A Review on Extended Release Matrix Tablet

Abstract

The aim of the study was to explore the necessity, advantages and different techniques of extended release matrix tablet to achieve continuous delivery of drugs at predictable rate and reproducible kinetics for a preterm delivery and provide a therapeutic amount of a drug to the proper site of the body to achieve promptly and then maintain the desired drug concentration. Different types of extended release matrix tablet have been explained briefly along with the various formulation which mainly by wet granulation or direct compression method or by dispersion of solid particle within a porous matrix formed by using different polymers like HPMC, guar gum, xanthan gum, pectin, chitosan etc. The matrix controls the release rate of drug. Release retardants like HPMC can aid in extended release and thus they form core excipient of the formulation. The matrices used may be hydrophilic, hydrophobic, mineral, or biodegradable types. The drug release rate can be studied by in vitro dissolution studies. Some drugs that have been formulated as extended release matrix tablets are Ambroxol HCl, Clarithromycin, Indomethacin etc. The extended release matrix tablets can assure better patient compliance through reduction in total dose and dosage regimen, which can be great help to treat chronic diseases. This review highlights the types of matrices, mechanisms involved and evaluation studies.

The Role of Matrix Tablet in Oral Drug Delivery System

“…The addition of surfactant to the formulation can be also influenced both the drug release and proportion of the total drug that can being corporate into a matrix. [5,6] Biodegradable matrix system:…”

“…Constant rate drug delivery always has been one of the primary target of controlled release system for the drug with narrow therapeutic index. [5,6] Hydrophilic matrix system:…”

“…They having swelling properties and allows to rapid formulation of an external gel layer, which play important role in controlled drug release. [5,6] Figure: 1. Possible drug release mechanism from various matrix system.…”

Recent Patents on Modified Release Oral Dosage Forms

“…Advantages of Modified/Extended/Delayed release systems: 3,5  Reduced dosing frequency  Improved patient compliance  Reduction in the fluctuation in plasma drug levels  Reduction in gastrointestinal tract irritation and related side effects  Dose reduction  Suitable for drugs having elimination half-life between 2 to 8 hours Shortcomings of Modified/Extended/Delayed release systems: 3,5  Not cost effective  Does not allow prompt changes in drug dosage as needed during therapy  Less flexible dosage regimens  Does not consider disease and patient specific drug deposition variation  Not suitable for drugs having short biologic half life  Not suitable for drugs which require higher doses  Not suitable for drugs having narrow therapeutic index Modified release drug delivery systems thus aid in achieving a therapeutically effective steady state for prolonged period of time. Hence, this review article provides an overview of recent patents pertaining to the modified release drug delivery systems with specific focus on oral dosage forms and its formulation strategies.…”

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“…It is widely used as an expectorant and a mucolytic agent used in the treatment of respiratory disorders such as chronic bronchitis and bronchial asthma. Ambroxol hydrochloride is capable of inducing thin copious bronchial secretion 6 . It depolymerizes mucopolysaccharides directly as well as by liberating lysosomal enzymes network of fibers in tenacious sputum is broken 7 .…”