A review on infection with Chlamydia trachomatis

Manavi, K

doi:10.1016/j.bpobgyn.2006.06.003

Cited by 149 publications

(127 citation statements)

References 27 publications

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“…Chlamydia trachomatis (CT) is an important human pathogen that causes various diseases and syndromes, including urogenital infection, trachoma and lymphogranuloma venereum, depending on the serovar involved [1]. As an agent of urogenital infection, C. trachomatis is the most prevalent bacterial sexually transmitted disease (STD), with estimated 92 million new cases annually worldwide [2].…”

Section: Introductionmentioning

confidence: 99%

Genotyping and prevalence of Chlamydia trachomatis infection among women in Belém, Pará, northern Brazil

Brasiliense

Borges

Ferreira

2016

J Infect Dev Ctries

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Introduction: Genital Chlamydia trachomatis infection is one of the most prevalent sexually transmitted diseases in women, and undetected cases of the disease are highly associated with long-term complications. Despite the high prevalence of infections in Brazil, very little is known about the distribution of C. trachomatis genovars. In this study, we determined the prevalence and genotypes of C. trachomatis in women treated at a public hospital in the Brazilian city of Belém, the capital of the state of Pará. Methodology: A total of 154 women were tested for chlamydial infection by PCR using specific primers for the C. trachomatis cryptic plasmid. Genotyping of positive samples was performed by sequencing the ompA gene and conducting further phylogenetic analysis. Results: Out of the 154 samples, 17 were found to be positive using C. trachomatis cryptic plasmid PCR. The overall prevalence of C. trachomatis infection was 11%, with the highest prevalence observed in women between 16 and 20 years of age. Five genotypes were found to be associated with endocervical infection. Genotype F was most frequently found (37.5%), followed by genotypes J (25%), E (25%), I (6.25%), and D (6.25%). Conclusions: This study emphasizes the relevance of C. trachomatis infection in the young female population of the Brazilian Amazon region. It also demonstrates the diversity of genotypes involved in genital infection in this population.

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Section: Introductionmentioning

confidence: 99%

Genotyping and prevalence of Chlamydia trachomatis infection among women in Belém, Pará, northern Brazil

Brasiliense

Borges

Ferreira

2016

J Infect Dev Ctries

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“…Chlamydia trachomatis is the commonest sexually transmitted bacterial infection in the world [1,2]. In women, up to 80% of C. trachomatis infection is asymptomatic; thus few infected women seek medical care, resulting in continued transmission to sexual partners [1].…”

Section: Introductionmentioning

confidence: 99%

Comparison of four serological assays for the diagnosis of Chlamydia trachomatis in subfertile women

Muvunyi

Claeys

Sutter

et al. 2011

J Infect Dev Ctries

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Introduction: Chlamydia antibody testing (CAT) in serum has been introduced as a screening method in the infertility workup. We evaluated the test characteristics of two ELISA tests compared to micro-immunofluorescence tests (MIFs). MIFs are considered the gold standard in the C. trachomatis IgG antibodies detection. We also compared the accuracy of all CAT tests in predicting tubal subfertility, using laparoscopy as a reference. Methodology: Four commercial serological methods were used to analyse 101 serum samples for the presence of C. trachomatis IgG antibodies from patients at the Infertility Clinic of Ghent University Hospital. The diagnostic utility for prediction of tubal infertility of serological methods was evaluated based on patients' medical records. Results: A comparison of the serological assays showed little difference in the major performance characteristics: the sensitivities of all MIFs and ELISAs were 100% for all assays (except the ELISA Vircell, with a sensitivity of 90%), and the specificities ranged from 92% for MIF Ani Labsystems to 98% for the MIF Focus and ELISA Vircell. As compared to laparoscopy data, CAT positivity in subfertile women with tubal damage (n=40) did not significantly differ from that of subfertile women without tubal damage (n=61): Positive predictive values (PPV) of CAT ranged from 53% to 60% and negative predictive values (NPV) ranged from 62% to 64%. Conclusion: evaluated ELISAs are comparable to MIFs in the detection of C. trachomatis IgG antibodies and should be preferred for large serological studies, especially in resource poor settings.

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“…trachomatis other to cause chronic, clinically unapparent infections of the upper genital tract that may result in significant damage to the reproductive organs [49], can cause cervical dysplasia and cancer [50] including ovarian cancer [51] and can also lead to vulvar carcinogenesis [52]. Importantly, C. trachomatis has been shown to be fully viable and metabolically active in both the acute and chronic, persistent infection.…”

Section: Chlamydiae Spp and Their Role In Chronic Diseases And In Camentioning

confidence: 99%

Role of Chlamydia in the Development of Ocular Adnexal Lymphoma

Contini¹,

Seraceni²,

Maritati³

et al. 2013

JCT

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The aetiology of OAL is undefined, although much attention has been recently focused on determining whether OAL is caused by an autoimmune disorder, chronic antigenic stimulation or both. It is becoming evident that infectious agents underlying chronic eye infection, as Chlamydia, may play a role in ocular lymphomagenesis. The high prevalence of Chlamydophila psittaci in patients with OAL has suggested a potential oncogenic role for its tendency to cause chronic and persistent infections, although it has been documented an evident geographical variability and response to antibiotic treatment. For C. pneumoniae, the findings so far obtained are very limited not only for identification in OAL but also for the specific treatment with antibiotics. The recent molecular and cultural evidence of C. trachomatis in patients with OAL, seems to suggest that also this pathogen may contribute to pathogenesis of such lymphoma. The potential application of bacteria-eradicating therapy at local and systemic level may ultimately result in safer and more efficient therapeutic option for patients affected by these malignancies. Moreover, a close collaboration between experts in ophthalmology, infectious diseases and hematology will help, in the future, to effectively manage this disease. This review attempts to weigh the currently available evidence regarding the role that Chlamydia play in development of OAL and focuses on patients with OAL observed at our Institution.

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A review on infection with Chlamydia trachomatis

Cited by 149 publications

References 27 publications

Genotyping and prevalence of Chlamydia trachomatis infection among women in Belém, Pará, northern Brazil

Genotyping and prevalence of Chlamydia trachomatis infection among women in Belém, Pará, northern Brazil

Comparison of four serological assays for the diagnosis of Chlamydia trachomatis in subfertile women

Role of Chlamydia in the Development of Ocular Adnexal Lymphoma

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