A scanning electron microscopy study of the interface between ceramics and bone

Williams, Keith R.; Blayney, A. W.; Frootko, N. J.; Ashton, Brian A.

doi:10.1016/0142-9612(85)90024-9

Cited by 11 publications

(2 citation statements)

References 9 publications

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“…The significance of the adsorption of fractions by the humoral immune system for degradation has not yet been clarified definitively. However, IgA controls processes of resis tance in the mucosa, IgM reacts with the implants on first contact and IgE is released from plasmacytes, chiefly in secondary reactions of immunization [7,10,12,13].…”

Section: Discussionmentioning

confidence: 99%

Immunodiffusion and Immuno-histochemical Investigations on the Reactivity of Oxide Ceramic Middle-Ear Implants

Schadel

Thun

Stork

et al. 1993

ORL

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Oxide ceramic materials (partial and total ossicular replacement prostheses) have been implants of preference for the reconstruction of the ossicular chain because of their excellent biocompatibility. The reaction on the surface of the implants takes place at three biodynamic levels according to the model of Stern’s bilayer. We investigated the adsorption of proteins, which is determined by the cellular reaction and degradation to the surface using radial immunodiffusion and immunohistochemical methods. First, ceramic implants of aluminum oxide, hydroxyapatite, glass ceramic and zirconium oxide have individual actual (i.e. biological) surfaces. With a perthometer and the contact-free laser Focodyn method we determined each actual (i.e. biological) surface of the various ceramic implants mentioned above. Using radial immunodiffusion, the adsorption of albumin, glycoprotein, plasminogen, fibronectin, IgA, IgG and IgM shows characteristic rates of adsorption to the respective ceramic surfaces in correlating to the actual surface. A cross-check with fluorescent antibodies confirmed the protein adsorption. The individual surface adsorption of the proteins remains characteristic and is the basis for the recording of cellular reactions after implantation.

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Section: Discussionmentioning

confidence: 99%

Immunodiffusion and Immuno-histochemical Investigations on the Reactivity of Oxide Ceramic Middle-Ear Implants

Schadel

Thun

Stork

et al. 1993

ORL

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“…Wollastonite has also been used as a biomaterial in the form of sintered ceramic pieces since the 1980´s, e.g. under the name Ceravital [6]. Given the above mentioned indications, that also materials that contain dissolvable silica are resorbable it is proposed to use the more reactive calcium silicate phases as injectable bone void filler.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Mechanical Properties of a Calcium Silicate Based Bone Void Filler

Engqvist

Edlund²,

Gómez-Ortega³

et al. 2006

KEM

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The objective of the paper is to investigate the mechanical and the handling properties of a novel injectable bone void filler based on calcium silicate. The orthopaedic cement based on calcium silicate was compared to a calcium phosphate cement, Norian SRS from Syntes Stratec, with regard to the working (ejection through 14 G needle) and setting time (Gillmore needles), Young’s modulus and the flexural (ASTM F-394) and compressive (ISO 9917) strength after storage in phosphate buffer saline at body temperature for time points from 1h up to 16 weeks. The calcium silicate cement is composed of a calcium silicate powder (grain size below 20 µm) that is mixed with a liquid (water and CaCl2) into a paste using a spatula and a mixing cup. The water to cement ratio used was about 0.5. The calcium silicate had a working time of 15 minutes and a setting time of 17 minutes compared to 5 and 10 minutes respectively for the calcium phosphate cement. The compressive strength was considerably higher for the calcium silicate cement (>100 MPa) compared to the calcium phosphate cement (>40 MPa). Regarding the flexural strength the calcium silicate cement had high values for up to 1 week (> 40 MPa) but it decreased to 25 MPa after 16 weeks. The phosphate cement had a constant flexural strength of about 25 MPa. The results show that calcium silicate cement has the mechanical and handling potential to be used as high strength bone void filler.

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Surface reactions of calcium phosphate ceramics to various solutions

Hyakuna¹,

Yamamuro²,

Kotoura³

et al. 1990

J. Biomed. Mater. Res.

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The surface reactions of calcium phosphate ceramics have been thought to play an important role in bonding with living bone. Hydroxyapatite (HA), tricalcium phosphate (TCP), and two kinds of apatite-containing glass ceramics were immersed in three types of solutions with different chemical constituents. The first solution was a physiological saline, the second contained phosphate (PO4), and the third was a balanced salt solution consisting of calcium (Ca), magnesium (Mg), and PO4. After serial incubation periods, changes in the solutions were assessed by measurement of total Ca, Mg, and PO4. The ceramic surfaces were studied using scanning electron spectroscopy, infrared reflection spectroscopy, and thin-film x-ray diffraction. The surface reactions of the ceramics were greatly affected by the chemical compositions of the surrounding media. In the complete solution with both Ca and PO4, a carbonated apatite layer was formed on the surfaces of HA, TCP, and the glass ceramics. In comparison to HA and TCP, the glass ceramics were characterized as Ca-releasing materials, the dissolved Ca creating an apatite layer on the surfaces in a few days, in conjunction with PO4 stock in the surrounding media. The immersion test with various solutions proved to be a simple and effective method of assessing surface conditions of ceramic materials.

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A scanning electron microscopy study of the interface between ceramics and bone

Cited by 11 publications

References 9 publications

Immunodiffusion and Immuno-histochemical Investigations on the Reactivity of Oxide Ceramic Middle-Ear Implants

Immunodiffusion and Immuno-histochemical Investigations on the Reactivity of Oxide Ceramic Middle-Ear Implants

In Vitro Mechanical Properties of a Calcium Silicate Based Bone Void Filler

Surface reactions of calcium phosphate ceramics to various solutions

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