Growing prospects of DNA nanomaterials in novel biomedical applications

Suo, Zhiguang; Chen, Jingqi; Hou, Xialing; Hu, Ziheng; Xing, Feifei; Feng, Lingyan

doi:10.1039/c9ra01261c

Cited by 21 publications

(8 citation statements)

References 217 publications

(176 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, composite polymer materials modified with metal complexes of porphyrins have been widely used in various fields: electrically conductive fibers [1][2][3], fiberoptic sensors [4,5], materials for photonics [6,7], gene therapy [8,9] or biomedicine [10][11][12]. The creation of such composites with controlled functional properties is an actual scientific direction [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)

et al. 2021

View full text Add to dashboard Cite

The creation of innovative fibrous materials based on biodegradable semicrystalline polymers and modifying additives is an urgent scientific problem. In particular, the development of biomedical materials based on molecular complexes and biopolymers with controlled properties is of great interest. The paper suggests an approach to modifying the structure and properties of the composite materials based on poly(3-hydroxybutyrate) (PHB) obtained by the electrospinning method using molecular complexes of hemin. The introduction of 1–5 wt. % of hemin has a significant effect on the supramolecular structure, morphology and properties of PHB-based fibers. Changes in the supramolecular structure intensified with the increasing hemin concentration. On the one hand, a decrease in the fraction of the crystalline phase by 8–10% was observed. At the same time, there is a decrease in the density of the amorphous phase by 15–70%. Moreover, the addition of hemin leads to an improvement in the strength characteristics of the material: the elongation at break increased by 1.5 times, and in the tensile strength, it increased by 3 times. The antimicrobial activity of the hemin-containing composite materials against Escherichia coli and Staphylococcus aureus was confirmed. The obtained materials are proposed to be used in the creation of composite systems for regenerative medicine.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Optical DNA origami sensors are developing into sensitive, rapid, accurate, flexible, and multi-target sensing tools with a low limit of detection (LOD) [18,19,21,[52][53][54][55]. They are used in biology, environment monitoring, and the food safety industry, and have a great potential for applications in biomedicine to detect and monitor diseases and pathogens [56].…”

Section: Dna Origami-based Structures Used For Biomolecular Sensingmentioning

confidence: 99%

DNA Origami as Emerging Technology for the Engineering of Fluorescent and Plasmonic-Based Biosensors

et al. 2020

View full text Add to dashboard Cite

DNA nanotechnology is a powerful and promising tool for the development of nanoscale devices for numerous and diverse applications. One of the greatest potential fields of application for DNA nanotechnology is in biomedicine, in particular biosensing. Thanks to the control over their size, shape, and fabrication, DNA origami represents a unique opportunity to assemble dynamic and complex devices with precise and predictable structural characteristics. Combined with the addressability and flexibility of the chemistry for DNA functionalization, DNA origami allows the precise design of sensors capable of detecting a large range of different targets, encompassing RNA, DNA, proteins, small molecules, or changes in physico-chemical parameters, that could serve as diagnostic tools. Here, we review some recent, salient developments in DNA origami-based sensors centered on optical detection methods (readout) with a special emphasis on the sensitivity, the selectivity, and response time. We also discuss challenges that still need to be addressed before this approach can be translated into robust diagnostic devices for bio-medical applications.

show abstract

“…Relying on various recognition events, biosensors usually function in a similar manner, that the output signal is proportional to the analyte concentration 2 . The sensing performance of biosensors is generally characterized by sensitivity and selectivity, where the sensitivity can be characterized by the dynamic concentration range and limit of detection of analytes while selectivity is evaluated by the influence of various interfering species 3 . Typically, biosensors can provide quantitative information on the presence of analytes 4…”

Section: Introductionmentioning

confidence: 99%

Biosensors based on DNA logic gates

Yin

Wang

Chen

et al. 2020

VIEW

View full text Add to dashboard Cite

Biosensor is a device that responds to a particular target in a selective way by incorporation of biological recognition as sensing unit. For practical biomedical applications, a digital output (a qualitative YES/NO answer) is highly demanded for certain end‐user or point‐of‐care applications. Boolean logic, which can be applied to any type of information expressed as 0 (NO) and 1 (YES), is widely employed to achieve such qualitative analysis. Over the past decade, owing to DNA's advantages of stability, accessibility, and manipulability, significant research efforts have been focused on the design and application of DNA logic gates (DLG)‐based biosensors capable of implementing logic‐gated biomedical functions. This review summarizes the existed representative examples and the advanced developments of DLG biosensors, and discusses the limitations and the future directions on the development of novel nanosensors based on DNA logic operations for realizing highly efficient diagnosis.

show abstract

Growing prospects of DNA nanomaterials in novel biomedical applications

Abstract: Recent progress in DNA-based nanomaterials is summarized, ranging from applications in biosensors, biomedicine/imaging, and molecular logic gates to emerging nanomachines, as well as future perspective discussions.

Cited by 21 publications

References 217 publications

Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)

Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)

DNA Origami as Emerging Technology for the Engineering of Fluorescent and Plasmonic-Based Biosensors

Biosensors based on DNA logic gates

Contact Info

Product

Resources

About