A rolling circle amplification-based DNA machine for miRNA screening coupling catalytic hairpin assembly with DNAzyme formation

Zhuang, Junyang; Lai, Wenqiang; Chen, Guonan; Tang, Dianping

doi:10.1039/c3cc49873e

Cited by 149 publications

(58 citation statements)

References 23 publications

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“…[ 60 ] To avoid the tedious primer design, Tang and coworkers reported a novel RCA module for the sensitive screening of microRNA. [ 41 ] Figure 5e shows the sensing strategy by coupling the RCA module with catalytic hairpin assembly for the formation of a DNAzyme. DNAzyme could acts as the peroxidase mimics to catalyze the TMB/H 2 O 2 to generated signals that were detectable by the ultraviolet (UV)–visible (vis) absorption spectroscopy.…”

Section: Biosensing Applications Based On High‐order Dna‐crnsmentioning

confidence: 99%

DNA‐Based Chemical Reaction Networks for Biosensing Applications

Jiang

Yuan

et al. 2020

Advanced Intelligent Systems

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The nature of biosensing is a biochemical reaction. DNA‐based chemical reaction networks (DNA‐CRNs) as a powerful programming language for describing behaviors of chemical reactions have shown great potential in designs and applications of biosensors. Due to their programmability, modularity, and versatility of the DNA strand, the performance of different detection strategies can be improved mainly by the rational design of DNA‐CRNs. Herein, an overview of the fundamental theory and biosensing processes of DNA‐CRNs is provided. Various detection strategies of DNA‐CRNs are introduced, either in a simple low‐order reaction model or in a complicated high‐order reaction type, in combination with some typical cases for the different detection purposes. In addition, an overview of the recent development of DNA‐CRNs for monitoring the cell microenvironment is presented, which is of significance to uncover some specific cell behaviors and functions. Finally, the roles of DNA‐CRNs in the rational design of high‐performance biosensors are summarized by pointing out the remaining challenges that impede the precise biosensing using DNA‐CRNs in complicated biological environments.

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Section: Biosensing Applications Based On High‐order Dna‐crnsmentioning

confidence: 99%

DNA‐Based Chemical Reaction Networks for Biosensing Applications

Jiang

Yuan

et al. 2020

Advanced Intelligent Systems

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“…194 Another RCA-based DNA machine has been fabricated by coupling miRNA and a catalytic hairpin for the formation of DNAzyme. 195 By integrating strand displacement and nicking enzyme signal amplication into a one-step system, polymerase-nicking enzyme synergetic quadratic DNA machines have been designed to sense Pb 2+ , miRNA and DNA methyltransferase. 196,197 In addition, powered by the hydrolysis of NAD + , a repair ligation-mediated light-producing DNA machine has been universally developed for DNA, thrombin, adenosine, K + and endonuclease detection in human serum.…”

Section: Dna Molecular Machinesmentioning

confidence: 99%

Growing prospects of DNA nanomaterials in novel biomedical applications

et al. 2019

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“… 30 , 31 The catalytic G-quadruplex structure originates from unblocked G-rich single-stranded DNA, the formation of which can be controlled through hybridization and displacement reactions of caged G-rich sequences. 32 , 33 In recent years, some elegant sensing platforms have been successfully developed using G-quadruplex as the signal reporter. 34 – 38 However, there is no trial for the fabrication of a complete set of logic gates, particularly for integrated circuits using caged G-quadruplex as the signal transducer to give out visible results.…”

Section: Introductionmentioning

confidence: 99%