A review on development of bio-active thiosemicarbazide derivatives: Recent advances

Acharya, Prachi T.; Bhavsar, Zeel A.; Jethava, Divya J.; Patel, Dhaval B.; Patel, Hitesh D.

doi:10.1016/j.molstruc.2020.129268

Cited by 78 publications

(62 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Substituted thiosemicarbazides (TSCs) constitute an important class of organic compounds with the general formula R-(C O)-NH-NH-(C S)-R 0 and find application in the synthesis of five-and six-membered heterocyclic compounds (Gazieva & Kravchenko, 2012) and transition-metal complexes (Campbell, 1975). The chemical diversity of thiosemicarbazides, and their synthesis, including their role in biological applications, is nicely summarized in a recent review article (Acharya et al, 2021). Dibenzoylated TSCs have been synthesized and explored for their antibacterial activity (Qandil et al, 2006).…”

Section: Chemical Contextmentioning

confidence: 99%

Structural investigation of N-[2-(4-fluoro-3-phenoxybenzoyl)hydrazinecarbothioyl]benzamide and N-[2-(4-fluoro-3-phenoxybenzoyl)hydrazinecarbothioyl]-4-methoxybenzamide

Dey¹,

Shruti²,

Chopra³

et al. 2021

Acta Cryst E

View full text Add to dashboard Cite

The compound N-[2-(4-fluoro-3-phenoxybenzoyl)hydrazinecarbothioyl]benzamide, C21H16FN3O3S, crystallizes in the monoclinic centrosymmetric space group P21/c and its molecular conformation is stabilized via an intramolecular N—H...O hydrogen bond. The corresponding para-methoxy derivative, namely, N-[2-(4-fluoro-3-phenoxybenzoyl)hydrazinecarbothioyl]-4-methoxybenzamide, C22H18FN3O4S, crystallizes in the monoclinic centrosymmetric space group C2/c. The supramolecular network mainly comprises N—H...O, N—H...S and C—H...O hydrogen bonds, which contribute towards the formation of the crystal structures for the two molecules. The different intermolecular interactions have been further analysed using Hirshfeld surface analysis and fingerprint plots.

show abstract

Section: Chemical Contextmentioning

confidence: 99%

Structural investigation of N-[2-(4-fluoro-3-phenoxybenzoyl)hydrazinecarbothioyl]benzamide and N-[2-(4-fluoro-3-phenoxybenzoyl)hydrazinecarbothioyl]-4-methoxybenzamide

Dey¹,

Shruti²,

Chopra³

et al. 2021

Acta Cryst E

View full text Add to dashboard Cite

show abstract

“…Nitrogen-, oxygen- and sulfur-based heterocyclic compounds are contributing extensively in the current medicinal chemistry because of their wide applications in drug discovery and development [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. As the potentially privileged scaffolds, pyridine-fused heterocycles have attracted attention due to their effective and widespread biological properties for the treatment of different diseases such as cancer, diabetes, hyperpigmentation, tuberculosis, hyperplasia and ulcer [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Pyridine Scaffolds, Phenols and Derivatives of Azo Moiety: Current Therapeutic Perspectives

et al. 2021

View full text Add to dashboard Cite

Synthetic heterocyclic compounds have incredible potential against different diseases; pyridines, phenolic compounds and the derivatives of azo moiety have shown excellent antimicrobial, antiviral, antidiabetic, anti-melanogenic, anti-ulcer, anticancer, anti-mycobacterial, anti-inflammatory, DNA binding and chemosensing activities. In the present review, the above-mentioned activities of the nitrogen-containing heterocyclic compounds (pyridines), hydroxyl (phenols) and azo derivatives are discussed with reference to the minimum inhibitory concentration and structure–activity relationship, which clearly indicate that the presence of nitrogen in the phenyl ring; in addition, the hydroxyl substituent and the incorporation of a diazo group is crucial for the improved efficacies of the compounds in probing different diseases. The comparison was made with the reported drugs and new synthetic derivatives that showed recent therapeutic perspectives made in the last five years.

show abstract

“…The introduction of the thione group, either in 3- or 5-position, leads to an enhancement of biological activities related to triazole moiety [ 70 ]. The triazolethione system is a cyclic analog of very important components (such as thiosemicarbazides) that have effective biological applications [ 71 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Activity of New Azole, Diazole and Triazole Derivatives Based on p-Aminobenzoic Acid

Sapijanskaitė-Banevič

Palskys

Vaickelionienė

et al. 2021

Molecules

View full text Add to dashboard Cite

The p-aminobenzoic acid was applied for the synthesis of substituted 1-phenyl-5-oxopyrrolidine derivatives containing benzimidazole, azole, oxadiazole, triazole, dihydrazone, and dithiosemicarbazide moieties in the structure. All the obtained compounds were evaluated for their in vitro antimicrobial activity against Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Salmonella enteritidis, Escherichia coli, and Pseudomonas aeruginosa by using MIC and MBC assays. This study showed a good bactericidal activity of γ-amino acid and benzimidazoles derivatives. The antimicrobial activity of the most promising compounds was higher than ampicillin. Furthermore, two benzimidazoles demonstrated good antimicrobial activity against L. monocytogenes (MIC 15.62 µg/mL) that was four times more potent than ampicillin (MIC 65 µg/mL). Further studies are needed to better understand the mechanism of the antimicrobial activity as well as to generate antimicrobial compounds based on the 1-phenyl-5-oxopyrrolidine scaffold.

show abstract

A review on development of bio-active thiosemicarbazide derivatives: Recent advances

Cited by 78 publications

References 102 publications

Structural investigation of N-[2-(4-fluoro-3-phenoxybenzoyl)hydrazinecarbothioyl]benzamide and N-[2-(4-fluoro-3-phenoxybenzoyl)hydrazinecarbothioyl]-4-methoxybenzamide

Structural investigation of N-[2-(4-fluoro-3-phenoxybenzoyl)hydrazinecarbothioyl]benzamide and N-[2-(4-fluoro-3-phenoxybenzoyl)hydrazinecarbothioyl]-4-methoxybenzamide

Pyridine Scaffolds, Phenols and Derivatives of Azo Moiety: Current Therapeutic Perspectives

Synthesis and Antibacterial Activity of New Azole, Diazole and Triazole Derivatives Based on p-Aminobenzoic Acid

Contact Info

Product

Resources

About