A rubella serosurvey in postpartum women in the three regions of Peru

Suárez-Ognio, Luis; Adrianzén, Ana; Ortiz, Ana Cecília Tomasini; Martínez, Carlos; Whittembury, Álvaro; Cabezudo, Edwin; Oliveira, Lúcia de; Siqueira, Marilda M.; Castillo‐Solórzano, Carlos

doi:10.1590/s1020-49892007000700005

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…In locations that are weakly coupled to the metapopulation, regular local extinction resulting from the high CCS of rubella [12] will be followed by prolonged periods without re-introduction, which will allow susceptible individuals to leak into older age classes [10]. In agreement with this, a survey of sero-negativity in post-partum women in Peru identified considerable geographical structure, with much higher sero-negativity in the distant forest locations than in the costal region around Lima [30]. Additionally, CRS incidence in hospitals in, for example, Loreto, the weakly coupled province in the northeast of the country, are also high relative to central and coastal locations [31].…”

Section: Discussionmentioning

confidence: 97%

Rubella metapopulation dynamics and importance of spatial coupling to the risk of congenital rubella syndrome in Peru

Metcalf

Munayco

Chowell

et al. 2010

J. R. Soc. Interface.

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Rubella is generally a mild childhood disease, but infection during early pregnancy may cause spontaneous abortion or congenital rubella syndrome (CRS), which may entail a variety of birth defects. Consequently, understanding the age-structured dynamics of this infection has considerable public health value. Vaccination short of the threshold for local elimination of transmission will increase the average age of infection. Accordingly, the classic concern for this infection is the potential for vaccination to increase incidence in individuals of childbearing age. A neglected aspect of rubella dynamics is how age incidence patterns may be moulded by the spatial dynamics inherent to epidemic metapopulations. Here, we use a uniquely detailed dataset from Peru to explore the implications of this for the burden of CRS. Our results show that the risk of CRS may be particularly severe in small remote regions, a prediction at odds with expectations in the endemic situation, and with implications for the outcome of vaccination. This outcome results directly from the metapopulation context: specifically, extinction–re-colonization dynamics are crucial because they allow for significant leakage of susceptible individuals into the older age classes during inter-epidemic periods with the potential to increase CRS risk by as much as fivefold.

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Section: Discussionmentioning

confidence: 97%

Rubella metapopulation dynamics and importance of spatial coupling to the risk of congenital rubella syndrome in Peru

Metcalf

Munayco

Chowell

et al. 2010

J. R. Soc. Interface.

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“…We identified over 220 studies that provided cross‐sectional data and nearly 180 studies that reported on immunity for women of child‐bearing age, primarily for rubella. Table summarizes the over 400 cross‐sectional and women of child‐bearing age measles and rubella serological studies…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Measles and Rubella Serology Studies

Thompson

Odahowski²

2015

Risk Analysis

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Serological tests provide information about individual immunity from historical infection or immunization. Cross-sectional serological studies provide data about the age- and sex-specific immunity levels for individuals in the studied population, and these data can provide a point of comparison for the results of transmission models. In the context of developing an integrated model for measles and rubella transmission, we reviewed the existing measles and rubella literature to identify the results of national serological studies that provided cross-sectional estimates of population immunity at the time of data collection. We systematically searched PubMed, the Science Citation Index, and references we identified from relevant articles published in English. We extracted serological data for comparison to transmission model outputs. For rubella, serological studies of women of child-bearing age provide information about the potential risks of infants born with congenital rubella syndrome. Serological studies also document the loss of maternal antibodies, which occurs at different rates for the different viruses and according to the nature of the induced immunity (i.e., infection or vaccine). The serological evidence remains limited for some areas, with studies from developed countries representing a disproportionate part of the evidence. The collection and review of serological evidence can help program managers identify immunity gaps in the population, which may help them better understand the characteristics of individuals within their populations who may participate in transmission and manage risks.

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Measles and Rubella in the Americas: The Path to Elimination

Siqueira

Brown

2017

Human Virology in Latin America

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A rubella serosurvey in postpartum women in the three regions of Peru

Cited by 7 publications

References 13 publications

Rubella metapopulation dynamics and importance of spatial coupling to the risk of congenital rubella syndrome in Peru

Rubella metapopulation dynamics and importance of spatial coupling to the risk of congenital rubella syndrome in Peru

Systematic Review of Measles and Rubella Serology Studies

Measles and Rubella in the Americas: The Path to Elimination

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