Nephroprotective Activity of the Ethnomedicinal Plants Caesalpinia Bonduc and Momordica Dioica From Ne India Against Cisplatin Induced Chemotherapeutic Toxicity

Talukdar, Anjan Kumar; Kalita, Ranjan; Gohain, Nilakshi; Saikia, Kandarpa Kumar; Kalita, Mohan Chandra

doi:10.22159/ijpps.2018v10i6.23852

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…Various Indian herbals such as Caesalpinia bonduc, Momordica dioica, and Morinda citrifolia have been reported for its renal protective effect against cisplatin [19,20]. VC is being used in Siddha Medicine to recover internal organ damage caused by metals and drugs.…”

Section: Discussionmentioning

confidence: 99%

Vernonia Cinerea (Neichitti Keerai) Regenerates Proximal Tubules in Cisplatininduced Renal Damage in Mice

Amuthan¹,

Devi²,

Shreedhara³

et al. 2019

Asian J Pharm Clin Res

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Objective: The aim of the study was to evaluate whether Vernonia cinerea (VC) regenerates the proximal renal tubular cells in cisplatin-induced necrosis in male Swiss albino mice.Methods: The crude aqueous extract (CAE) of VC was fractionated from non-polar to polar using different solvents. Mice were injected a single dose of cisplatin (15 mg/kg) on day 1, which took 5 days to cause maximal renal damage. From day 6, CAE and all fractions were orally administered (200, 300, and 400 mg/kg) for 5 continuous days. On day 11, blood was collected to estimate urea and creatinine. Kidney was collected for histology and grading was done.Results: Cisplatin induced proximal renal tubular damage (grade 5) in corticomedullary junction, characterized by necrosis, proximal tubular dilatation, inflammation and vasodilation. Aqueous fraction (AF) did not show any regeneration; whereas, 400 mg/kg dose of CAE and butanol fraction (BF) showed a significant reduction (p<0.001) in proximal tubular damage (Grade 3) and 50–75% regeneration of proximal tubular epithelial cells.Conclusion: This is the first study to demonstrate the regenerative potential of Neichitti kashayam (CAE of VC) and its BF in cisplatin-induced proximal tubular damage in kidney. Further study is warranted to find out the dose regimen for complete regeneration, lead compounds, and molecular mechanism.

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Section: Discussionmentioning

confidence: 99%

Vernonia Cinerea (Neichitti Keerai) Regenerates Proximal Tubules in Cisplatininduced Renal Damage in Mice

Amuthan¹,

Devi²,

Shreedhara³

et al. 2019

Asian J Pharm Clin Res

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“…CP is used in the treatment of tumors of the neck, head, ovary, lung, and testicular cancer. The major limitation of CP is its ototoxic and nephrotoxic activity which limits its effectiveness [26]. CP exerts dose-dependent nephrotoxicity which limits its clinical usage in cancer chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective Activity of Asparagus Racemosus Against Cisplatin-Induced Nephrotoxicity and Renal Dysfunction in Experimental Rats

Av¹,

Upasani²

2018

Asian J Pharm Clin Res

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Objective: The current study was designed to evaluate the protective effect of standardized hydroalcoholic extract of Asparagus racemosus (AR) against cisplatin (CP)-induced nephrotoxicity in Wistar rats.Methods: AR extract was administered orally at three dose levels (100, 200, and 400 mg/kg). Vitamin E (250 mg/kg) was used as a standard nephroprotective agent. The kidney function test (estimation of serum creatinine, albumin, and blood urea nitrogen [BUN]), oxidative stress study (estimation of superoxide dismutase and malondialdehyde [MDA] activity), and histological examination of kidneys were conducted.Results: The efficacy of AR was compared with CP-treated group. Serum creatinine and BUN were significantly (p<0.001) elevated in CP-treated group compared to control group. Hydroalcoholic extract of AR (100, 200, and 400 mg/kg) and Vitamin E (250 mg/kg) significantly (p<0.001) decreased the serum creatinine and BUN levels. CP exhibited significant (p<0.001) decrease in albumin when compared to control. Significant (p<0.001) increase in the serum albumin level was found in extract-treated group compared to CP group. Significant (p<0.001) decrease in activity of superoxide dismutase (SOD) was observed in the CP group as compared to control. AR (100 and 200 mg/kg) significantly (p<0.01) increased SOD levels. AR (400 mg/kg) significantly (p<0.001) increased SOD levels. AR (100, 200, and 400 mg/kg) significantly (p<0.001) decreased MDA levels as compared to CP group. Histopathological examination of the kidneys showed that AR markedly ameliorated CP-induced renal tubular necrosis. Extract was found effective at all doses, although high dose (400 mg/kg) was found to be more effective and comparable with standard group (Vitamin E 250 mg/kg). Conclusion:The present investigation revealed that AR resulted in dose-dependent attenuation of CP-induced renal damage in rats.

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“…The animal experiments were performed after acclimatization animals were separated in to four groups of each group with 6 animals was placed in separate cages. [28] Methodology • Group I: After acclimatization of animals, the vehicle was administered orally for 8 days of experimental period. • Group II: Animals were treated with gentamicin with a dose of 80 mg/kg/day for 8 days intraperitoneal.…”

Section: Experimental Designmentioning

confidence: 99%

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Srikanth¹

2019

IJGP

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Objective:The objective of the present study is to develop the pharmacological activity of the herbal drug using ethanolic extract of whole plant of Argyreia nervosa which is claimed for its effective treatment of ailments with low toxicity and economic viability. Collection and authentication of whole plant A. nervosa. Extraction of leaves of A. nervosa with 90% ethanol. Phytochemical screening of ethanolic extract of A. nervosa whole plant. Pharmacological evaluation of ethanolic extract biochemical parameters such as estimation of levels of creatinine in blood serum, estimation of levels of urea in blood serum, estimation of levels of uric acid in blood serum and Statistical analysis. Materials and Methods: Picric acid, alkalin buffer reagent, standard creatinine, surfactant, urea reagent, acid reagent, diaceylmonoxime reagent, urea standard, buffer reagent, enzyme reagent, uric acid standard, A. nervosa, gentamicin, di-ethyl ether. Tests for flavonoids, tests for steroids, tests for alkaloids, tests for tannins, tests for carbohydrates, tests for cardiac glycosides, tests for anthra quinones glycosides, tests for amino acids, test for phenols, acute oral toxicity studies, experimental design: The animal experiments were performed after acclimatization animals were separated in to four groups of each group with 6 animals were placed in separate cages, collection of blood, estimation of serum creatinine, estimation of uric acid, estimation of urea, statistical report. Conclusion: The presence of flavonoids, tannins, steroids, carbohydrates, phenols etc. In acute toxicity studies the test dose 200 mg/kg and 400 mg/ kg was chosen as experimental doses. Nephroprotective activity of ethanolic extract of A. nervosa was screened for biochemical parameters (serum creatinine, serum uric acid, serum urea). The ethanolic extracts have produced effective nephroprotective action as evident by results obtained from the studies. The interpretation of the results was done after subjecting the data obtained from various studies by simple graph. The studies indicate that ethanolic extract of A. nervosa whole plant producing promising results in treatment of nephrotoxicity

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Nephroprotective Activity of the Ethnomedicinal Plants Caesalpinia Bonduc and Momordica Dioica From Ne India Against Cisplatin Induced Chemotherapeutic Toxicity

Cited by 5 publications

References 18 publications

Vernonia Cinerea (Neichitti Keerai) Regenerates Proximal Tubules in Cisplatininduced Renal Damage in Mice

Vernonia Cinerea (Neichitti Keerai) Regenerates Proximal Tubules in Cisplatininduced Renal Damage in Mice

Nephroprotective Activity of Asparagus Racemosus Against Cisplatin-Induced Nephrotoxicity and Renal Dysfunction in Experimental Rats

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