled contactless conductivity detection. Samples containing potassium as the cation, and both amoxicillin and clavulanate as anions were determined simultaneously in a single run (in less than 45 s) using 10 mmol/L of both 2-amino-2-hydroxymethyl-propane-1,3-diol and 3-{[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino}-1-propanesulfonic acid (pH 8.4) as the background electrolyte. Limits of detection were 25.0, 5.0, and 4.0 μmol/L for amoxicillin, clavulanate, and potassium, respectively. The proposed method is inexpensive, simple, fast (75 injections h ), environment friendly (minimal waste generation), and accurate (recovery values between 98 and 103%). The results obtained with the proposed method were statistically similar (95% confidence level) to those obtained by using high-performance liquid chromatography (amoxicillin and clavulanate) and flame photometry (potassium).

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“…Taking into account that random errors should not affect both measurements with the same sign and magnitude and that the systematic deviations are different in both methods, the value corresponding to their mean is a more accurate estimate of the analyte concentration in the sample. Other figures of merit of flow systems implementing this concept are the low consumption of reagents and high sampling rate, thus rendering good analytical tools for process control [5]. In this paper, the application of the concept of real time accuracy assessment in a SIA system is proposed by using two chemical sensors based on the same recognition element, employing, however, two different transduction procedures (potentiometric and optical).…”

Section: Introductionmentioning

confidence: 99%

Chloride-selective membrane electrodes and optodes based on an indium(III) porphyrin for the determination of chloride in a sequential injection analysis system

Pimenta

Araújo

Montenegro

et al. 2004

Journal of Pharmaceutical and Biomedical Analysis

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A sequential injection analysis system for potassium clavulanate determination using two potentiometric detectors

Cited by 16 publications

References 15 publications

Sequential Injection Analysis of Ampicillin in Pharmaceuticals by Using Potentiometric Detectors Based on PVC and Sol-Gel Membranes

Sequential Injection Analysis of Ampicillin in Pharmaceuticals by Using Potentiometric Detectors Based on PVC and Sol-Gel Membranes

Single‐run capillary electrophoresis method for the fast simultaneous determination of amoxicillin, clavulanate, and potassium

Chloride-selective membrane electrodes and optodes based on an indium(III) porphyrin for the determination of chloride in a sequential injection analysis system

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