A Review on Role of Antioxidants in Diabetes

Rajendiran, Deepa; Packirisamy, Subbulakshmi; Giribabu, K.

doi:10.22159/ajpcr.2018.v11i2.23241

Cited by 65 publications

(42 citation statements)

References 36 publications

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“…The level of antioxidant enzymes critically affects the susceptibility of different tissues to oxidative stress and is connected with the development of complications in diabetes (47). Therefore, the usage of antioxidants is considered as one of the strategies used for treat and reduce the complication in diabetic patients (48). In comparison to the synthetic drug, natural plants have lesser toxicity and some are devoid of any side effects.…”

Section: Figure 10 Transmission Electron Micrographs Of a Section Ofmentioning

confidence: 99%

E4An Ultrastructural Study by Transmission Electron Microscope of Exocrine Pancreatic Cells in Diabetic Rats Treated with Herbal Combination

Hadi¹

2019

Baghdad Sci.J

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The current study was designed to investigate the alterations in the ultrastructure of orgenelles and cellular activity of exocrine pancreatic acini of experimentally induced-diabetic rats and to assess the usefulness of herbal combination supplementation in improving the ultrastructure and cellular activity of exocrine pancreas. The number of albino male rats used were 24 which divided into equally 4 groups; group I: control group, group II: alloxan-induced diabetes mellitus (single intraperitoneal dose of alloxan 120 mg/kg for 3 days), group III: herbal combination treatment composed from the extracts of fenugreek seeds (Trigonella foenum-graecum), black cumin (Nigella sativa) seeds, rhizomes of ginger (Zingiber officinale), leaves of olive (Olea europeae), and seeds of ash (Fraxinus ssp). Each rat given 2.5 ml (0.5 ml from each five mixed plant extracts used) for 2 months. group IV: diabetes was induced as group II and treated with herbal combination as group III for 2 months. The processing for investigating by transmission electron microscopy were carried out for all pancreata taken from all groups. There was significant reduction (p<0.05) in mean of FBG levels in diabetic rats treated with herbal combination (group IV) as compared to diabetic control and could revert FBG to normal value compared to negative control The results of examination of semithin and ultrathin sections in diabetic rats revealed many degenerative changes in the exocrine pancreatic tissue in comparison to control group. These degenerative changes can be summarized as disturbances in the arrangement of pancreatic acinar cells and decreased secretory granules in addition to the vacuolation of cytoplasm and pyknotic nuclei were observed in semithin sections. Moreover, degenerated nuclei, vacuolation of cytoplasm, fragmentation of rough endoplasm reticulum and degranulation of the most pancreatic acinar cells were noticed in ultrathin sections. In contrast, the acinar cells of group administrated with herbal combination only had normal ultrastructure, cellular activity, and nuclei, well-developed rough endoplasmic reticulum with abundant zymogen granules. Also, most of the acinar cells retrieved their normal ultrastructure and cellular activity in diabetic group treated with herbal combination and herbal combination could decrease most of the degenerative changes caused by alloxan-induced diabetes. In conclusion, the daily supplementation with this herbal combination to diabetic rat for 2 months could achieving promising effects due to its cytoprotective influence and showed the ability to decreased degenerative damage in the ultrastructure and cellular activity of exocrine pancreatic acini in type 2 diabetic rats.

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Section: Figure 10 Transmission Electron Micrographs Of a Section Ofmentioning

confidence: 99%

E4An Ultrastructural Study by Transmission Electron Microscope of Exocrine Pancreatic Cells in Diabetic Rats Treated with Herbal Combination

Hadi¹

2019

Baghdad Sci.J

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“…Secondary metabolites such as terpenoids that gives plants their odors and others metabolites (quinines and tannins) are responsible for plant flavor and some of the herbs and spices used by humans to season food yield useful medicinal compounds. The phenolic and flavonoid compounds are known as powerful chain-breaking antioxidants for their scavenging ability and which is due to their hydroxyl groups [17][18][19][20][21][22][23][24][25]. The phenolic and flavonoids compounds are the most important groups of plant secondary metabolites.…”

Section: Resultsmentioning

confidence: 99%

Nephroprotective Activity of the Ethnomedicinal Plants Caesalpinia Bonduc and Momordica Dioica From Ne India Against Cisplatin Induced Chemotherapeutic Toxicity

Talukdar

Kalita

Gohain

et al. 2018

Int J Pharm Pharm Sci

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Objective: Cisplatin a potent anticancer drug is used for treatment against different forms of cancer. However a major limitation of cisplatin is its nephrotoxicity and severe side effects. The main objective of the present study was to investigate the nephroprotective activity of the medicinal plants Caesalpinia bonduc and Momordica dioica against cisplatin-induced nephrotoxicity. Methods:In the present study wistar rat models were intraperitoneally injected with cisplatin for eight consecutive days Plant extracts of different compositions were administered for eight days after injection of cisplatin. The polyphenolic content of the crude extracts was investigated using the Folin Ciocalteau method while the flavonoid estimation was carried out using the aluminium chloride method. The antioxidant activities of the extracts were assayed using the DPPH radical scavenging method. Plant extracts were tested for their nephroprotective ability using modified Berthelot method, uricase method, alkaline picrate method. Results:In the present study it was found that the level of creatinine, urea, uric acid and blood urea nitrogen was lowered by the crude hexane extract of Momordica dioica and ethyl acetate extract of Caesalpinia bonduc as compared to the control group. The total phenolic content and the total flavonoid content was found to be highest in the hexane extract of Momordica dioica with 110.51±1.0 μg/GAE and 1.92±0.15 μg/QE. The methanol extract of Caesalpinia bonduc was found to be the highest in inhibition of the DPPH free radicals with nearly 80% inhibition. Conclusion:The present study revealed the nephroprotective ability of the hexane extract of Momordica dioica and ethyl acetate extract Caeselpinia bonduc. The extracts were also found to have higher antioxidant activity and therefore their nephroprotective activity might be due to attenuation of oxidative stress.

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“…On the other hand, the gap between HOMO and LUMO (∆E) is an important index to the inhibition efficiency. ∆E low values indicate good inhibition efficiency [39].…”

Section: Theoretical Studiesmentioning

confidence: 99%

Evaluation of Vicine as a Corrosion Inhibitor for Carbon Steel Alloy

Al-Sawaad¹,

Faili²,

Essa³

2019

Port. Electrochim. Acta

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In the present study, vicine was extracted from sunflower seeds, and has been evaluated as a corrosion inhibitor for carbon steel alloy, at different concentrations and temperatures. Vicine showed maximum inhibiting efficiency of 97%, at 25 ºC. The inhibitor's efficiency was reduced when the temperature increased. Kinetic parameters (Ea, ΔH*, ΔG* and ΔS*) were calculated. The corrosion reaction was suppressed by vicine, because the energy barrier of the corrosion reaction was increased, and it became non-spontaneous, by an endothermic process. Furthermore, ΔHads, ΔGads and ΔSads were also calculated, and showed that the inhibitor was physically adsorbed by a spontaneous and exothermic process. The corrosion was inhibited by simple blocking the reaction sites. The adsorption process obeyed the Langmuir adsorption isotherm. The theoretical and experimental studies depicted that the inhibitor worked by a mixture of physicalchemical adsorption modes.

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A Review on Role of Antioxidants in Diabetes

Cited by 65 publications

References 36 publications

E4An Ultrastructural Study by Transmission Electron Microscope of Exocrine Pancreatic Cells in Diabetic Rats Treated with Herbal Combination

E4An Ultrastructural Study by Transmission Electron Microscope of Exocrine Pancreatic Cells in Diabetic Rats Treated with Herbal Combination

Nephroprotective Activity of the Ethnomedicinal Plants Caesalpinia Bonduc and Momordica Dioica From Ne India Against Cisplatin Induced Chemotherapeutic Toxicity

Evaluation of Vicine as a Corrosion Inhibitor for Carbon Steel Alloy

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