A review on hyperthermia via nanoparticle-mediated therapy

Sohail, Ayesha; Ahmad, Zaki; Bég, O. Anwar; Arshad, Sarmad; Sherin, Lubna

doi:10.1016/j.bulcan.2017.02.003

Cited by 93 publications

(51 citation statements)

References 60 publications

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“…In addition, they possess a unique surface, which is able to carry targeting molecules for cancer cells and go deeply into tumor tissues. 62 Furthermore, Fe 3 O 4 NPs have been proved useful for cancer treatment due to their magnetic hyperthermia in which induced high temperatures were achieved and controlled by alternating magnetic field (AFM). 63 The generated heat is sufficient to destroy cancerous cells but may affect healthy tissues.…”

Section: Iron Oxide (Fe 3 O 4 ) Npsmentioning

confidence: 99%

Recent advances in functional nanostructures as cancer photothermal therapy

Hussein¹,

Zagho²,

Nasrallah³

et al. 2018

IJN

118

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Being a non-invasive and relatively safe technique, photothermal therapy has attracted a lot of interest in the cancer treatment field. Recently, nanostructure technology has entered the forefront of cancer therapy owing to its ability to absorb near-infrared radiation as well as efficient light to heat conversion. In this study, key nanostructures for cancer therapy including gold nanoparticles, magnetite iron oxide nanoparticles, organic nanomaterials, and novel two-dimensional nanoagents such as MXenes are discussed. Furthermore, we briefly discuss the characteristics of the nanostructures of these photothermal nanomaterial agents, while focusing on how nanostructures hold potential as cancer therapies. Finally, this review offers promising insight into new cancer therapy approaches, particularly in vivo and in vitro cancer treatments.

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Section: Iron Oxide (Fe 3 O 4 ) Npsmentioning

confidence: 99%

Recent advances in functional nanostructures as cancer photothermal therapy

Hussein¹,

Zagho²,

Nasrallah³

et al. 2018

IJN

118

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“…For each fixed frequency of ultrasound in the considered spectral range (3)(4)(5)(6)(7)(8), the mean attenuation values revealed for MNP8 and MNP16 were significantly different from the attenuation values for MMP8 and MMP16, respectively. More specifically, testing the difference between the average attenuation measured in MNP8 and MMP8 yielded a P<0.001 for all frequencies considered.…”

Section: E Statistical Analysis Resultsmentioning

confidence: 76%

“…Comparing samples of MNP16 and MMP16, P < 0.001 and P < 0.05 were obtained for the 3.5-8 and 3-3.49 MHz frequency bands, respectively. The two-sample test was also applied to the mean BSC values determined for each fixed ultrasonic frequency in the considered spectral range (3)(4)(5)(6)(7)(8). The results provided that the materials of the MNP8 and MNP16 samples differed statistically significantly from the corresponding materials of the MMP8 and MMP16 samples (P < 0.001).…”

Section: E Statistical Analysis Resultsmentioning

confidence: 99%

Ultrasound assessment of the conversion of sound energy into heat in tissue phantoms enriched with magnetic micro‐ and nanoparticles

et al. 2019

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Purpose Nowadays, the improvement of ultrasonic hyperthermia therapy is often achieved by adding hard particles to the sonicated medium in order to increase the heating efficiency. The explanation of the phenomenon of ultrasonic heating still requires testing on tissue mimicking materials (TMMs), enriched with particles of different sizes and physical properties. Our goal was to determine, by comparing their quantitative acoustic properties, which TMMs, with magnetic micro‐ or nanoparticles, convert more ultrasonic energy into heat or which of the particles embedded in the agar gel act as more effective thermal sonosensitizers. Methods We manufactured a pure agar gel and an agar gel with the addition of magnetic micro‐ or nanoparticles in two proportions of 8 and 16 mg/ml. Ultrasound quantitative techniques, the broadband reflection substitution technique and backscattered spectrum analysis were used to characterize the samples by speed of sound (SOS), frequency‐dependent attenuation, and backscattering coefficients. The integrated backscattering coefficients were also calculated. The quantitative parameters, scattering, and attenuation coefficients of ultrasound in phantoms with micro‐ and nanoparticles were estimated. Based on the attenuation and scattering of ultrasound in the samples, the ultrasonic energy absorption, which determines the heating efficiency, was evaluated. Additionally, the temperature increase during sonication of the phantoms by an ultrasonic beam was directly measured using thermocouples. Results The density of the materials with nanoparticles was higher than for the materials with microparticles with the same fractions of particles. The SOS for all materials ranged from 1489 to 1499 m/s. The attenuation in the whole frequency range (3–8 MHz) was higher for the materials with nanoparticles than for the materials with microparticles. For the materials with the lower content (8 mg/ml) of particles, the attenuation coefficient was 0.2 dB/(MHz cm). For the 16 mg/ml concentration of nanoparticles and microparticles, the attenuation coefficients were 0.66 and 0.45 dB/(MHz cm), respectively. The value of backscattering coefficient in the whole frequency range was greater for the materials with microparticles than for the materials with nanoparticles. The values of the integrated backscattering coefficient were 0.05 and 0.08 1/m for the materials with nanoparticles and 0.46 and 0.82 1/m for the materials with microparticles and concentrations of 8 and 16 mg/ml, respectively. The rates of temperature increase in the first 3 s due to ultrasonic heating were higher for the materials with nanoparticles than for the materials with microparticles. Conclusions Based on acoustical measurements, we confirmed that all materials can be used as tissue phantoms in the study of ultrasonic hyperthermia, as their properties were in the range of soft tissue properties. We found that the nanoparticle‐doped materials had greater attenuation and smaller scattering of ultrasound than the materials with microparticles,...

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“…arrangement of magnetic dipole moments due to Brownian and Neel relaxation. [286][287][288] Of these, single domain particles consisting of an iron oxide core and organic or inorganic surface, also known superparamagnetic nanoparticles (SPIONs), are of particular interest. SPIONs can be heated and guided to a specific direction in the presence of an external magnetic field while maintaining their colloidal stability, which contributes to a uniform heating effect on cancer tissues.…”

Section: Chemo-thermal Combination Therapiesmentioning

confidence: 99%

Nanoparticles‐Mediated Combination Therapies for Cancer Treatment

Shrestha

Tang

Romero

2019

Advanced Therapeutics

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Cancer is a dynamic disease characterized by its heterogeneous nature. This heterogeneity results in critical problems that interfere with the eradication of cancer tumors such as multidrug resistance, drug efflux capacity, narrow therapeutic window, and undesired side effects. Nanomedicine has introduced new platforms for drug delivery to enhance therapeutic efficiency of anticancer drugs. In addition to drug delivery, nanocarriers such as liposomes, carbon nanotubes, quantum dots, polymeric nanoparticles, dendrimers, and metallic nanoparticles can be designed for detection, diagnosis, and treatment. Recent studies support the idea that a combination of two or more nanoparticle-mediated therapies can result in a synergistic therapeutic outcome to improve current cancer treatments. In this progress report, recent advances in nanoparticles-based combination therapies are discussed. A brief overview of the complexity of cancer tumor's microenvironment is presented, followed by discussion of combinatorial therapies categorized based on chemotherapeutic agents, nucleic acid or therapeutic proteins, energy-based therapies and imaging techniques for theranostic application. Different nanotechnological platforms are developed for combination therapy as tools with a great potential to tackle the most critical issues of current cancer treatments. A deeper understanding of these nanotechnologies and their possible long-term effects in biological systems is needed for further clinical translation.

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A review on hyperthermia via nanoparticle-mediated therapy

Cited by 93 publications

References 60 publications

Recent advances in functional nanostructures as cancer photothermal therapy

Recent advances in functional nanostructures as cancer photothermal therapy

Ultrasound assessment of the conversion of sound energy into heat in tissue phantoms enriched with magnetic micro‐ and nanoparticles

Nanoparticles‐Mediated Combination Therapies for Cancer Treatment

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