Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for tumor stages detection and histologic grades classification of oral squamous cell carcinoma

Xue, Liyan; Yan, Bing; Li, Yi; Tan, Yingyun; Luo, Xianyang; Wang, Min

doi:10.2147/ijn.s167996

Cited by 44 publications

(28 citation statements)

References 26 publications

(55 reference statements)

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“…Xue and Wang have proved that the SERS technique can be applied to analyze and discriminate the OSCC and even the different stages of the tumor. Gold NPs can enhance the intensities of the SERS spectrum enormously when they were added to the serum sample [ 73 ]. A customized gold-NP-reduced graphene-oxide- (AuNPs-rGO-) based bioelectrode has been prepared as an immunosensing platform for electrochemical detection of oral cancer [ 74 ].…”

Section: Gold Nanoparticles For Oral Cancer Diagnosis and Therapymentioning

confidence: 99%

Nanoparticles for Oral Cancer Diagnosis and Therapy

Zheng

Zhou

Yuan

2021

Bioinorganic Chemistry and Applications

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Oral cancer is the sixth most common malignant cancer, affecting the health of people with an unacceptably high mortality rate. Despite numerous clinical methods in the diagnosis and therapy of oral cancer (e.g., magnetic resonance imaging, computed tomography, surgery, and chemoradiotherapy), they still remain far from optimal. Therefore, an urgent need exists for effective and practical techniques of early diagnosis and effective therapy of oral cancer. Currently, various types of nanoparticles have aroused wide public concern, representing a promising tool for diagnostic probes and therapeutic devices. Their inherent physicochemical features, including ultrasmall size, high reactivity, and tunable surface modification, enable them to overcome some of the limitations and achieve the expected diagnostic and therapeutic effect. In this review, we introduce different types of nanoparticles that emerged for the diagnosis and therapy of oral cancers. Then, the challenges and future perspectives for nanoparticles applied in oral cancer diagnosis and therapy are presented. The objective of this review is to help researchers better understand the effect of nanoparticles on oral cancer diagnosis and therapy and may accelerate breakthroughs in this field.

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Section: Gold Nanoparticles For Oral Cancer Diagnosis and Therapymentioning

confidence: 99%

Nanoparticles for Oral Cancer Diagnosis and Therapy

Zheng

Zhou

Yuan

2021

Bioinorganic Chemistry and Applications

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“…Interestingly, the level of hypoxanthine in SERS spectrum was reduced in CRC samples when compared with healthy control, which is consistent with the result of metabolomic profiling . The thymine signal at 741 cm −1 is also found to be generally stronger in the healthy group . The lower levels of hypoxanthine in the circulating blood imply that the highly proliferative nature of CRC cells necessitates large quantities of these molecules for transmission of adenosine triphosphate (ATP) and synthesis of nucleic acids .…”

Section: Resultsmentioning

confidence: 99%

“…The strong bands found at 1141, 1263 and 1484 cm −1 are related to lipids in the blood serum or extracellular vesicles . Lipids found in blood include total cholesterol, high‐density lipoprotein (HDL) cholesterol, low‐density lipoprotein (LDL) cholesterol or triglycerides.…”

Section: Resultsmentioning

confidence: 99%

“…The signal amplification through electromagnetic enhancement, the ability to provide molecule‐specific vibrational data and the inherent swiftness of the optical method make SERS a powerful candidate for the development of sensitive diagnostic strategies . Particularly, in the pursuit of rapid, noninvasive and precise cancer diagnosis, SERS has received an enormous amount of attention in recent years . Different classes of nanostructured metal probes and substrates based on scalable bottom‐up and reproducible top‐down fabrication have been explored for boosting the SERS signal intensities through electric field enhancement via localized surface plasmon resonances (LSPRs).…”

Section: Introductionmentioning

confidence: 99%

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Label‐free diagnosis for colorectal cancer through coffee ring‐assisted surface‐enhanced Raman spectroscopy on blood serum

Yan

Huang

et al. 2020

Journal of Biophotonics

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Surface-enhanced Raman spectroscopy (SERS) is garnering considerable attention for the swift diagnosis of pathogens and abnormal biological status, that is, cancers. In this work, a simple, fast and inexpensive optical sensing platform is developed by the design of SERS sampling and data analysis. The pretreatment of spectral measurement employed gold nanoparticle colloid mixing with the serum from patients with colorectal cancer (CRC). The droplet of particle-serum mixture formed coffee-ring-like region at the rim, providing strong and stable SERS profiles. The obtained spectra from cancer patients and healthy volunteers were analyzed by unsupervised principal component analysis (PCA) and supervised machine learning model, such as support-vector machine (SVM), respectively. The results demonstrate that the SVM model provides the superior performance in the classification of CRC diagnosis compared with PCA. In addition, the values of carcinoembryonic antigen from the blood samples were compiled with the corresponding SERS spectra for SVM calculation, yielding improved prediction results. K E Y W O R D S colorectal cancer diagnosis, label-free detection, machine learning, nanoparticles, SERS

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“…Silver or gold colloids are utilized as SERS substrates more often than nanostructured surfaces, possibly because of the facile synthesis of colloidal NPs and the simplicity of adsorbing biomolecules on metal surface by mixing. Statistical analysis methods such as PCA, PCA-linear discriminate analysis (PCA-LDA), Support Vector Machine (SVM), and SVM in combination with PCA (PCA-SVM) have been employed to develop effective diagnostic algorithms for classification of SERS spectra between normal and cancer patients 164-166 and for classification of patients with different tumor stages 153, 162.…”

Section: Diagnosis Based On Label-free Sers Detection Of Body Fluidsmentioning

confidence: 99%

Recent Progress on Liquid Biopsy Analysis using Surface-Enhanced Raman Spectroscopy

et al. 2019

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Traditional tissue biopsy is limited in understanding heterogeneity and dynamic evolution of tumors. Instead, analyzing circulating cancer markers in various body fluids, commonly referred to as “liquid biopsy”, has recently attracted remarkable interest for their great potential to be applied in non-invasive early cancer screening, tumor progression monitoring and therapy response assessment. Among the various approaches developed for liquid biopsy analysis, surface-enhanced Raman spectroscopy (SERS) has emerged as one of the most powerful techniques based on its high sensitivity, specificity, tremendous spectral multiplexing capacity for simultaneous target detection, as well as its unique capability for obtaining intrinsic fingerprint spectra of biomolecules. In this review, we will first briefly explain the mechanism of SERS, and then introduce recently reported SERS-based techniques for detection of circulating cancer markers including circulating tumor cells, exosomes, circulating tumor DNAs, microRNAs and cancer-related proteins. Cancer diagnosis based on SERS analysis of bulk body fluids will also be included. In the end, we will summarize the “state of the art” technologies of SERS-based platforms and discuss the challenges of translating them into clinical settings.

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Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for tumor stages detection and histologic grades classification of oral squamous cell carcinoma

Cited by 44 publications

References 26 publications

Nanoparticles for Oral Cancer Diagnosis and Therapy

Nanoparticles for Oral Cancer Diagnosis and Therapy

Label‐free diagnosis for colorectal cancer through coffee ring‐assisted surface‐enhanced Raman spectroscopy on blood serum

Recent Progress on Liquid Biopsy Analysis using Surface-Enhanced Raman Spectroscopy

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