A Revised Structure for the Disialosyl Globo-Series Gangliosides of Human Erythrocytes and Chicken Skeletal Muscle

Inverse expression of Pk and Luke blood group antigens on human RBCs

“…In addition, human RBCs reportedly express one and, possibly two disialo‐globo‐gangliosides related to MSGG(DSGG and DG‐4;Table 1). 39,40 Although preliminary, a LKE‐active glycolipid was identified in the ganglioside fraction of all four LKE‐str+ RBC samples tested. Unfortunately, theamount of RBC ganglioside available from our individual donor samples (1 mL packed RBCs) was insufficient to permit additional studies to elucidate the structure of the LKE‐active glycolipid identified.…”

Sialyl-lactotetra, a Novel Cell Surface Marker of Undifferentiated Human Pluripotent Stem Cells

“…A terminal NeuAc-Hex sequence was indicated by the B 2α ion at m / z 452 and the Y 4α ion at m / z 1517. F , MS 3 of the fragment ion at m / z 1678 gave a series of Y ions, which, together with the B 2α ion and the Y 4α ion in E , allowed identification of a ganglioside with NeuAc-Hex-(NeuAc-)HexNAc-Hex-Hex-Hex sequence, as the disialyl-globopentaosylceramide (40). G , interpretation formulae showing the deduced glycosphingolipid sequences.…”

Human platelets express gangliosides with LKEactivity and ABH blood group activity

“…1) are the major neutral GSL class expressed by RBCs and platelets 14 . In RBCs, two globo‐family gangliosides have also been identified; monosialo‐galactosylgloboside (MSGG, LKE; Table 4) and disialo‐galactosylgloboside 47,61,62 . To determine whether platelets also express globo‐family gangliosides, the platelet ganglioside fraction was immunostained with an LKE MoAb, MC813‐70 (Fig.…”

“…RBCs express GD3 (50‐60% total) and related neolacto‐family gangliosides with sialyl‐i, sialyl‐I, and sialyl‐I/ABH activity 2,66,67 . RBCs also express trace ganglio‐ and globo‐family gangliosides with GM2, LKE, and disialo‐LKE activity, respectively 61,62,67 …”