A semi-quantitative World Health Organization grading scheme evaluating worst tumor differentiation predicts disease-free survival in oral squamous carcinoma patients

Jain, Dhruv; Tikku, Gargi; Bhadana, Pallavi; Dravid, Chandrashekhar; Grover, Rajesh K.

doi:10.1016/j.anndiagpath.2017.04.003

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…The correct diagnosis of the different stages of OSCC patients played a significant role in the management and prognosis. 14,15 Although there were Table 3 The results of the classification of different T stage groups numerous algorithms to analyze and classify the spectral data, 6,[16][17][18] the PCA-LDA was mostly employed in the classification of Raman spectra and had a perfect performance. 2,7,19 In this study, it was the first time to classify and diagnose the different TNM stages and histologic grades of OSCC by using SERS and PCA-LDA based on the serum samples.…”

Section: Discussionmentioning

confidence: 99%

Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for tumor stages detection and histologic grades classification of oral squamous cell carcinoma

Xue

Yan²,

et al. 2018

IJN

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BackgroundTumor stages detection and histologic grades classification are essential for the diagnosis and prognosis of oral squamous cell carcinoma (OSCC). In this research, we apply surface-enhanced Raman spectroscopy (SERS) of blood serum to detect the tumor stages and histologic classification of OSCC.MethodsAccording to TNM classification and World Health Organization histologic grading system, the blood serum samples were collected from a total of 135 OSCC patients in the different tumor stages and histologic grades. Then the SERS spectra of serum samples from OSCC patients were diagnosed and classified into different groups using principal component analysis (PCA) and linear discriminant analysis (LDA) based on the tumor sizes, lymph node metastasis and histologic grades.ResultsThe SERS spectra of blood serum samples have shown the distinct changes and differences compared with each other, which were assigned to the biomolecule alterations (nucleic acids, proteins, lipids, and so on) in blood serums. And all accuracies of detection and classification reached above 85%.ConclusionThis study demonstrated that the SERS based on blood serum test had an enormous potential to carry out the preoperative assessment and prediction of the OSCC patients in different tumor stages and histologic classification.

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Section: Discussionmentioning

confidence: 99%

Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for tumor stages detection and histologic grades classification of oral squamous cell carcinoma

Xue

Yan²,

et al. 2018

IJN

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“…To avoid bias, each section was evaluated by two observers and then jointly by consensus. Based on previous literature worst pattern of invasion (WPOI) was determined [12,13]. In type 1 pattern tumor invades stroma in broad pushing manner, in type 2 pattern tumor invades stroma in solid cords and strands (finger-like), type 3 pattern presents as invasive islands of less than 15 tumor cells clusters, type 4 pattern presents as invasive islands of more than15 tumor cells clusters, type 5 pattern shows tumor islands more than 1 mm away from the progressive end of the tumor or presence of extra tumoral perineural invasion.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Tumour Budding in Head and Neck Squamous Cell Carcinoma and Its Relationship with other Histological Parameters of Prognosis

Ghosh,

Guha

2023

Asian Pac J Cancer Biol

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Background: Tumor budding (TB) is an emerging and promising histopathological prognostic parameter in oral squamous cell carcinoma (SCC). Tumour budding shows positive correlation with lymph node metastasis, higher pattern of invasion, high grade of tumor and more depth of invasion. These histopathological parameters are associated with poor prognosis, high rate of recurrence and these prognostic factors can be routinely used by clinicians for planning of multimodality treatment. Method: The present study was a cross-sectional study carried out on total of 239 patients with oral squamous cell carcinoma who attended the surgical oncology unit of Kalyan Singh Super Speciality Cancer Institute, Lucknow, Uttar Pradesh, India, from November 2020 to June 2022. Descriptive statistical analysis has been carried out in the present study. We used Fischer Exact Probability test and chi-square test analysis in order to identify relationship between different histological features, significance was considered when p<0.05. Results: Majority of study population (69.87%) were in the age group of less than 54 years of age. Age group (<54years) was significantly associated with tumor budding (p<0.05). Cases diagnosed as moderately differentiated SCC were 68.6 % and well differentiated SCC were 25.1%. 74 cases were associated with high intensity of tumor budding and 59 cases with low intensity of tumor budding (p<0.05). Most common worst pattern of invasion was type 4 (61.9%) followed by type 5 (26.4%), strong statistical association was observed with intensity of tumor budding (p<0.05). Most of the cases exhibited maximum depth of invasion (DOI) >1cm (100 cases). DOI was significantly associated with intensity of tumor budding (p<0.05). Out of 102 involved lymph node cases, 91 cases were associated with tumor budding 55 cases of these associated with high intensity tumor budding. Tumor budding was also significantly associated with lymph node metastasis (p<0.05).Conclusion: Present study showed a strong correlation of tumor budding with lymph node metastasis, depth of invasion and worst pattern of invasion. Thus, this study emphasizes the importance of tumor budding evaluation in routine pathology reporting and similar to depth of invasion TB should be included in AJCC TNM staging.

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The Impact of Peritumoral Retraction Clefting & Intratumoral Eosinophils on Overall Survival in Oral Squamous Carcinoma Patients

Jain

Tikku

Bhadana

et al. 2017

Pathol. Oncol. Res.

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This retrospective study aimed to investigate the impact of peritumoral retraction clefts (RC) and tumor-associated tissue eosinophilia (TATE) as predictors of overall survival (OS) in oral squamous cell carcinoma (OSCC) patients. Their relationships with tumor-factors were also examined. Eighty-seven OSCC cases (pTNM: I + II/III + IV; 32/55), post-curative surgery, comprised the study cohort. Three observers independently estimated the percent RC semi-quantitatively in the selected tumor sections. Additionally, stromal eosinophils were counted in ten consecutive high-power fields of intratumoral and peritumoral regions to evaluate the corresponding TATE. The percent RC ranged between 0% -90% (Mean ± SD: 16 ± 24%; Median: 5%). The stromal eosinophils were greater in peritumoral as compared to intratumoral region. The events of death and tumor recurrence were reached in 16 (18.4%) and 36 (41%) cases respectively. The 3-years OS was 69% [Median OS: 1880 days; Mean follow up: 471(Range; 36-1880) days]. Increased percent RC exhibited relationship with pathologic stage (pTNM III&IV), primary tumor (pT III&IV), tumor depth > 4 mm and categorical tumor recurrence. Additionally, peritumoral eosinophilic infiltrates increased with increasing tumor depths and muscle invasion. Kaplan-Meier curves revealed significantly reduced OS in OSCC cases exhibiting: increased percent RC (>2.5%), mild -moderate/absent intratumoral TATE (versus intense TATE) or categorical tumor recurrence. In subsequent multivariate tests, all the three variables retained significance. Additionally, intraclass correlation coefficient demonstrated acceptable internal consistency for the observers who estimated percent RC. In conclusion, RC and intratumoral TATE proved to be independent predictors of OS in our OSCC cohort. Additionally, increased percent RC pointed towards aggressive tumor behaviour.

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A semi-quantitative World Health Organization grading scheme evaluating worst tumor differentiation predicts disease-free survival in oral squamous carcinoma patients

Cited by 5 publications

References 21 publications

Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for tumor stages detection and histologic grades classification of oral squamous cell carcinoma

Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for tumor stages detection and histologic grades classification of oral squamous cell carcinoma

Evaluation of Tumour Budding in Head and Neck Squamous Cell Carcinoma and Its Relationship with other Histological Parameters of Prognosis

The Impact of Peritumoral Retraction Clefting & Intratumoral Eosinophils on Overall Survival in Oral Squamous Carcinoma Patients

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