A Review on Anticancer Potentials of Benzothiazole Derivatives

Abstract

: Benzothiazole is an organic compound bearing a heterocyclic nucleus (thiazole) which imparts a broad spectrum of biological activities to it. The significant and potent activity of benzothiazole moiety influenced distinctively by nature and position of substitutions. This review summarizes the effect of various substituents in recent trends and approaches to design and develop novel benzothiazole derivatives for anticancer potential in different cell lines by interpreting the Structure- Activity Relationship (SAR) and mechanism of action of a wide range of derivatives. The list of derivatives is categorized into different groups and reviewed for their anticancer activity. The structure-activity relationship for the various derivatives revealed an excellent understanding of benzothiazole moiety in the field of cancer therapy against different cancer cell line. Data obtained from the various articles showed the potential effect of benzothiazole moiety and its derivatives to produce the peculiar and significant lead compound. The important anticancer mechanisms found are tyrosine kinase inhibition, topoisomerase inhibition and induction of apoptosis by Reactive Oxygen Species (ROS) activation. Therefore, the design and development of novel benzothiazole have broad scope in cancer chemotherapy.

A Compendium of the Most Promising Synthesized Organic Compounds against Several Fusarium oxysporum Species: Synthesis, Antifungal Activity, and Perspectives

“…The inherent affinity of benzothiazole derivatives for diverse biological receptors makes them an ideal source for further developing lead candidates. This versatility has continually attracted academic attention, consequently disclosing a broad spectrum of bioactivities that benzothiazole analogs possess, such as analgesic, anticancer, anticonvulsant, antidiabetic, anti-inflammatory, antimicrobial, antimalarial, antiviral, and fungicidal [ 124 , 125 , 126 ]. Recently, Ballari et al, inspired by the properties of this privileged heterocyclic scaffold, reported in 2017 the synthesis of a series of 2-benzyl mercaptobenzoazoles through a green SN 2 methodology between the available 2-mercaptobenzothiazole and 2-mercaptobenzoxazole with different benzyl halides as starting materials [ 127 ].…”

Plantas Que Agem No Sistema Nervoso Central: O Uso Dos Fitoterápicos Kava Kava, Passiflora E Valeriana No Tratamento De Transtorno De Ansiedade

“…As cumarinas (2H-1-benzopiran-2-ona ou 2H-cromen-2-ona) são compostos de origem natural ou sintética do grupo fl avonóide que possuem atividade anticâncer, anti-HIV, antioxidante, antimicrobiana, entre outras bem descritas na literatura (ABDIZADEH et al, 2017 WU et al, 2009). (NATH et al, 2020;PATHAK et al, 2020). O desafio atual e as perspectivas futuras é aprimorar esses compostos para desenvolver novas moléculas com alta eficácia e menor efeitos adversos, trazendo benefícios terapêuticos para o paciente oncológico.…”

POTENCIAL DE USO DA Averrhoa carambola l. PARA DIABETES

“…Dentre os compostos heterocíclicos que estão atraindo a atenção da comunidade cientifica estão os Benzimidazois e os Benzotiazois. Diversos estudos científicos têm reportado o acentuado efeito citotóxico que esses compostos possuem contra células de câncer (NATH et al, 2020;PATHAK et al, 2020). O desafio atual e as perspectivas futuras é aprimorar esses compostos para desenvolver novas moléculas com alta eficácia e menor efeitos adversos, trazendo benefícios terapêuticos para o paciente oncológico.…”