A Review on Traditional and Pharmacological Uses of Croton bonplandianum with Special Reference to Phytochemical Aspect

Ghosh, Tanmay; Biswas, M. K.; Roy, Pradipta; Guin, Chiranjib

doi:10.9734/ejmp/2018/40697

Cited by 13 publications

(9 citation statements)

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“…It has been found that the AqL and ML extracts of C. bonplandianus possessed antiinflammatory activity which is further confirmed by histopathlogical evaluation of rat paw. Ghosh et al (2018) revealed that the effect of anti-inflammatory action of the extracts of oral Jatropha gossypifolia and C. bonplandianus with diclofenac sodium. It has been observed that C. bonplandianum generally used as a potential anti-inflammatory, anticancer and antimicrobial drug.…”

Section: Discussionmentioning

confidence: 99%

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2021

Pak. J. Pharm. Sci

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Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used for the treatment and prevention of inflammation with the increase in number of side effects. Traditional plants have been used to treat inflammation owing to lesser adverse responses. Croton bonplandianus being an anti-inflammatory plant is extensively utilized all over the world. The methanolic and aqueous leaves extracts of Croton bonplandianus were exposed to anti-inflammatory activity in the carrageenan induced paw edema against standard diclofenac sodium, followed by the histopathlogical examination. The highest dose of methanolic extract were shown significant anti-inflammatory action having a significant P-value (P<0.05-0.001) compared with the diclofenac sodium (P<0.01-0.001) and aqueous extracts (P<0.5-0.01). The histopathological examination illustrated the vasodialation with reduction in the intensity of edema, neutrophils infiltration and other inflammatory cells. C. bonplandianus being a reactive oxygen species scavenger, responsible to exert an excellent anti-inflammatory activity. The present study confirmed the anti-inflammatory potential of drug extracts and authors recommended its utilization in the treatment of pain, inflammation and relevant diseases in future. However, phytochemical screening is to be required for the complete evaluation of active chemical constituent (s).

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Section: Discussionmentioning

confidence: 99%

“…The main constituent regarding the efficacy of C. bonplandianum against inflammation is still not known. (Ghosh et al, 2018). The effect of reactive oxygen species (ROS) may cause severe biological damage and disorders.…”

Section: Discussionmentioning

confidence: 99%

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2021

Pak. J. Pharm. Sci

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“…In 2013, anticancer and antioxidant activities of extracts and pure compounds from several Croton species were reviewed [ 4 ]. Five review articles were published in recent years which focused on ethnopharmacological uses, phytochemistry, and pharmacology of a single Croton species [ 6 , 7 , 8 , 9 , 10 ]. In the last decade, there has been a dramatic progress in the chemical constituents and relevant biological activities of Croton species.…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents from Croton Species and Their Biological Activities

Liu

Liang

2018

Molecules

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The genus Croton belongs to the Euphorbiaceae family, which comprises approximately 1300 species. Many Croton species have been used as folk medicines. This review focuses on the chemical constituents from Croton species and their relevant biological activities, covering the period from 2006 to 2018. A total of 399 new compounds, including 339 diterpenoids, were reported. Diterpenoids are characteristic components of the Croton species. These isolated compounds exhibited a broad spectrum of bioactivities, including cytotoxic, anti-inflammatory, antifungal, acetylcholinesterase inhibitory, and neurite outgrowth-promoting properties. The present review provides a significant clue for further research of the chemical constituents from the Croton species as potential medicines.

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“…phytochemical screening showed the existence of secondary metabolites such as phenolic compounds, tannins, terpenoids, alkaloids, saponins, free anthraquinones, phytosterols, polyphenols and wthanoides . fractionation and characterization approaches on the most biologically active crude extracts led to the isolation of many secondary metabolites from the given medicinal plant [55]. Cyclohexane diepoxides such as crotepoxide, lupeol and betulin, cis-clerodane, crotomacrine, 3β-Acetoxy tetraxer-14-en-28-oic acid, trachylina-19-oic acid, trachylina-18-oic acid are among the isolated compounds from various parts of Croton macrostachyus [56].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antileishmanial Activities of Olea europaea, Kigelia africana, Terminalia mollis, Croton Macrostachyus and Bridella micrantha, Kenyan Medicinal Plants

Wafula

Ayieko

Collins

et al. 2020

IJTDH

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Leishmaniasis is a major public health problem globally. Visceral leishmaniasis is known to be fatal if left untreated, while cutaneous leishmaniasis is the most neglected. The first-line treatment of leishmaniasis is based on pentavalent antimonial drugs which are expensive, requiring inpatient treatment and toxic. The Plants containing active compounds against other protozoan diseases may offer alternatives against leishmania parasites. This study determined the in vitro antileishmanial activity of Olea europaea, Kigelia africana, Terminalia mollis, Croton macrostachyus and Bridella micrantha extracts. The plant samples were dried, pulverized into fine powders and extracted using ethanol at the Center for Traditional Medicine and Drugs Research, KEMRI. The in vitro assays were carried out at the Leishmania laboratory, Centre for Biotechnology Research and Development, KEMRI. In in- vitro assays the inhibitory concentrations (IC50) and Minimum Inhibition Concentration (MIC) on L. major promastigotes, percentage rates of macrophages infected by amastigotes and cytotoxicity on Vero cells were determined. For each parameter analyzed, differences among treatment groups exposed to different drugs were tested by logistic regression. Results showed that promastogote and amastigote growth inhibition was significantly affected by the crude extracts from the plants (P < 0.05) after 24 hours of exposure where the most effective drug was the standard drug (Amphotericin B) while among the crude extracts of the herbal drugs, T. mollis was the most effective against amastigote followed by C. macrostachyus while O. europaea was the least effective. Mammalian cell viability was significantly affected by the various test compounds (P < 0.05) after 24 hours exposure where % cell viability of herbal drugs, B. microstachyus, O. africana resulted to the most toxic effects by reducing the % cell viability to less than 50%. The study recommends the use of T. mollis in management of leishmaniasis in areas they occur. Further analysis of the active compounds that that affect efficacy of the plant extracts is advised.

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A Review on Traditional and Pharmacological Uses of Croton bonplandianum with Special Reference to Phytochemical Aspect

Cited by 13 publications

References 0 publications

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Chemical Constituents from Croton Species and Their Biological Activities

In Vitro Antileishmanial Activities of Olea europaea, Kigelia africana, Terminalia mollis, Croton Macrostachyus and Bridella micrantha, Kenyan Medicinal Plants

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