A review on sign and symptoms of graves's diseases as thyroidal diseases and its treatment with anti thyroidal drug

Bhor, Rohit J.; Damdhar, Harshala; Kokate, Geeta; Salve, Maduri; Andhale, Swati

doi:10.5958/0974-360x.2016.00414.5

Cited by 2 publications

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“…6 But triiodothyronine (T3) is more active than thyroxine (T4). 7 Thyroxine (T4) covers about 90% of the secretion and Ttriiodothyronine(T3) is about 9 % of the secretion from the gland. Reverse T3 (rT3) is the third minor hormone secreted by the thyroid gland that covers 1% of the secretion which is not biologically active.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Hormones in the Human Body: A review

Rajalakshmi¹,

Begam²

2021

J. Drug Delivery Ther.

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Thyroid gland is an essential endocrine gland that is present in the human body. This review highlights the production, regulation and disease conditions of the thyroid hormones. The thyroid gland is controlled with the help of hypothalamus and the pituitary gland that is present in the brain. The production of thyroid hormones involves five main steps such synthesis of thyroglobulin (TG), iodide uptake, iodination of thyroglobulin, storage and release. The two important hormones produced by the thyroid gland are Thyroxine (T4) and Triiodothyronine(T3). These two hormones are iodine containing derivatives. Deficiency of iodine in the body results in the reduction of T3 and T4 production. Excess and deficiency of these two hormones result in the major diseases like Hyper and Hypothyroidism. The synthetic forms of Thyroxine(T4) and Triiodothyronine(T3) used in the Pharmaceutical field are Levothyroxine and Liothyronine. Women are most commonly prone to these thyroid diseases comparatively to men. Undiagnosed disease conditions may become fatal. Levothyroxine therapy is commonly used for thyroidism which is a similar synthetic thyroid hormone. Also natural thyroid hormones that are obtained from the dried thyroid glands of animals are available. Thyroid function test and the measurement of T3, T4 plasma level becomes essential for the identification and regular maintenance of thyroid hormones in the body and human well-being.

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Section: Introductionmentioning

confidence: 99%

Thyroid Hormones in the Human Body: A review

Rajalakshmi¹,

Begam²

2021

J. Drug Delivery Ther.

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Biochemical study on Anti Thyroid Peroxidase Antibody Enzyme in Serum Blood of women with Thyroid Disease

Shaker

Younis

2023

RJPT

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The research involved study the relation between thyroid peroixdase (TPO) and some of the measured biochemical parameters related to the disease (Triiodothyhyronin T3, Thyroxine T4, Thyroid stimulating hormone TSH, glucosee, vitamin D, calcium, uric acid, albumin, alkaline phosphatase enzyme (ALP), transamination enzymes GOT and GPT)in serum blood patients compared with control group, the reasult demonstration is a significant increase in the mean of TPO enzyme (112.63±69.5 Iu/ml), (273.9±235.1 Iu/ml)in hyperthyroidism and hypothyroidism patient respectively compared with mean in control group was ( 33.9 ±18.99 Iu/ml), also the results showed the significant increase in the concentration of T3, glucose, ALP, GOT, GPT enzymes and non significant increase inT4, uric acid, while a significant decrease in TSH, vitamin D, calcium, and non significant decrease with albumin in hyperthyroidism while the results had been shown a significant increase in TSH, glucose, ALP and non-significant increase in uric acid, GOT, GPT enzymes and a significant decrease in T4, vitamin D, calcium, non- significant decrease in T3, albumin in hypothyroidism . Correlation coefficient of TPO enzyme with these clinical parameters showed a negative significant correlation with GPTenzyme in hyperthyroidism and vitamin D, calcium in hypothyroidism while the results showed that there is no significant relationship of TPO enzyme with the rest of boichemical parameters conclusion of this study was that anti-TPO enzyme is diagnosis of autoimmune thyroid disorders and TPO enzyme is plays an important role in making thyroid hormones

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A review on sign and symptoms of graves's diseases as thyroidal diseases and its treatment with anti thyroidal drug

Cited by 2 publications

References 0 publications

Thyroid Hormones in the Human Body: A review

Thyroid Hormones in the Human Body: A review

Biochemical study on Anti Thyroid Peroxidase Antibody Enzyme in Serum Blood of women with Thyroid Disease

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