A Review on Cancer Stem Cells in Vasculogenic Mimicry Formation: A New Dimension for Targeted Therapy

Murugesan, Ambika; Balakrishnan, Sadhishkumar; Saranyan, R.; Manivannan, Elangovan; Rajmohan, M.

doi:10.1177/2320206820960862

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…Additionally, preclinical pharmacological studies have shown that VM is connected to anticancer therapy resistance [83]. A significant amount of data suggests that CSCs aid in the development of VM (Figure 1H) [84]. The VM phenotype of tumour cells has a molecular signature that includes upregulated expression of genes related to embryonic progenitors, endothelial cells, vessel formation, matrix remodelling, and coagulation inhibitors, as well as downregulated expression of genes primarily related to lineage-specific phenotype markers [80,85].…”

Section: Vasculogenic Mimicrymentioning

confidence: 99%

Microbiota-Derived Natural Products Targeting Cancer Stem Cells: Inside the Gut Pharma Factory

Artusa

Calabrone

Mortara

et al. 2023

IJMS

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Cancer stem cells (CSCs) have drawn much attention as important tumour-initiating cells that may also be crucial for recurrence after chemotherapy. Although the activity of CSCs in various forms of cancer is complex and yet to be fully elucidated, opportunities for therapies targeting CSCs exist. CSCs are molecularly distinct from bulk tumour cells, so they can be targeted by exploiting their signature molecular pathways. Inhibiting stemness has the potential to reduce the risk posed by CSCs by limiting or eliminating their capacity for tumorigenesis, proliferation, metastasis, and recurrence. Here, we briefly described the role of CSCs in tumour biology, the mechanisms involved in CSC therapy resistance, and the role of the gut microbiota in cancer development and treatment, to then review and discuss the current advances in the discovery of microbiota-derived natural compounds targeting CSCs. Collectively, our overview suggests that dietary intervention, toward the production of those identified microbial metabolites capable of suppressing CSC properties, is a promising approach to support standard chemotherapy.

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Section: Vasculogenic Mimicrymentioning

confidence: 99%

Microbiota-Derived Natural Products Targeting Cancer Stem Cells: Inside the Gut Pharma Factory

Artusa

Calabrone

Mortara

et al. 2023

IJMS

View full text Add to dashboard Cite

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Expression of HIF-1α and Nestin in oral squamous cell carcinoma and its association with vasculogenic mimicry

Murugesan,

Bharath,

Balakrishnan

et al. 2023

Journal of Cancer Research and Therapeutics

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Oral cancer is a common cause of morbidity and mortality with poor prognosis in head and neck carcinomas. The cancer is a complex structure, where 50%–60% of solid tumors exhibit areas of hypoxia which is influenced by the transcriptional activity of hypoxia-inducible factor (HIF). HIF promotes stemness and proliferation of vessel-like structures tumors which are responsible for invasion and metastasis. Aim: To evaluate and correlate the expression of HIF1-α and Nestin in tumor center and periphery of nonmetastatic, and recurrent oral squamous cell carcinoma (OSCC) and its association with vasculogenic mimicry. Materials and Methods: About 60 histopathological proven cases of OSCC with proper tumor center and periphery were collected. Among them 25 are nonmetastatic, 25 metastatic, and 10 recurrent cases of OSCC. Immunohistochemical analysis of HIF, Nestin, and CD31/PAS (periodic acid Schiff) was done. Results: Based on the extent of tumor cells stained, staining intensity and index score, expression of both HIF and Nestin was highly significant in periphery of metastatic OSCC with a P value of 0.003* and 0.001*. The total number of vessels expressed in nonmetastatic, metastatic, and recurrent OSCC was not significant but the overall expression of CD31/PAS was significant in the periphery of the tumor with a P value of 0.024*. Correlating the overall expression, HIF showed a positive relation with Nestin and CD31/PAS with a P value of 0.026* and 0.038* in nonmetastatic OSCC using Pearson’s correlation coefficient analysis. Conclusion: Based on the above results hypoxia plays a vital role in cancer stem cells maintenance with the formation of vessel-like structures by tumor cells at an early stage of cancer development.

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A Review on Cancer Stem Cells in Vasculogenic Mimicry Formation: A New Dimension for Targeted Therapy

Cited by 2 publications

References 44 publications

Microbiota-Derived Natural Products Targeting Cancer Stem Cells: Inside the Gut Pharma Factory

Microbiota-Derived Natural Products Targeting Cancer Stem Cells: Inside the Gut Pharma Factory

Expression of HIF-1α and Nestin in oral squamous cell carcinoma and its association with vasculogenic mimicry

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