A review on cubosome: The novel drug delivery system

Abstract

Cubosomes are nanoparticles in structure which is mainly made of certain amphiphilic lipids in definite proportion, known as bicontinuous cubic phase liquid crystals. Hydrating a surfactant or polar lipid that forms cubic phase and then dispersing a solid like phase into smaller particles usually forms a cubosomes. They perform solid like rheology with unique properties of practical interest. They are thermodynamically stable and they have carvenous (honeycomb) structures which are tightly packed twisted into three dimensional bilayers. This type of complex structure allows them to have greater drug loading ability. Cubosomes have ability to encapsulate the hydrophobic, hydrophilic, amphiphilic substances. Cubosomes can increase the solubility of poorly soluble drug. Cubosome dispersions are bioadhesive and biocompatible. Because of their properties, cubosome are versatile systems, administrable by different ways such as orally, percutaneously and parenterally. Cubosome structure by means of electron microscopy, light scattering, x-ray and NMR, nevertheless few researchers has been studying the potential of cubosome as delivery systems.

Trends in Cosmeceuticals Based Nanotechnology: Up-to-Date

“…Dendrimers are incorporated in the formulation of many cosmetics. L'Oreal owns a patent on the use of dendrimers in cosmetics like mascara and nail polish [20].…”

“…A bi-continuous cubic liquid crystalline compound with discrete and sub-micron size nanoformulations, called as Cubosomes. However, they are self-assembled liquid crystalline particles with a solid like rheology that have unique features of practical significance [20] wherein lipophilic, amphiphilic, and watersoluble cosmetic compound can be incorporated. For cosmetic formulations, this system may be used as challenging techniques [21].…”

“…A common application for such novel material is as drug delivery vehicle. Cubosomes particles are being studied in collaboration with cosmetic business such as L'Oréal and NIVEA to see if they can be used as oil in water emulsion stabilisers and pollutant absorbent in cosmetics [20]. Researchers in cosmetic science have been drawn to cubosomes because of their ability to solve problems associated with dermal delivery system.…”

Preclinical assessment of nanostructured liquid crystalline particles for the management of bacterial keratitis: in vivo and pharmacokinetics study

“…Cubic crystalline structure promotes high drug entrapment as they have higher portion of lipid that presents large surface area. Entrapment e ciency was determined by the concentration of glyceryl monooleate and poloxamer [50]. The outcome indicated that with the increase in concentration of lipid and surfactant, the entrapment was also increased.…”

Review on Cubosomes

“…5. This method cannot avoid the forming of vesicles through cryo-TEM, many vesicle sized-like structures are also observed to be coexist with cubosomes [23][24][25][26][27][28][29]. In the preparation of drug-containing vesicles used by freeze-drying technique.…”